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GI/Liver

Combination disease modifying antirheumatic drug (DMARD) therapy may not be only for rheumatoid arthritis; combining disease modifying agents may be the path to better renal response. Read more. https://t.co/0d1bxBlUS0 https://t.co/OZzJKwNJ4i
Dr. John Cush @RheumNow( View Tweet )
Jun 15, 2021
Video: Combination DMARD for Lupus Nephritis: Dr. Kathryn Dao ( @KDAO2011 ) #EULAR2021 https://t.co/RGVZ6jukYy https://t.co/PTjSOfM7YQ
Dr. John Cush @RheumNow( View Tweet )
Jun 09, 2021
#EULAR2021 POS0237: Gut dysbiosis linked to worse disease status in axSpA. ⭐️Dysbiosis in 33% of AxSpA vs 17% of controls wo rheumatic disease ⭐️Gut dysbiosis associated with worsening disease activity @RheumNow https://t.co/rRl4Zbs7xc
Eric Dein @ejdein1( View Tweet )
Jun 06, 2021
Gut dysbiosis linked to worse disease status in AxSpA ⭐️higher dysbiosis associated w/ worse EvalGlobal, ASDAS-CRP, BASDAI, BASFI, VAS pain ⭐️comparing dysbiosis vs. non-dysbiosis group - significant difference in BASDAI, BASFI, EvalGlobal Abs#POS0237 #EULAR2021 @RheumNow

Robert B Chao, MD @doctorRBC( View Tweet )

Jun 05, 2021
OP0010 at #EULAR2021. FLORA trial: Fecal microbiota transplant as add-on Rx to MTX. Small trial showing time-to-event curves show inferiority to sham but good safety. Fascinating concept exploring gut-joint interaction. @RheumNow. https://t.co/BIOmA5z6vK
Eric Dein @ejdein1( View Tweet )
Jun 02, 2021

RheumNow Podcast – Heart, Lung & Liver (5.28.2021)

May 27, 2021

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com.

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Virtual DDW meeting this wk reports claims data comparing IBD to IBD with RA - IBD alone vs IBD w/ RA dx w/ more depression (21% vs 84%), anxiety (20% vs 47%). IBD w/ RA had more depression (OR 7.2); anxiety (OR, 1.25;) or both (OR, 2.3) https://t.co/B78xcJw584

Dr. John Cush @RheumNow( View Tweet )

May 27, 2021

Tocilizumab Risk of Diverticulitis and GI Perforation

May 19, 2021

A French registry analysis compared the risk of diverticulitis and gastrointestinal perforation (GIP) in rheumatoid arthritis (RA) patients treated with biologics and found a greater risk of both in patients receiving tocilizumab (TCZ) compared with those on rituximab (RTX) or abatacept (ABA

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Checkpoint Inhibitor Safety in Melanoma Patients with Autoimmune Disease

May 18, 2021

Immune checkpoint inhibitors (ICI) are well known to cause immune-related adverse events (irAEs). A study from the Dutch Melanoma Treatment Registry shows that the use of checkpoint inhibitors for advanced melanoma in AID (autoimmune disease) patients did not increase the risk of irAEs, except

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Increased Methotrexate Liver Disease in Psoriasis https://t.co/sEZajDIkSz

Dr. John Cush @RheumNow( View Tweet )

May 16, 2021

RheumNow Live 2021 Now Available for All

May 14, 2021

RheumNow Live (RNL) for 2021 was held March 20 - 21 in Fort Worth, TX, and now all can partake in the meeting - by video, podcast or by signing up for Tuesday Nite Rheumatology (TNR).



