GI/Liver

Danish matched (1:4) cohort study shows COVID-19 pts taking NSAIDs had no greater risk of mortality, hospitalization, ICU admission, mechanical ventilation, or renal replacement therapy; study included 9,236 COVID PCR-positive & 2.7% were on NSAIDs https://t.co/

Links:

https://bit.ly/3caMNPP

Dr. John Cush RheumNow ( View Tweet)

Sep 15, 2020

Comorbidities Impact Disease Activity in Spondyloarthritis

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Jack Cush, MD

Sep 13, 2020

An analysis of a large population-based cohort of axial spondyloarthritis (axSpA) patients shows that comorbidities are common and are associated with higher disease activity and higher levels of functional impairment.

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Dr Uma Mahadevan and colleagues have published guidelines for managing pregnancy in IBD patients. Rec coordinated care w/ maternal-fetal medicine subspecialist, GI doc, preconception planning, more on treatement https://t.co/oAFcGlOU2y

Links:

https://bit.ly/3jYzggE

Dr. John Cush RheumNow ( View Tweet)

Sep 10, 2020

Treatment Options for Extraintestinal IBD

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Jack Cush, MD

Sep 03, 2020

Extraintestinal manifestations (EIMs) frequently accompany inflammatory bowel disease, often augmenting morbidity and mortality are associated with disease activity and may increase the need for surgery or treatment escalation. A recent review in GUT details the treatment options for patients

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Comparative retrospective study of 251 ANCA+ pts with AAV (MPA or GPA) & severe renal Dz induction Rx with CYC or RTX, +/- PLEX. Remission equally achieved by CTX or RTX; addition of PLEX did not change outcomes.

Links:

https://bit.ly/2Gh40uX

Dr. John Cush RheumNow ( View Tweet)

Sep 01, 2020

UK safety reminder that Baricitinib (Olumiant) has an increased risk of diverticulitis (incidence rate 0.16 per 100PY), esp. in those taking Steroids or NSAIDs. https://t.co/IfcV03e1p7

Links:

https://bit.ly/3gCfV2R

Dr. John Cush RheumNow ( View Tweet)

Aug 28, 2020

Hepatitis C Anti-Viral Drug-Induced Arthritis

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Jack Cush, MD

Aug 27, 2020

Curative direct-acting antiviral therapy (DAAT) for hepatitis-C virus (HCV) infection has been revolutionary, but a novel report shows that nearly one quarter of DAAT treated patients developed new onset or significant worsening of MSK symptoms, despite being negative for hepatitis-C by PCR

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RheumNow Podcast - The Bad News That's Fit to Print (8.21.20) Dr Jack Cush reviews this week highlights filgotinib rejection, delays in Diagnosis, metformin benefits COVID, Abx and IBD, and UPA beats MTX https://t.co/1oZtU14VOB

Links:

https://bit.ly/2QbmS0b

Dr. John Cush RheumNow ( View Tweet)

Aug 22, 2020

RheumNow Podcast – The Bad News That’s Fit to Print (8.21.20)

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Jack Cush, MD

Aug 20, 2020

Dr Jack Cush reviews the news and journal reports from the past week on RheumNow: filgotinib rejection, delays in diagnosis, metformin benefits COVID, Abx and IBD, and UPA beats MTX.

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Antibiotic use is associated with a higher rate of IBD (aOR 1.88; 1·79–1·98) based on a prospective case-control study from the Karolinska that compared 23,982 new IBD pts w/ 117,827 matched controls followed over 10 years. https://t.co/FbCVU5GEFo

Links:

https://bit.ly/3h6AqWv

Dr. John Cush RheumNow ( View Tweet)

Aug 19, 2020

BMS has announced deucravacitinib: the generic name for its Tyk2 inhibitor (BMS-986165) - 15 long makes it a new rheum labeling record. It's being studied in Psoriatic arthritis, psoriasis, lupus and inflammatory bowel disease. https://t.co/E2x2lelktO

Links:

https://bit.ly/33ETcjQ

Dr. John Cush RheumNow ( View Tweet)

Aug 07, 2020

Hong Kong study Myositis-specific autoantibodies in 201 pts with idiopathic inflammatory myopathies (IIM) shows MDA-5 (14%), TIFF-1γ (14%), Jo-(12.4%). MDA5 seen w/ DM, digital ulcers, amyopathy, ILD.

