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Sjogrens

Do B-cell targeted therapies still have a place for the treatment of Sjogren’s?

B-cells play a major role in the pathogenesis of primary Sjogren’s syndrome (pSS) through antibody-dependent and antibody-independent functions, as well as evident by progression to B-cell malignancies/lymphoma. Hence, targeting B-cell is attractive. Despite efficacy of B-cell depleting therapy

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Do B-cell targeted therapies still have a place for the treatment of Sjogren’s? https://t.co/96sv3beMvG https://t.co/oabgmkAfGk
Dr. John Cush @RheumNow( View Tweet )
Jun 13, 2021
Can the Focus Score predict Lymphoma in Sjogren’s syndrome? by Dr. Eric Dein ( @ejdein1 ) https://t.co/B5HN6ju3ru https://t.co/3MuXH66YqJ
Dr. John Cush @RheumNow( View Tweet )
Jun 09, 2021

Can the Focus Score predict Lymphoma in Sjogren’s syndrome?

Jun 08, 2021

Patients with Sjogren’s syndrome are nearly 19 times more likely to develop lymphoma, so identifying factors that impact this risk development is a major goal in caring for this disorder. Many risk factors are established such as low C4, palpable purpura, parotid gland enlargement, and

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Do B-cell targeted therapies still have a place for the treatment of Sjogren’s? #EULAR2021 https://t.co/96sv3beMvG https://t.co/EWKCA1KGsC
Dr. John Cush @RheumNow( View Tweet )
Jun 08, 2021
#EULAR2021 POS0230: TNFi changes intestinal microbiota in IBD-SpA ⬇️ Proteobacteria ⬆️Lachnospiraceae, Coprococcus Does inflammatory changes by TNFi restore intestinal eubiosis and does this affect SpA outcomes? @Rheumnow

Eric Dein @ejdein1( View Tweet )

Jun 05, 2021
Talk about unmet need. We must get better Rx for #Sogren’s Syndrome! Large survey show quality of life v poor in SS & correlates with degree of dryness in lacrimal & salivary glands POS0102 #EULAR2021 @eular_org @RheumNow

Janet Pope @Janetbirdope( View Tweet )

Jun 04, 2021
If we want drugs to be effective in #Sjogren’s Syndrome we need to see activity. The #Eular SS disease activity index ~ESSDAI in 511 SS pts found >50% w moderate to severe values BUT how much is Reversible ie fibro, fatigue, scarred glands? POS0105 @RheumNow @eular_org #EULAR2021

Janet Pope @Janetbirdope( View Tweet )

Jun 04, 2021
Does anti-CD20 mAb still have a place in #Sjogren? Dr Pontarini analysed salivary gland biopsy from TRACTISS and reported beneficial effects of RTX in⬇️regulating genes involved in immune cell recruitment, activation and organisation in ectopic GC #EULAR2021 #OP0136 @RheumNow https://t.co/FRUvo4JxTx
Md Yuzaiful Md Yusof @Yuz6Yusof( View Tweet )
Jun 03, 2021
Sjogren’s QoL reported dryness correlates with objective salivary flow ⭐️lower perceived dryness associated with higher immunologic activity Abs#POS0102 #EULAR2021 @RheumNow

Robert B Chao, MD @doctorRBC( View Tweet )

Jun 03, 2021

Sinusitis Activity Linked to Brain Dysfunction

Apr 13, 2021

Have you wondered why fibromyalgia, fatigue or cognitive dysfunction often co-associate with chronic sinusitis?



A case-control study of 22 patients with chronic rhinosinusitis published in JAMA Otolaryngology–Head and Neck Surgery found that sinonasal inflammation was

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Answering questions on how COVID-19 affects rheumatic patients

Nov 10, 2020

As we inch closer to a possible vaccine for COVID-19, we are finally filling in the details on how the pandemic is affecting every aspect of our patient’s lives.

