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RheumNow Podcast – Saphnelo (Anifrolumab) Approved for Lupus (8.6.2021)

Aug 06, 2021 7:17 am

Dr Jack Cush reviews the news, journal reports and FDA approvals from the past week on

  1. Veterans study gout prevalence rose from 4.2% to 5.8%, 2005 to 2014. 2014, 4.0% of all inpatient/outpatient encounters & 1.3% of hospitalizations were gout related. ULT use remained stable with 46% of gout patients receiving ULT

  2. Study of 1821 pregnant women with autoimmune disorder. 74% used acetaminophen during pregnancy (HA, pain, injury). The highest (5th quintile use thru wk 20) acetaminophen had a modest risk (HR 1.62) of preeclampsia vs none

  3. A prospective, longitudinal study of the cognitive development of children born to mothers with rheumatoid arthritis (RA) demonstrates normal development as measured by comparative school test scores.

  4. Retrospective study of 80 kids w/ systemic JIA - 12 pts changed anakinra to cananinumab & continued w/ clinical inactive Dz (CID). 68 active sJIA Rx w/ CAN: 57% CID off GCs at 6 mos & 64% at 12 mos. NonResponse predicted by #active jts ≥5, hx of MAS

  5. Systematic review of Kawasaki Dz treatment (4 RCTs, 456 pts) shows MAb & anti-cytokine biologic use does not reduce Coronary artery abnormalities (RR 0.93; [95%CI], 0.65 to 1.32) vs IVIG, but Abs did reduce Rx resistence (RR 0.60)

  6. Serum adipokine CTRP9 levels may predict severe lung dz in Systemic Sclerosis (SSc-ILD): Retrospective longitudinal Registry/Biorepository study; 110 SSc pts - 31% had elevated CTRP9 assoc w/ lower FVC. Low CTRP9 assoc w/ FVC Stability.

  7. A retrospective analysis of the ACR RISE registry shows that multimorbidity is not only common in patients with active rheumatoid arthritis (RA), but also impacts treatment choices and outcomes.

  8. Study from the UK BSRBR for #AS & 2043 pts showed 44% w/ at least 1 comorbidity. Each comorbidity was associated w/ 0.40 unit increase in BASDAI and 0.53 in spinal pain. More Dz activity w/ Depression, CHF and peptic ulcer, not CRP/ESR

  9. JRheum review: 40–50% of psoriasis pts have psoriatic nail disease NP. NP is an important predictor of enthesitis, which is associated with the early stages of PsA

  10. Cohort study of 66 874 postmenopausal women older than 50 years finds fracture to predict a greater risk of subsequent fracture (regardless whether 1st fracture was traumatic or nontraumatic). All such pts need OP assessments

  11. FDA Approves Anifrolumab in SLE

  12. Back Talk – Zoster with Baricitinib

Check out last week's RheumNow Podcast: Psoriatic Arthritis without Psoriasis, and visit our Podcast page for other episodes. 

The author has no conflicts of interest to disclose related to this subject

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