It's now called Sjögren Disease!

Jack Cush, MD

Aug 21, 2025 5:48 pm

Sjögren syndrome is now Sjögren disease, according to recommendations stemming from the 2023 International Rome consensus for the nomenclature of Sjögren disease.

Backed by a several year effort from the Sjogren’s Foundation, the switch from syndrome to disease was an international effort culminating in the 2023 Rome conference.

Many have been dissatisfied with the term Sjögren "syndrome" suggesting the diagnosis based on soft features, vague symptoms, or a poorly understood disorder. As many international experts will attest, such is not the case. Also limiting has been the distinction between ‘primary’ and ‘secondary’ Sjögren forms, failing to account for the complex interplay of overlapping autoimmune diseases.

The Rome conference was led by a steering committee of included 8 rheumatologists, 2 internal medicine specialists, 2 ophthalmologists, 2 oral medicine specialists, a pediatrician and 2 patient representatives. Following a bibliometric analysis, systematic literature review and a Delphi consensus process with equal involvement of professional and patient representatives, five recommendations were issued.

‘Sjögren disease’ should replace ‘Sjögren syndrome’
Acronym ‘SjD’ should be used as an abbreviation for ‘Sjögren disease’
The descriptor ‘associated’ should be used in lieu of ‘secondary’ for Sjögren disease occurring in association with a second systemic autoimmune disease
Sjögren disease is the preferred terminology in common parlance and in clinical diagnosis, without differentiation as to primary and associated (secondary) forms
Differentiation between primary and associated Sjögren is recommended for scientific studies to define a homogeneous population.

In conclusion, the consensus endorses ‘Sjögren disease’ as the official nomenclature to acknowledge the distinct pathogenesis of this disorder and to improve clarity in both clinical practice and research.

Sjogrens disease