Skip to main content

GI/Liver

Best Rheumatologists (7.19.2024)

This week on the RheumNow Podcast, Dr. Jack Cush reviews the news and journal reports of interesting, including irAE, pollution and Psoriasis, microwave therapy, scleroderma without scleroderma that only the best rheumatologists could discern.

Read Article
Pathogenesis of Autoimmune Liver Disease (ALDs) ALDs, including autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC), are complex conditions involving the liver's immune-mediated damage https://t.co/acgwwglKve https://t.co/ZDpF1VhBlc
Dr. John Cush @RheumNow( View Tweet )

Systemic sclerosis sine scleroderma

Systemic sclerosis sine scleroderma (ssSSc), which accounts for nearly 10% of systemic sclerosis (SSc) patients and was first described in 1962, is a subset of SSc.

Read Article
Review of Amyloidosis The New England Journal of Medicine has published a review of systemic amyloidosis. https://t.co/4507N4DwLk https://t.co/Q0MP5XXUHr
Dr. John Cush @RheumNow( View Tweet )
FDA has approved risankizumab (Skyrizi) to treat adults with moderately to severely active ulcerative colitis (UC), making it the IL-23 inhibitor approved for UC. Approval is based on two large phase 3 clinical trials (COMMAND, INSPIRE) https://t.co/wNSZdWWDO1 https://t.co/mlwxIrdUD2
Dr. John Cush @RheumNow( View Tweet )

New indications for JAK inhibitors

There are several new positive RCTs for JAK inhibitors. Here is a summary of trials and new indications for JAKi in GCA, pediatrics, GI, dermatology and more.

Read Article

Inflammatory bowel disease in spondyloarthritis - does it matter?

Do the clinical features of axSpA patients with and without IBD differ?

In Abstract OP0085 at #EULAR2024, De Hooge M et al presented data from the METEOR cohort that identify clinical differences between these two groups. This will be important in order to stratify the management approach

Read Article
SpA patients with IBD, compared to those without IBD, were less frequently male and more frequently HLA-B27 negative, had higher rates of uveitis and lower rates of psoriasis, exhibited more structural damage on SI joints in the METEOR cohort #EULAR2024 OP0085 @RheumNow https://t.co/c2KdzIumc4
Dr. Antoni Chan @synovialjoints( View Tweet )
Research presented at DDW 2024 demonstrated the superiority of guselkumab over ustekinumab or placebo in 1,021 patients with moderately to severely active Crohn's disease enrolled in the phase III GALAXI 2 and GALAXI 3 trials https://t.co/HdZf24Twsq https://t.co/REeAAskpX5
Dr. John Cush @RheumNow( View Tweet )

"Don't You Know Who I am?" (5.17.2024)

Dr. Jack Cush reviews the news and journal reports from the past 2 weeks. This week's question: can we prevent gout, ILD or psoriasis?

Read Article
Cohort study 243 671total joint arthroplasty pts finds found no association of preoperative or postoperative colonoscopy with Periop Jt Infx risk w/ 1-yr F/U. PJI risk was incr by comorbidity (diabetes, kidney disease, and pulmonary disease). https://t.co/0J8F9YN2l2 https://t.co/USoplPPHh3
Dr. John Cush @RheumNow( View Tweet )

Featured BSR Abstracts (5.2.2024)

Dr. Jack Cush muses on the news, journal reports, FDA announcements and the 2024 BSR abstracts just released.

Read Article

Ides of March (3.15.2024)

Dr. Jack Cush has advice for Caesar and the superstitious, and covers pregnancy, platelets, dialysis and vaccinations in Lupus.





  1. Dutch study of 586 RA pts on bDMARDs found more nonserious infections (NSIE) (77/100PYs) than serious infx (SIE)(1.3/100Pys). Upper respiratory

Read Article
Endoscopy and Worry are indicated in the face of DYSPEPSIA and any of these: @BCryer https://t.co/6TabKhiLPO
Dr. John Cush @RheumNow( View Tweet )
Testing for H. Pylori. Serologic tests are OK but after Rx eradication, 25% of pts will remain positive for H. Pylori. @BCryer

Dr. John Cush @RheumNow( View Tweet )

Multiple Rx options to treat H. Pylori - Dr. Cryer recs regimens of 14ds; top line w/ bismuth is most recommended. (most effective is the one the patient will actualy take!) @BCryer https://t.co/f6836Ga1Fz
Dr. John Cush @RheumNow( View Tweet )
H. Pylori is usually acquired during childhood, remains dormant until activated years later. Is assoc w/ PUD and gastric cancer, not dyspepsia. Baylor Univ Grand Round By Dr. Byron Cryer @BCryer https://t.co/KXZfigVYX9
Dr. John Cush @RheumNow( View Tweet )
Is non-alcoholic fatty liver dz assoc w/ osteoarthritis? Study of 2633 pts - 317 (12.8%) w/ OA& 1140 NAFLD(41.5%); NAFLD was positively correlated with OA (OR = 1.72; 1.26–2.34). https://t.co/whWX2XIu3d https://t.co/sGXQYSFcH3
Dr. John Cush @RheumNow( View Tweet )
You are what you eat! So how does the Mediterranean diet affect the gut? *maintaining/shaping healthy gut microbiota *enhancing anti-inflammatory metabolite production *maintaining intestinal barrier integrity Dr. M. Guma #RNL2024 @RheumNow https://t.co/O9by7CahRW
Dr. Rachel Tate @uptoTate( View Tweet )
How does the Mediterranean diet affect inflammation? Dr. Guma noted the diet helps to: 1. maintain healthy microbiota 2. enhance production of anti-inflammatory metabolites 3. maintain intestinal barrier integrity. #RNL2024 @rheumnow https://t.co/d3ByStvXyR
TheDaoIndex @KDAO2011( View Tweet )
Dr. M Guma noted @ACRheum 2022 Guidelines on RA recommend the #MediterraneanDiet; studies have shown this diet reduces CV risk, RA disease activity #RNL2024 @RheumNow https://t.co/AdKWgME4nD
TheDaoIndex @KDAO2011( View Tweet )

2023 Rheumatology Year in Review

Dr. Jack Cush reviews highlights, advances and hot topics in rheumatology from 2023 and the RheumNow website.  



2023 was a year of growth and new horizons while returning to operational and practice standards (in care and education) established before the pandemic.  

Read Article

Best of 2023: LAVLI - A New Autoinflammatory Disorder

NIH researchers have have described a novel autoinflammatory disorder called "Lyn kinase-associated vasculopathy and liver fibrosis" (LAVLI), based on a mutation in the LYN gene (that encodes the Lyn kinase protein). They discovered that increased Lyn kinase activity promotes

Read Article

ICYMI: SpA Sleuths: The Case of Undiagnosed IBD

Abstract #0494 provides context to our continual search for better understanding of inflammatory bowel disease in patients with AS, nr-AxSpA, and PsA.

Read Article

ICYMI: Do Probiotics Improve Psoriatic Arthritis?

Psoriatic arthritis and the gut microbiome have become more intertwined, especially in the past few years. It was to my amazement that one of the first abstracts I came across was the effect of probiotic modulation on gut dysbiosis and disease activity in psoriatic arthritis patients. 

Read Article