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ACR21 Best Abstracts - Day 1
The RheumNow faculty have been glued to their monitors all day, watching video, and running down abstract presentations to find the best – several of these stood out as #ACRBests. Here is a listing of “Best” they saw on Day 1.
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Opening Day Report
The opening of ACR2 Convergence was a hit for all who signed up and viewed in. The day included the presidential address by outgoing president Dr. David Karp (UT Southwestern) and a keynote talk and interview with Dr. Seema Yasmin (Stanford).
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Dr. P Crow #PhilipHench provides a tour of research on SLE pathogenesis:
👉discovery of Ab to small nuclear RNAs and the spliceosome
👉T cells' role on B cell differentiation
👉⬆️CD40L on SLE lymphocytes
👉IFN genes and their effects on the immune system #ACR21 @rheumnow https://t.co/6v9O19UUxX
TheDaoIndex KDAO2011 ( View Tweet)
Dr. P Crow #PhilipHenchLecture
IFN signature can parallel or predict flares #ACR21 @rheumnow https://t.co/OskxDuKPDH
TheDaoIndex KDAO2011 ( View Tweet)
Soluble urinary ALCAM previously shown as potential biomarker for LN. Further study showing urinary ALCAM trended with changes in renal-SLEDAI and UPCr.
#ACR21 Abst#3053 @RheumNow https://t.co/IqVJej7yda
Links:
Pedro Castillo _Castillo_Pedro ( View Tweet)
Important to discuss men with #lupus
Nationwide claims study showed increased occurrence of multimorbidity in men with SLE compared to women with SLE #ACR21 @RheumNow @AliDuarteMD Abst#0579 #ACRBest https://t.co/ljflGU84Ro
Bella Mehta bella_mehta ( View Tweet)
Ear dyspigmentation, scalp dyspigmentation and scarring alopecia found more frequently in Black DLE pts. Findings may help assist in dx and tx plans. Abs 0598 #ACR21 #RheumNow #ACRbest @RheumNow https://t.co/a1pxWHJ7b5
Dr. Rachel Tate uptoTate ( View Tweet)
Factors associated w/ poor COVID19 outcomes in #SLE from the GRA @rheum_covid
📌Demographics - age, sex, region
📌Glucocorticoid use
📌 Comorbids - renal, CV
📌Untreated/active dse
❗Very important msg here: Control dse, manage comorbids & avoid GCs
@RheumNow #ACR21 abs0866 https://t.co/eXR3KqGrJa
sheila RHEUMarampa ( View Tweet)
#SLE pts will.... answer in abst#0858 #ACR2021 @RheumNow
Janet Pope Janetbirdope ( View Tweet)
Good news for #COVID vaccine in #SLE. ✅doesn’t cause #lupus flares ➡️ no increase in APS. What about #SARS-CoV2 infection in SLE. Flares ↔️ stable but ⬆️APS Abs. from Hopkins cohort. Petri #ACRBest #ACR21 abst0858 @RheumNow https://t.co/ABx4C4lwvs
Janet Pope Janetbirdope ( View Tweet)
Dr. Petri noted that 1 week off of immunosuppressants is adequate for most lupus patients to mount a response. She avoided RTX during the pandemic. In pts who have had inadequate response to 2 or 3 doses of mRNA, she switches them to J&J. #ACR21 #COVI19 CH @rheumnow https://t.co/qNjmx9uTLF
TheDaoIndex KDAO2011 ( View Tweet)
HSS Study of 136 SLE flares post-vax:
👉100 (74%) w/expected AE (headache/myalgias)
👉11 (8.1%) pts with SLE flare
👉Majority of flares were mild-mod & occurred w/in 1 week of vaccination
👉Most resolved w/in 7 days.
Abst#0896 #ACR21 @rheumnow
https://t.co/e6AP8PPRH2
TheDaoIndex KDAO2011 ( View Tweet)
Dr. Katie Liao presented an observational study comparing SLE pts who were Ro neg (n=208) vs Ro pos (n=185).
More of the (+)Ro pts had:
⬆️Adjusted mean SLEDIA >4
⬆️Proteinuria
⬆️Neutropenia,+RF, +dsDNA, and low C3 or C4
⬆️Discoid or malar rash
#ACR21 Abst#0323 @RheumNow
Pedro Castillo _Castillo_Pedro ( View Tweet)
Distinguishing between #preeclampsia and #lupus nephritis flare in 🤰 #SLE patients is very important because management is different. #rheumatology #medtwitter https://t.co/Dc9ohJQ75L
sheila RHEUMarampa ( View Tweet)
#ACR21 #Abstr0336 ANA is not a great test for #lupus diagnosis. Multianalyte Assay Panel with Cell-Bound Complement Activation Products could improve diagnosis (OR 6.3) and Drug Initiation (OR 2.8). Can we speed up implementation to clinic? #RheumNow https://t.co/jLcAtD7FaY https://t.co/YmLwmVWp6k
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
#GreatDebate: add belimumab (BLMB) vs. voclosporin (VCS) to MMF for lupus nephritis (LN)
Dr. Petri argues for BLMB b/c: (1/2)
👉improvement in LN
👉improvement in non-renal lupus
👉decrease lupus renal mortality
👉**prevent GFR reduction **
👉long term efficacy
#ACR21 @rheumnow
TheDaoIndex KDAO2011 ( View Tweet)
Abst#0858 Hopkins SLE Cohort 860 pts, 65 w/COVID19, 228 vax'd:
👉COVID19 infx did not increase dz activity, but aPLs were increased (rash decreased likely d/t quarantine and no sun exposure)
👉COVID19 vaccine did not affect dz activity #ACR21 @rheumnow
https://t.co/C65qJuMIbk
TheDaoIndex KDAO2011 ( View Tweet)
And I’m finally in the game!! On board for #ACR21
Enjoying hearing Virginia Pascal showing data on how opsonisation of red blood cells containing mitochondria results in the induction of Type I Interferon pathways
Great paper here https://t.co/QWJLncYmC3 #ACRambassador
Chris Wincup chriswincup ( View Tweet)
#ACR21 - Dr. Virginia Pascual speaking on #PrecisionMedicine in Lupus. Mitochondria in RBC's will cause more disease activity in Lupus patients. Th groups that remove Mitochondria have less disease activity. Hope this takes us to #precisionmedicine soon!. #Looms4Lupus https://t.co/sMOmeJPMJX
Looms4Lupus Looms4Lupus ( View Tweet)
#ACR2021 Dr. L Sammaritano shows evidence for using belimumab during breastfeeding @RheumNow https://t.co/kDXXauoOZQ
Donald Thomas, MD lupuscyclopedia ( View Tweet)