RNL has finished its 3rd year as a hybrid meeting, with the live meeting streamed to hundreds at home

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Drug Monitoring Ineffective with Infliximab Treatment

May 05, 2021

The predictive value of therapeutic drug monitoring (TDM) while on biologics is debateable; gastroenterology routinely relies on TDM, while rheumatologists do not. A randomized trial compared TDM to no TDM in patients receiving infliximab for chronic immune-mediated inflammatory diseases (

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Results Disappoint for Fecal Transplant in Arthritis

MedPage Today
May 04, 2021

Fecal microbiota transplantation (FMT) showed disappointing results among patients with active psoriatic arthritis, a small randomized trial found.



During 26 weeks of follow-up, the risk of treatment failure was higher among patients receiving FMT compared with those given a sham

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RheumNow Podcast – Coconspirators: RA and Lung Disease

Apr 23, 2021

Dr. Jack Cush reviews and discusses more than a dozen news and journal articles from the past week on RheumNow.com.

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Increased Methotrexate Liver Disease in Psoriasis

Apr 22, 2021

A Danish cohort study examined the risk of methotrexate related liver disease risk in patients with psoriasis (PsO)and psoriatic arthritis (PsA), and found that compared to rheumatoid arthritis (RA), psoriatic patients had up to a 3 fold higher risk of liver disease. 



In a population-

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RheumNow Podcast – Combination Biologics

Apr 16, 2021

Dr. Jack Cush serves up this week's news and articles from RheumNow.com.

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Metanalysis of IBD studies finds combo biologics may have efficacy in refractor IBD. 279 IBD pts Rx w/ dual biologic or JAKi Rx . Most common = TNFi + anti-integrins (48%), ustekinumab & integrins (19%); remission seen in 59% & 34%, higher w/ EIM https://t.co/RReyRuNXck

Dr. John Cush @RheumNow( View Tweet )

Apr 13, 2021

Reactogenicity Following mRNA COVID-19 Vaccines

Apr 06, 2021

JAMA has published the real-world reporting of mRNA vaccine side effects (reactogenicity) gathered from CDC V-safe Surveillance system and shows that local and systemic reactions were often mild and transient and most commonly seen during the first day following their second dose.

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RheumNow Podcast – Upadacitinib Wins in PsA (4.2.2021)

Apr 02, 2021

Dr Jack Cush reviews the news and Journal reports and takes "Back Talk" questions from viewers.

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Liver Management in RA - #RNL2021 Highlight by @DrPetryna While RA is not known to affect the liver directly, underlying liver disease and treatment-related effects on the liver can often become an obstacle in the mgmt of many RA patients. https://t.co/OeuloDIXMF

Dr. John Cush @RheumNow( View Tweet )

Mar 27, 2021
News Feature: Liver Management in Rheumatoid Arthritis - #RNL2021 Highlight by Dr. Olga Petryna ( @DrPetryna ) https://t.co/OeuloE0yEd https://t.co/qYd1K0dADu
Dr. John Cush @RheumNow( View Tweet )
Mar 23, 2021

Safety of Paternal DMARD or Biologic Use

Mar 22, 2021

A large cohort study of expectant fathers treated for immune-mediated inflammatory diseases (IMIDs) failed to show any detrimental effect from paternal exposure to immunosuppressive or biologic agents on offspring outcomes.

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Liver Management in Rheumatoid Arthritis - RNL2021 Highlight

Mar 22, 2021

While rheumatoid arthritis (RA) is not known to affect the liver directly, underlying liver disease and treatment-related effects on the liver can often become an obstacle in the management of many RA patients. In his Sunday presentation at RNL2021, Dr. Stanley Cohen detailed many issues

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News Feature: Low IBD Risk with IL-17 Inhibition https://t.co/1kUH7sP755 https://t.co/DypPAcxB2a
Dr. John Cush @RheumNow( View Tweet )
Mar 09, 2021

Low IBD Risk with IL-17 Inhibition

Mar 08, 2021

Incident or worsening colitis is a rare complication of IL-17 inhibitor therapy; a real world study confirms very low rates of new IBD in patients starting secukinumab.



A real-world study of the secukinumab (SEC; an IL-17 inhibitor) and gastrointestinal related adverse events (GIRAE)

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