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RheumNow Podcast – ACR 20 is Coming to Town (10.30.20)
Dr Jack Cush overviews the RheumNow commitment, upcoming bonus coverage of ACR20 and the good news and journal reports from the past week on RheumNow.com
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Fibromyalgia Therapies Show Limited Evidence of Pain and QOL Reduction
JAMA Internal Medicine has published a review showing that most currently approved therapies for fibromyalgia (FM) do not have high-quality evidence to support their use; with some reducing pain or improving quality of life (QOL) in the short term, but overall effect size is not impressive.
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Dr. Kathryn Dao ( @KDAO2011) reviews abstract #0533 presented at #ACR20 on male osteoporosis.
https://t.co/Z0NLcJzslV https://t.co/SSoIA7Eetg
Links:
Dr. John Cush RheumNow ( View Tweet)
We are underdiagnosing this!
In pts with persistently low ALP, think hypophoshatasia (HPP); these pts have recurrent poor healing fractures, may have CPPD, and have been refractory to standard OP Rx.
Dr. A Abelson #ACRReview @rheumnow #ACR20 https://t.co/dVptFkYXR2
k dao KDAO2011 ( View Tweet)
Dr. A Abelson #ACRReview @rheumnow #ACR20
Romosozumab (sclerostin Ab) for OP:
👉can be used after previous treatmt with PTH analogs
👉can be used in pts with prior radiation exposure
👉not yet approved for men.
Some slides on what to choose for OP and when to choose it https://t.co/nAbOmEjx3p
k dao KDAO2011 ( View Tweet)
from #ACR20 Dr. Abbey Abelson. There was reduction in hip fractures in the US until there was drop in reimbursement for DEXA/Bone Density. @ACRheum has been advocating on Capitol Hill to restore reimbursement. Bad policy harms, but good policy can save lives.
#ACRambassador https://t.co/ARo762Vozp
Suleman Bhana, MD DrBhana ( View Tweet)
ARCH study -- n~4100
Romo vs Alendronate x 12 mo
Alendronate 12-24 mo
RRR 38% https://t.co/d0G7x4TqUT
Vaneet K Sandhu, MD vksandhumd ( View Tweet)
How do we square up bone loss and new bone formation in AS? Are these coupled? Study from the ASSERT trial showed no relationship between baseline BMD and new syndesmophyte formation in the same vertebra @RheumNow #ACR20 Abstr#1896
Dr. Antoni Chan synovialjoints ( View Tweet)
Study of Chinese pts on long-term GCs by Dr CC Mok: DEN >> ALN in ⬆spinal BMD & suppressing bone turnover markers after 1yr tx.
No sig. diff in AEs among grps.
Limits: Open-label,small ss,short tx dur'n, not powered for fractures @RheumNow #ACR20 abs1442 https://t.co/m8mT0hMPN8
sheila RHEUMarampa ( View Tweet)
#ACRKnowledgeBowl #acr20 @rheumnow
This % of bone loss is assc with a T-score -1.5 on a DXA
k dao KDAO2011 ( View Tweet)
Re Abs#760: Bone erosions in +CCP not predictive of development of IA. You have a pt with no synovitis, but +CCP, small bone erosion on standing foot xray. Do you treat? #ACR20 @Rheumnow
Eric Dein ejdein1 ( View Tweet)
Dr Hansen at 3S008 on "Bone for the Holidays": individualize the decision for drug holidays - here are the key questions: #acr20 @Rheumnow https://t.co/lMHtYW4OzE
Eric Dein ejdein1 ( View Tweet)
Great talk by @lovetolearn27 Prosthetic joint infection doubles the risk of venous thromboembolism after revision of knee replacement. 15 yr data New York state -25K revisions! @RheumNow #ACR20 ABS#0960 https://t.co/4PHHSEstKs
Bella Mehta bella_mehta ( View Tweet)
Presenting work by @drdj & I showing "Risk Factors for Lumbar Vertebral #Osteoporosis Do Not Reflect Factors Traditionally Associated with Osteoporosis at the Hip."
🗓️Session: #Epidemiology & #PublicHealth Posters II
⏰1400 GMT/ 0900 ET today!
🗒️Abs#0544
#DEXA #ACR20 @RheumNow
Mrinalini Dey DrMiniDey ( View Tweet)
Kaiser Permanente AFF study takeaways:
- risk of atypical #fracture ⬇ vs. other clinical fractures
- ⬆ risk in Asians
- consider drug holidays for pts on bisphosphonates
@RheumNow #ACR20 https://t.co/mq9zIh2iD5
sheila RHEUMarampa ( View Tweet)
@JYazdanyMD @UWRheum @r_burmester Black, et al - cont'd
277 atypical femur fx events
Risk increased w longer duration of bisphosphonate use
Risk decreased after bisphosphonate discontinuation
Asians had a higher risk than Whites.
#ACR20 #ACRambassador
Rheum Cat rheum_cat ( View Tweet)
Population study from NY of 168,234 hip replacements and 308,477 knee TKAs showed that total joint arthroplasty was associated with a 34-44% decrease risk of falls (THA HR 0.56; TKA HR 0.66). Risk of falls incr w/ age- 70-79 yrs (HR4.3), 80+ yrs (HR 5.5) https://t.co/KeejsfGEjn
Links:
Dr. John Cush RheumNow ( View Tweet)
Listent to QD Clinics - A Podcast Weekly Compilation - Lessons from the clinic. Dr. Jack Cush discusses triage Rheumatology; Im Not Stupid; & Swollen but Not Painful
iTunes https://t.co/FHJv01Sb3a
SoundCloud https://t.co/fceBeXGu09
Dr. John Cush RheumNow ( View Tweet)
Korea National Health databased looked at Fracture rates in RA patients taking TNFis, abatacept, or tocilizumab betw 2002 to 2016. They found no difference in Fx risk related to the biologic taken. https://t.co/W2dWWseXTc
Links:
Dr. John Cush RheumNow ( View Tweet)
Not sure why this study was done...BUT... Tociiizumab was studied in 104 hand osteoarthritis and after 12 weeks, TCZ was equivalent to Placebo in achieving100mm VAS pain reduction (-9.9 vs -7.9), but TCZ had numerically more adverse events https://t.co/NYujNQbjvm
Links:
Dr. John Cush RheumNow ( View Tweet)