Links:

https://bit.ly/2PtU9TU

Dr. John Cush RheumNow ( View Tweet)

Aug 07, 2020

GI Perforations with Tocilizumab Greater than Other Biologics

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Jack Cush, MD

Jul 27, 2020

A study from a Swedish population shows the real-world risk of gastrointestinal (GI) perforations in rheumatoid arthritis (RA) patients taking biologics finds that the risk was greatest in RA patients taking tocilizumab (TCZ), compared with RA patient taking tumour necrosis factor inhibitors (

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The RheumNow Podcast is up - COVID-19 Responds to Steroids & TCZ, statin myopathy, Lung Dz in AOSD, TNFi & Liver, IL-23 in Psoriasis.

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Dr. John Cush RheumNow ( View Tweet)

Jul 24, 2020

RheumNow Podcast – COVID-19 Responds to Steroids (7.24.20)

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Jack Cush, MD

Jul 24, 2020

Dr. Jack Cush reviews the News and Journal Reports from the past week on RheumNow.com.

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Metanalysis of 7 RCTs looked at melanoma risk comparing 34 029 biologic Tx vs 135 370 non-biologic conventional systemic Tx pts, showing no signif.

Links:

https://bit.ly/32M4C50

Dr. John Cush RheumNow ( View Tweet)

Jul 23, 2020

Literature review suggests that TNF inhibitors are safe to use in NAFLD and may show a beneficial effect on hepatic tissue. TNFi should be prescribed with caution in patients w/ cirrhosis as the data are conflicting. https://t.co/uynkNNCxdt

Links:

https://bit.ly/2Cn6pCN

Dr. John Cush RheumNow ( View Tweet)

Jul 22, 2020

Retrospective cohort of 147 Adult-Onset Stills Dz pts finds 18 (12.3%) with lung dz (LD) at the diagnosis of AOSD. AOSD-LD were older, w/ more myalgia, LN, pleuritis, ab,dominal pain, more systemic Dz, higher ferritin and more mortality (%39 vs 10%).

Links:

https://bit.ly/2E0BQmF

Dr. John Cush RheumNow ( View Tweet)

Jul 22, 2020

45 yr adult male w/ Kawasaki-like multisystem inflammatory syndrome w/ COVID-19 infx: presented w/ 6d fever, sore throat, diarrhea, LN, BLE pain, conjunctivitis, tachycardia, ESR 120, CRP 546 mg/L, high Troponin; Rx and resolved w/ IVIG & TCZ https://t.co/cy

Links:

https://bit.ly/2CuKB8d

Dr. John Cush RheumNow ( View Tweet)

Jul 21, 2020

FDA has approved a 6th adalimumab biosimilar - called Hulio (adalimumab-fkjp) with indications of rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, adult Crohn’s disease, ulcerative colitis, psoriasis.

Links:

https://bit.ly/3h0SYqN

Dr. John Cush RheumNow ( View Tweet)

Jul 13, 2020

Extrapulmonary Manifestations of COVID-19

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Jack Cush, MD

Jul 13, 2020

A new article in Nature Medicine delineates how our understanding of COVID-19 infection has evolved over time, such that the infection outomes may be worsened by extrapulmonary manifestations; notably thrombotic, cardiac, renal, gastrointestinal hepatic, neurologic, and other complications.

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PRES - Posterior reversible encephalopathy syndrome. Review of US hosp records finds 3125 cases.

Links:

https://bit.ly/2VC4PTR

Dr. John Cush RheumNow ( View Tweet)

Jul 02, 2020

Liver.hepatitis.jpg

Liver Abnormalities in Psoriatic Arthritis

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Jack Cush, MD

Jul 01, 2020

A new report in the Journal of Rheumatology shows that liver abnormalities are common in psoriatic arthritis (PsA) and may be associated with obesity, more severe disease and select therapies.

An analysis of a prospective PsA cohort study included 1061 patients. Of these, over one-

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Rituximab (RTX)-associated autoimmune disease flare is rare and only seen in 7/185 pts (3.4%); all w/ type II mixed cryoglobulinemia vasculitis.

Links:

https://bit.ly/3eTOh16

Dr. John Cush RheumNow ( View Tweet)

Jul 01, 2020

If you treat #SLE patients, Do you get a renal biopsy before starting therapy for Lupus nephritis?

Dr. John Cush RheumNow ( View Tweet)

Jun 27, 2020

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