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Don’t forget to check the eyes. Dr Kolfenbach. Top secret and Pearls #ACR20 @RheumNow It’s also useful for dx #sjogren #sarcoidodis #Ig G4 https://t.co/dxmwuwrPqz
Nov 08, 2020
Myths surrounding #sjogren. Complications of severe dry eye. Dr Akpek #ACR20 @RheumNow https://t.co/gnZJfcpsGn
Nov 08, 2020
Living with #Sjogren #syndrome. Tips for dry mouth management. Dr Papas #ACR20 @RheumNow @ramos_casals https://t.co/uw4NH3yhpn
Nov 08, 2020
#sjogren #syndrome poster session #ACR20 @RheumNow Clinical characteristics: lung, pregnancy,smoking, cervical lesions, anti La, childhood. https://t.co/QN4FVvQrYN
Nov 08, 2020
Management of elderly patients with rheumatic diseases. Dr Rajasimhan. #ACR20 @RheumNow. Also we are near of first therapeutic recommendations of elderly #sjogren syndrome @ramos_casals @p_brito_zeron https://t.co/yjGrSTWV1K
Nov 07, 2020
Editors Pick for #ACR20—Leflunomide–hydroxychloroquine combination therapy in patients with primary Sjögren's syndrome (RepurpSS-I): a placebo-controlled, double-blinded, randomised clinical trial https://t.co/cunDxVl5XG https://t.co/OGItXCuWDI
The Lancet Rheumatology @TheLancetRheum( View Tweet )
Nov 07, 2020
Lung disease in primary #SjogrensSyndrome is common; both conditions were diagnosed at the same time in 43% of patients, found an #ACR20 study from @joannamarco @GGRheumdoc + @UW @uofcincy colleagues. “Close monitoring is warranted” to make sure lung function is not declining. https://t.co/MpA0Rq2uVR
CreakyJoints.org @CreakyJoints( View Tweet )
Nov 06, 2020
Hand OA Rx strikes out. HCQ Rx neg and colchicine Trial negative. I wouldn’t put hand OA as same category of no Rx as for SSc and Sjogrens but agree though nuts to crack @eular_org @CRASCRRheum @earlyarthritis #EULAR2020 https://t.co/QRe3UpKpbz

Janet Pope @Janetbirdope( View Tweet )

Jun 07, 2020
#EULAR2020 OP0096 Dr. L Chatzis study on Sjogren: 1. 2nd most common autoimm dz in women 2. women:men ratio 20:1 (not 9:1) 3. 2 types Ro-Ab: nuc. Ro60 (assc w/La)and cytopls. Ro52 (assc w/ILD/myositis) 4. Seroneg. Sjogren's (neg Ro/La/RF) good prognosis:⬇️lymphoma @RheumNow https://t.co/fV3ltQqnkf
Jun 06, 2020
Primary Sjogren’s syndrome showed benefit of leflunomide + #Hydroxychloroquine vs placebo - past neg RCT of HCQ for PSS Sicca (dry eyes/mouth) so is it just leflunomide that works or combo? Likely pt selection - arthritis and rash likely respond to either @RheumNow @CRASCRRheum https://t.co/lsIeG2uv2H

Janet Pope @Janetbirdope( View Tweet )

Jun 06, 2020
Yet another NEGATIVE Trial in Hand OA. Add Hand OA to the list that Includes Scleroderma, Sjogrens and CRPS as untreatable diseases with large unmet needs! https://t.co/cMMqmeo19N

Dr. John Cush @RheumNow( View Tweet )

Jun 05, 2020

RheumNow Podcast- Corona Increases RA Risk (3.13.20)

Mar 13, 2020

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.

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Don't Blame the Weather in Sjogren's

Mar 03, 2020

Seasonal variations in symptoms -- commonly reported by patients with rheumatic diseases -- were not observed in a large cohort of patients with primary Sjogren's syndrome, French investigators found.



On a combined endpoint that reflected the three main symptoms of pain, fatigue, and

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