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RheumNow Podcast – Saphnelo (Anifrolumab) Approved for Lupus (8.6.2021)

Aug 06, 2021 7:17 am

Dr Jack Cush reviews the news, journal reports and FDA approvals from the past week on RheumNow.com

  1. Veterans study gout prevalence rose from 4.2% to 5.8%, 2005 to 2014. 2014, 4.0% of all inpatient/outpatient encounters & 1.3% of hospitalizations were gout related. ULT use remained stable with 46% of gout patients receiving ULT https://bit.ly/2Vrnq8g

  2. Study of 1821 pregnant women with autoimmune disorder. 74% used acetaminophen during pregnancy (HA, pain, injury). The highest (5th quintile use thru wk 20) acetaminophen had a modest risk (HR 1.62) of preeclampsia vs none https://bit.ly/3ftyM2f

  3. A prospective, longitudinal study of the cognitive development of children born to mothers with rheumatoid arthritis (RA) demonstrates normal development as measured by comparative school test scores. https://t.co/6Dfdnin1aI

  4. Retrospective study of 80 kids w/ systemic JIA - 12 pts changed anakinra to cananinumab & continued w/ clinical inactive Dz (CID). 68 active sJIA Rx w/ CAN: 57% CID off GCs at 6 mos & 64% at 12 mos. NonResponse predicted by #active jts ≥5, hx of MAS https://t.co/QkmqzRrjp6

  5. Systematic review of Kawasaki Dz treatment (4 RCTs, 456 pts) shows MAb & anti-cytokine biologic use does not reduce Coronary artery abnormalities (RR 0.93; [95%CI], 0.65 to 1.32) vs IVIG, but Abs did reduce Rx resistence (RR 0.60) https://t.co/FJkQfxCkjB

  6. Serum adipokine CTRP9 levels may predict severe lung dz in Systemic Sclerosis (SSc-ILD): Retrospective longitudinal Registry/Biorepository study; 110 SSc pts - 31% had elevated CTRP9 assoc w/ lower FVC. Low CTRP9 assoc w/ FVC Stability. https://t.co/AY4U12kwPr

  7. A retrospective analysis of the ACR RISE registry shows that multimorbidity is not only common in patients with active rheumatoid arthritis (RA), but also impacts treatment choices and outcomes.  https://t.co/72Lcqxjoly

  8. Study from the UK BSRBR for #AS & 2043 pts showed 44% w/ at least 1 comorbidity. Each comorbidity was associated w/ 0.40 unit increase in BASDAI and 0.53 in spinal pain. More Dz activity w/ Depression, CHF and peptic ulcer, not CRP/ESR https://t.co/0vAnbjHicw

  9. JRheum review: 40–50% of psoriasis pts have psoriatic nail disease NP. NP is an important predictor of enthesitis, which is associated with the early stages of PsA https://t.co/sEuih3CSgX

  10. Cohort study of 66 874 postmenopausal women older than 50 years finds fracture to predict a greater risk of subsequent fracture (regardless whether 1st fracture was traumatic or nontraumatic). All such pts need OP assessments https://t.co/EQtDdZb8Vz

  11. FDA Approves Anifrolumab in SLE

  12. Back Talk – Zoster with Baricitinib

Check out last week's RheumNow Podcast: Psoriatic Arthritis without Psoriasis, and visit our Podcast page for other episodes. 

Disclosures
The author has no conflicts of interest to disclose related to this subject

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