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Pharma/Regulatory

Pain Persists in RA, Even Without Inflammation

MedPage Today
Jun 23, 2021

One-third of patients with rheumatoid arthritis had unacceptably high levels of pain 5 years after diagnosis, often despite low levels of inflammation, Swedish researchers found.



In an inception cohort of 232 patients with early rheumatoid arthritis, 34.1% still reported unacceptable

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Better Outcomes with Modern T2T in Pregnancy

Jun 23, 2021

With the expansion of knowledge regarding the safety of newer agents in pregnancy comes the PreCARA study showing that when pregnancy is planned and patients with rheumatoid arthritis (RA) are treated with a modified treat-to-target (T2T) approach, superior outcomes can be anticipated.

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Progression from Psoriasis to Psoriatic Arthritis

Jun 22, 2021

The question of whether psoriasis is a state or pre-clinical psoriatic arthritis has been addressed by several studies; with one suggesting that biologic use in psoriasis may aver the future development of psoratic arthritis (PsA).



A retrospecitve analysis of non-randomized moderate-

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FINCH 1 Trial Filgotinib in Rheumatoid Arthritis

Jun 22, 2021

The Annals of Rheumatic Disease has published the results of a head-to-head trial showing that the Janus kinase-1 (JAK1) preferential inhibitor filgotinib was superior to a tumour necrosis factor-α inhibitor (adalimumab) in active rheumatoid arthritis (RA) on methotrexate (MTX).

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Treatment of MIS-C COVID in Kids

Jun 21, 2021

The NEJM has published results of a real-world efficacty trial showing that COVID infected children with the multisystem inflammatory syndrome in children (MIS-C) respond better to initial IVIG plus glucocorticoids (than IVIG alone) which was associated with less subsequent cardiovascular

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Problems at the FDA https://t.co/mkCrYAVudo https://t.co/fAE1pNSg0q
Dr. John Cush @RheumNow( View Tweet )
Jun 21, 2021

Tofacitinib Efficacy in COVID-19 Pneumonia

Jun 21, 2021

NEJM has published the results of an observational trial wherein tofacitinib given to patients hospitalized with Covid-19 pneumonia, was shown to significantly lower risk of death or respiratory failure.



This multicenter trial was conducted in Brazil. A total of 289 hospitalized

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EULAR 2021 – Day 4 Report

Jun 17, 2021

It's been nearly two weeks since EULAR 21 ended. There were several presentations on the last day; notably, the late breaking abstracts and others. Here are a few of my favorites from Day 4, the final day of the meeting.

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Problems at the FDA

Jun 16, 2021

"While the Food and Drug Administration decision on new drugs usually follows the recommendations of the advisory committee..."; this oft used proviso is used to either indicate a pending FDA decision or an FDA decision that is contrary to the recommendation of the advisory committee convened

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RheumNow Podcast - Best of EULAR 2021

Jun 11, 2021

Dr. Jack Cush reviews and highlights his favorite abstracts and presentations from last week's virtual EULAR 2021 meeting.

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Novel TYK2 Inhibitor Efficacious for Treatment of Psoriatic Arthritis

Dr. Philip Mease et al presented results of a phase II trial (OP0227) at EULAR 2021 that shows the efficacy and safety of an oral tyrosine kinase inhibitor (TYKi), deucravacitinib, for treatment of active psoriatic arthritis (PsA).

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#EULAR2021 and EULAR IQ Dr Jack Cush reviews highlight presentations from the first 3 days of EULAR 2021. https://t.co/BkHjhOUqNU https://t.co/4JS1yGiJHg
Dr. John Cush @RheumNow( View Tweet )
Jun 05, 2021

EULAR 2021 - Day 2 Podcasts

Jun 04, 2021

Check out this compilation of our EULAR 2021 Day 2 broadcasts below.



