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ACR 2025 – Day 2 Report

d Jack Cush, MD

Here are 3 abstracts that caught my eye on Day 2 at ACR25. Notably these have takeaway messages that should support your current practices.

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ACR Best

ACR25 Best Abstracts - Day 2

d Jack Cush, MD

After a full day at the Chicago Convention center the RheumNow faculty have posted some of their favorite reports included these that they labeled as being the "best' of day 2.

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CAR-T

Are we putting the CAR-T before the horse?

d Richard Conway, MBBChBAO, PhD

CAR T-cells have been a revolutionary development in rheumatology. We have seen a population of patients with severe refractory autoimmune conditions almost overnight presented with the prospect of not just improvement, but of a cure.

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question marks

Psoriatic Arthritis: Which biologic agent is the best first choice?

d Brian Jaros, MD

A growing arsenal of therapeutic targets in psoriatic arthritis (PsA) has enhanced the landscape of treatment in patients with this disease.

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SLGT-2 and GLP-1 in RA: More than Weight Loss https://t.co/SRKMHNlHZo Future of rheumatology is bright , Shreya Sakthivel discussed her work on TriNetX database , looking specifically for effect of SLGT-2. GLP-1 on RA flare incidence. @RheumKay @RheumNow #acr25

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Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)

GLP-1 in Knee Osteoarthritis https://t.co/SxyVEAK1CZ @bella_mehta Discusses role of GLP1 in OA and possible mechanisms of effectiveness ? weight reduction ? or doses it have anti-inflammatory -anti-fibrotic role ? @RheumNow #ACR25

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Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)

Progressive BiTE in SLE 2 https://t.co/ykMQmSAdlb More on BiTES in SLE by the one and only @Yuz6Yusof Bi specific Tcell engager ( CD3-CD19). @RheumNow #ACR25

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Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)

New Paradigms in RA Treatment https://t.co/CqpI2znglE @jeffsparks Highlights new trials in RA 1-Neuro immune modulation ( Vagal nerve stimulation). 2-Targeting pathogenic T cells 3-T reg CAR-T ( Peace maker). @RheumNow #ACR25

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Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)

Day 2 Recap: ACR Convergence 2025 Highlights https://t.co/b8XvrEsoLW Such a great time to be a rheumatologist. Fake rheumatology sounds like a great topic! Daily challenges and unusual presentations. @DrMiniDey @synovialjoints @drdavidliew @RheumNow #ACR25

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Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)

#ACR25 Abstr#0855 Five extra patients were added to complete IMPACT Open Label Phase 2 trial of add-on Certolizumab in APS women + LAC+ve. Results stood: primary endpoint was met (adverse pregnancy outcome=19.6%; lower than 20% expected). Significant enough to adopt @RheumNow https://t.co/zhFVGYXiaU

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Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
RheumNow’s expanded coverage of the #ACR25 annual meeting is sponsored by Bristol Myers Squibb, Novartis, and UCB. All coverage content is independently selected by RheumNow and its faculty.

Dr. John Cush RheumNow ( View Tweet)

#ACR25 Day 1 RECAP Big takeaways, standout moments, and what set the tone for this year’s conference. We break down the key insights, early trends, and conversations shaping Day 1. https://t.co/js5FVBvUfk https://t.co/smh1AyPhfa

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Dr. John Cush RheumNow ( View Tweet)
Stress Raises the Risk of Psoriasis New longitudinal research reveals that severe stress caused by changes in family structure like divorce or separation experienced during the first year of life may triple the risk of developing psoriasis later in life. https://t.co/TSXoQKjRPN
Dr. John Cush RheumNow ( View Tweet)
In a retrospective study of TAK patients, ~about 1/3 developed new lesions on imaging over time Most lesions: - stenotic - L carotid - Abdominal aorta - SMA 50% of the 1/3 = 2 or more lesions Serial imaging is crucial! @RheumNow #ACR25 Abst 1631

Brian Jaros, MD Dr_Brian_MD ( View Tweet)

How does DADA2 present? Ten studies provided data on a total 225 patients 1) skin findings 2) fever 3) stroke 4) cytopenias @RheumNow #ACR25 Abst 1615 https://t.co/xZuTk6YFdJ

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Brian Jaros, MD Dr_Brian_MD ( View Tweet)
PET and histologic discordance in aortitis Of 5 aortitis patients who had PET/CT prior to aortic surgery with path, only 1 showed concordance (neg PET, neg biopsy) 4/5 patients had inflammatory biopsy with neg PET Small # but PET is not perfect! @RheumNow #ACR25 Abst 1620

Brian Jaros, MD Dr_Brian_MD ( View Tweet)

ACR2025 Day 2 Recap https://t.co/TtGVddjsyJ

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Dr. John Cush RheumNow ( View Tweet)

Delay in PsA diagnosis Meta Analysis of 32000+ pts Median diagnostic delay 2.5 years Median delay in referral 1 year Increase odds of Rx damage from 50% Geographic variation We need to do better #ACR25 @RheumNow #ABSTRACT1713 https://t.co/CWwqosa5NT

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Aurelie Najm AurelieRheumo ( View Tweet)
PMR patients need healthcare professionals who know a bit about their disease. Survey of US HCPs, amongst responders: - 68% were not aware/unsure about PMR - of those who were aware, knowledge was… not great (see below) PMR needs everyone’s respect #ACR25 ABST1617 @RheumNow https://t.co/SpyEnAW8lI

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David Liew drdavidliew ( View Tweet)
A largely understudied area: Impact of peri-menopause in PsA Toronto Cohort 473pts, HRT 1.5% Peri menopause = increase DAPSA, TJC, SJC, FACIT-fatigue, HAQ compared to pre- and post-menopause No association w/ BMI, but with fatigue Less impact when education level increases https://t.co/bSuGxZCbGn

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Aurelie Najm AurelieRheumo ( View Tweet)
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