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GI/Liver

Reactogenicity Following mRNA COVID-19 Vaccines

Apr 06, 2021

JAMA has published the real-world reporting of mRNA vaccine side effects (reactogenicity) gathered from CDC V-safe Surveillance system and shows that local and systemic reactions were often mild and transient and most commonly seen during the first day following their second dose.

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RheumNow Podcast – Upadacitinib Wins in PsA (4.2.2021)

Apr 02, 2021

Dr Jack Cush reviews the news and Journal reports and takes "Back Talk" questions from viewers.

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Liver Management in RA - #RNL2021 Highlight by @DrPetryna While RA is not known to affect the liver directly, underlying liver disease and treatment-related effects on the liver can often become an obstacle in the mgmt of many RA patients. https://t.co/OeuloDIXMF

Dr. John Cush @RheumNow( View Tweet )

Mar 27, 2021
News Feature: Liver Management in Rheumatoid Arthritis - #RNL2021 Highlight by Dr. Olga Petryna ( @DrPetryna ) https://t.co/OeuloE0yEd https://t.co/qYd1K0dADu
Dr. John Cush @RheumNow( View Tweet )
Mar 23, 2021

Safety of Paternal DMARD or Biologic Use

Mar 22, 2021

A large cohort study of expectant fathers treated for immune-mediated inflammatory diseases (IMIDs) failed to show any detrimental effect from paternal exposure to immunosuppressive or biologic agents on offspring outcomes.

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Liver Management in Rheumatoid Arthritis - RNL2021 Highlight

Mar 22, 2021

While rheumatoid arthritis (RA) is not known to affect the liver directly, underlying liver disease and treatment-related effects on the liver can often become an obstacle in the management of many RA patients. In his Sunday presentation at RNL2021, Dr. Stanley Cohen detailed many issues

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News Feature: Low IBD Risk with IL-17 Inhibition https://t.co/1kUH7sP755 https://t.co/DypPAcxB2a
Dr. John Cush @RheumNow( View Tweet )
Mar 09, 2021

Low IBD Risk with IL-17 Inhibition

Mar 08, 2021

Incident or worsening colitis is a rare complication of IL-17 inhibitor therapy; a real world study confirms very low rates of new IBD in patients starting secukinumab.



A real-world study of the secukinumab (SEC; an IL-17 inhibitor) and gastrointestinal related adverse events (GIRAE)

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Italian IBD clinic with 90 IBD Vedolizumab Tx pts, 8%(11) developed severe enthesitis (4 Multifocal, 6 unifocal). Sxs after mean 46 wks, CRP=5.1 mg/dl, majority HLA-B27 negative; confirmed by PD/UA in 7 - 4/7 developed post-inflam entheseal calcifications https://t.co/uwAJM8giBX

Dr. John Cush @RheumNow( View Tweet )

Feb 17, 2021

Checkpoint Inhibitor Use with Pre-existing Autoimmune Disease

Feb 17, 2021

Annals of Internal Medicine reports treating advanced melanoma with immune checkpoint inhibitors (ICI) in patients with pre-existing autoimmune disease (AID) was as effective and safe in those with AID compared to those without AID, although severe colitis occurred more frequently among

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Dr Uma Mahadevan presents results of the 14 yr registry study of pregnancy in IBD (Crohn's &UC) 1431 pts on with no Rx, thiopurines, biologics or thiop+biologics, showed no rush of fetal malformation, but did have incr in spont abortions @RWCSmtg @UmaMahadevanIBD https://t.co/SVQ2q1mJNW
Dr. John Cush @RheumNow( View Tweet )
Feb 13, 2021
Cardiac and Cancer Signals Tofacitinib Safety Alert from FDA The FDA has notified healthcare professionals of a safety alert concerning tofacitinib (Xeljanz) when given to at-risk rheumatoid arthritis patients. https://t.co/RJD8CMouHK https://t.co/bipwWlIhiB
Dr. John Cush @RheumNow( View Tweet )
Feb 05, 2021
Metanalysis of 3 cross-sectional & 2case-control studies shows that the risk of developing #RA is elevated in patients with Crohns colitis (RR = 3.14; 95% CI: 2.46–4.01) and ulcerative colitis (RR = 2.29; 95% CI: 1.76–2.97) https://t.co/TIpd6lh5IZ