You can also follow the EULAR 2021 RheumNow podcasts on iTunes and Soundcloud.com



Listen by Clicking below:



1. EULAR2021 - Day2a



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RheumNow Podcast - EULAR 2021 & EULAR-IQ (6.4.21)

Jun 04, 2021

Dr Jack Cush reviews highlight presentations from the first 3 days of EULAR 2021.


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Foot Pain Commonly Overlooked in RA

MedPage Today
Jun 01, 2021

Foot pain is a common but underappreciated symptom of rheumatoid arthritis (RA) and can be associated with worse disease, European researchers found.



In a cohort of 320 patients with RA, 69% reported foot or ankle pain, according to Morten Bilde Simonsen, PhD, of Aalborg University in

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Best Interventions for Gout Flares

May 31, 2021

A recent metanalysis assessed the comparative efficacy of current first-line pharmacologic antiinflammatory interventions for gout flares and surmised that canakinumab and intravenous or intramuscular corticosteroids are superior to  nonsteroidal antiinflammatory drugs [NSAIDs].



From

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RheumNow Podcast – Heart, Lung & Liver (5.28.2021)

May 27, 2021

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com.

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Methotrexate Impairs COVID Vax Response

MedPage Today
May 27, 2021

One-third of patients with immune-mediated inflammatory diseases being treated with methotrexate showed attenuated responses to the COVID-19 vaccine, researchers reported.



In two independent cohorts, robust antibody responses were observed in 98.1% of healthy controls and in 91.9% of

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Triple DMARD Therapy Bested by Biologics in Swedish Registry

May 26, 2021

The Swedish Register compared outcomes of 1502 rheumatoid arthritis (RA) patients initiating either biologics plus methotrexate (MTX) or triple therapy (MTX plus sulfasalazine plus hydroxychloroquine/chloroquine) and showed similar rates of sustained remission.



Sustained remission was

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CV Risk Decreased with Certain DMARDs in Rheumatoid Arthritis

May 25, 2021

A large prospective cohort study examined the comparative risks of cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA) and found that, methotrexate (MTX), abatacept (ABA) and TNF inhibitor (TNFi) use were associated with a decreased risk of CV events. 

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Tocilizumab Augmented Efficacy in COVID-19 Pneumonia with High CRP

May 25, 2021

JAMA Internal Medicine report an analysis of recent and composite trial data suggesting that tocilizumab (TCZ) therapy in COVID-19–associated pneumonia patients with high CRP levels is likely to be effective.

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Congress Slams AbbVie Over Price Hikes, 'Frivolous' Patents

MedPage Today
May 24, 2021

House lawmakers on both sides of the aisle pummeled AbbVie CEO Richard Gonzalez for raising the price of two widely used drugs and for the company's "legally questionable" tactics to head off competition from biosimilars, despite pulling in healthy profits.



Much of Tuesday's House

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Factors Associated with COVID-19 Deaths in Rheumatic Patients

May 24, 2021

Analysis of data from the COVID-19 Global Rheumatology Alliance shows that rheumatic diseases infected with COVID-19 had a greater risk of death with age, comorbidities, high disease activity and few specific therapies.



Rheumatic disease adults with a confirmed or presumptive COVID-19

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RheumNow Podcast – Myth Busters (5.21.2021)

May 21, 2021

Dr Jack Cush reviews the news and journal reports from the past week on RheumNow.com




  1. Metanalysis (11 RCTs, 19 registries) of Pulm arterial HTN assoc. w/ CTD (w/ 1,267 & 4,008 CTD-PAH pts), showed Investigational Rxs reduced morbidity/mortality by 36%. CTD-PAH survival

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Lower Rates of Serious Infection with Ustekinumab in Psoriatic Disease

MedPage Today
May 20, 2021

Patients with psoriasis or psoriatic arthritis who were being treated with ustekinumab (Stelara) had lower rates of serious hospitalized infections than patients receiving other biologics or small molecule therapies, a study utilizing data from two commercial claims databases found.

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