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Steroids

Avacopan for ANCA Vasculitis Goes in Front of the FDA

MedPage Today
May 07, 2021

An FDA advisory panel will consider whether to recommend approval of an oral C5a inhibitor for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, with agency staff raising questions over the "clinical meaningfulness" of key study data.

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RheumNow Podcast – Falling or Falling in Love?

May 06, 2021

Dr. Jack Cush reviews the best journal articles from the past week on RheumNow.com.

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Childhood Lupus May Hamper Adult Careers

May 04, 2021

Long-term outcomes of kids with childhood-onset systemic lupus erythematosus (cSLE) are uncommon, but this cSLE cohort analysis suggests that SLE significantly impacts their future education, vocation, and employment as they reach adulthood.



A cohort of 106 cSLE (93% female, 73% White

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RheumNow Podcast – Uppers and Downers

Apr 30, 2021

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com.

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RheumNow Podcast – Coconspirators: RA and Lung Disease

Apr 23, 2021

Dr. Jack Cush reviews and discusses more than a dozen news and journal articles from the past week on RheumNow.com.

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DMARD Dropouts During COVID-19

Apr 12, 2021

A full year from the onset of the SARS-COV-2 pandemic, rheumatologists are still seeing the consequences of COVID, with many patients avoiding usual care, follow-up visits, routine lab testing and with many self-stopping their antirheumatic meds, because it seemed like the right thing to do

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RheumNow Podcast – Mistakes with Steroids

Apr 08, 2021

Dr Jack Cush gives his spin on this week's RheumNews and Rheum Research from RheumNow.com.

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Overview of New VEXAS Syndrome

Apr 08, 2021

Medscape offers up an informative overview of the newly described syndrome called VEXAS discovered by researchers at the National Institutes of Health. These patients were previously misdiagnosed with Sweets syndrome, relapsing polychondritis, myelodysplastic syndrome, MGUS, or polyarteritis

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From @KDAO2011 for #RNL2021 Is it better to taper the steroids or leave it? SEMIRA study. Tapering off low dose steroids cause more flares and more treatment side effects. Dr. Buttgereit says keep your low dose steroids (prednisone 5 mg/day or less) https://t.co/FpQnxUKWwF

Dr. John Cush @RheumNow( View Tweet )

Mar 30, 2021

Hypertension Unaffected by Urate Lowering Therapy

Mar 30, 2021

Does uric acid contribute to the risk of hypertension (HTN)?  A recent cohort trial shows that allopurinol in young adults does not sufficiently lower blood pressure (BP).



Previous research in a small cohort of obese hypertensive kids showed that urate lowering therapy was assoaciated

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“Give as much glucocorticoids as necessary but as little as possible!” – Dr. F Buttgereit #RNL2021 #RheumNow Original tweet from Dr. Kathryn Dao @KDAO2011

Dr. John Cush @RheumNow( View Tweet )

Mar 29, 2021

Serious Infections Still Common in Vasculitis

MedPage Today
Mar 29, 2021

Serious infections occurred more frequently among patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis who were given induction therapy with cyclophosphamide compared with rituximab (Rituxan), Greek researchers found.

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Potent Topical Corticosteroids and the Risk of Osteoporotic Fractures https://t.co/OHohMKveik

Dr. John Cush @RheumNow( View Tweet )

Mar 28, 2021

RheumNow Podcast – Infection in ANCA-Associated Vasculitis (3.26.2021)

Mar 26, 2021

Dr. Jack Cush reviews the news, FDA Denials and journal articles from the past week on RheumNow.com.




  1. Analysis of CPRD registry and 15,670 MTX treated pts (46,571 PYs) showed discontinuation for abnormal or severely abnormal labs was 42/1000PY and 6/1,000PY and half that

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UTSW Rheum Gran Rounds - Dr. Ken Saag, Anakinra vs IA steroids @UTSWIMchief @KenSaag https://t.co/M2UCbyuJpb
Dr. John Cush @RheumNow( View Tweet )
Mar 25, 2021

RECIPE Trial - Mycophenolate to Suppress Immunogenicity with Pegloticase in Gout

Mar 22, 2021

Pegloticase is indicated in the treatment of severe gout patients but prolonged use may be limited by immunogenicity to the PEG moiety. A randomized, controlled trial has shown that concomitant mycophenolate mofetil (MMF) may prolong the efficacy of pegloticase in gout.

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Early RA pts given steroids (GC) do Not have short or long term benefits from GCs. 180 ERA pts given compared to 294 who did not. 5 yr F/U showed no differences in DAS28-CRP, HAQ or pain between groups. Steroids were used more in seronegative RA. https://t.co/CDUKDgsLRa

Dr. John Cush @RheumNow( View Tweet )

Mar 22, 2021
News Feature: Potent Topical Corticosteroids and the Risk of Osteoporotic Fractures https://t.co/KazNPRXKNx https://t.co/pykBdbexzF
Dr. John Cush @RheumNow( View Tweet )
Mar 20, 2021
@RheumNow #RNL2021 Dr. Buttgereit on steroids in RA: 2.5 mg/d of prednisone increase total steroid amount in the body by 100% - great therapeutic effect but comes w/plethora of side effects. Q: how do you feel out long term low dose steroids for RA?

Olga Petryna @DrPetryna( View Tweet )

Mar 20, 2021

MDA-5 Antibodies and Juvenile Dermatomyositis

Mar 17, 2021

A multicentre, retrospective study examined MSA profiles (by immunoprecipitation) from 96 juvenile idiopathic inflammatory myopathies (JIIM) at nine pediatric rheumatology centres in Japan. MSA were found in 85 of 96 cases with over 90% of patients having one of the following three MSA types

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COVID-19-Related Deaths in Rheumatic Disease Patients

Mar 11, 2021

There is a growing body of evidence regarding COVID-19 outcomes (including death) in rheumatic disease patients; analysis of a German registry shows that poor control, rituximab, sulfasalazine and other immunosuppressives could be risk factors for COVID-related death.



The early data

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RheumNow Podcast – Sweet Lies or Hard Truths? (2.26.2021)

Feb 26, 2021

Dr. Jack Cush reviews and discusses the news and Journal reports from the past week on RheumNow.com.

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Cohort analysis of 12351 RA patients from CPRD registry - finds RA on both glucorticoids & PPI have a greater risk OP fractures (adj HR: 1.60, 95% CI: 1.35 to 1.89) vs non-use. Higher than the Fx Risk with either oral GC or PPI use alone (adj HR 1.2). https://t.co/oPMnJoHCjX https://t.co/eW7rpVeHa4
Dr. John Cush @RheumNow( View Tweet )
Feb 24, 2021
Analysis of incident #RA in UK Clinical Practice registry shows recent prednisone >=7.5mg/d is assoc w/ hypertension in RA. In 17760 RA pts, 42% were Rx steroids; recent GC yielded a 17% increase in HTN (HR 1.17); only >7.5mg/D implicated https://t.co/qUKs2oZZUV https://t.co/pWmD4nKs6U
Dr. John Cush @RheumNow( View Tweet )
Feb 22, 2021

High Risk Cancer Profiling with Inflammatory Myositis

Feb 18, 2021

A recent metanalysis of studies suggest you may be able to use certain clinical factors to stratify cancer risk in patients with idiopathic inflammatory myopathies (IIMs).

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