Dr. John Cush @RheumNow( View Tweet )

Feb 04, 2021
QD Clinic - When RA Meets UC Ulcerative Colitis is complicating RA therapy https://t.co/a0LPvqPe1t

Dr. John Cush @RheumNow( View Tweet )

Feb 03, 2021
QD Clinic - Arthritis and Colitis https://t.co/U5NrQuIcrd https://t.co/LbuRy9pTIl
Dr. John Cush @RheumNow( View Tweet )
Jan 27, 2021
Ehlers-Danlos Syndrome pts have higher association with GI conditions (IBS, etc OR =3.57), POTS & Autonomic dysfunction (OR=4.4), food allergy (OR= 3.9), CV complications (OR 6.1; MV dx, aortic aneurysm), longer hospitalizations (OR= 1.76) https://t.co/noobvrx0cQ

Dr. John Cush @RheumNow( View Tweet )

Jan 21, 2021
UTSW Rheum Grand Rounds - IgG4 Dz commonly presents as major salivary and lacrimal gland enlargement, orbital disease, autoimmune pancreatitis, retroperitoneal (mass) fibrosis or tubulointerstitial nephritis. @UTSWIMchief

Dr. John Cush @RheumNow( View Tweet )

Jan 21, 2021

Corticosteroid Use Hikes CV Risks in Rheumatic Patients

Jan 11, 2021

UK Clinical Practice Research Datalink population study shows that patients with immune-mediated inflammatory diseases, such as RA, PMR, GCA and IBD, have an augmented risk of CV outcomes with glucocorticoid use; even lower doses had a near doubling of their underlying CVD risk.

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#BestACR20Tweets RT @doctorRBC : AxSpa pts had Significant Gut Microbiome Differences in: 1⃣Disease activity and duration 2⃣Enthesitis 3⃣Radiographic involvement Abs#1853 https://t.co/ynemrgsP3W
Dr. John Cush @RheumNow( View Tweet )
Dec 07, 2020

PIANO Study - Safety of Biologics in Pregnancy

Dec 03, 2020

The results of the long awaited PIANO study have been reported in the journal Gastroenterology, showing that pregnant women with IBD may safely receive biologic or thiopurine therapy throughout the pregnancy without substantial added risk to the unborn or mother.

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Hypophosphatasia - CPPD/chondrocal, enthesop'y, DISH, exostoses - DDx of Low ALP: milk-alkali, Vit D intoxic'n, Wilson dz, via C def, celiac dz, adyn renal osteodystrophy, Cushing dz, hypothyroid, major sx, MM Rx - asfotase alpha- bone targeted replac't Rx #ACR20 #ACRambassador https://t.co/FJ1355MdKG
Vaneet K Sandhu, MD @vksandhumd( View Tweet )
Nov 10, 2020
In patients with Crohn's disease (CD), the presence of HLA-B27 and higher clinical activity of CD were associated with presence of SpA. SpA was present in 21% of early CD patients @RheumNow #ACR20 Abstr#1308

Dr. Antoni Chan @synovialjoints( View Tweet )

Nov 08, 2020
Minimum Clinically Important Improvement in Patients with Rheumatoid Arthritis Associates with Gut Microbiome https://t.co/D3ILR57gXY #RA #microbiome that microbiome again

Peter Nash @drpnash( View Tweet )

Nov 07, 2020
Liver damage is NOT an extra-articular manifestation of RA BUT the ff'g factors are associated with liver disease in RA & can complicate management👇@RheumNow #ACR20 https://t.co/RqL69iVJpC
Nov 07, 2020

RheumNow Podcast – ACR 20 is Coming to Town (10.30.20)

Oct 29, 2020

Dr Jack Cush overviews the RheumNow commitment, upcoming bonus coverage of ACR20 and the good news and journal reports from the past week on RheumNow.com

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