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Vitamin D has No Effect on Knee Osteoarthritis
Vitamin D supplementation for individuals with knee osteoarthritis and low 25-hydroxyvitamin D levels did not reduce knee pain or slow cartilage loss, according to a study appearing in the March 8 issue of JAMA.
Subclinical Synovitis in Psoriasis Portends Future Psoriatic Arthritis
It is estimated that nearly 30% of psoriasis patients will develop psoriatic arthritis (PsA). This prevalence was studied by performing MRI scans on asymptomatic psoriasis (n=56) and 30 control patients without arthritis.
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ASAS: MRI Definition of Active Sacroiliitis
Increased use of MRI for diagnosis of spondyloarthritis (SpA) in the last two decades has led to earlier diagnoses and gradual incorporation of MRI into the SpA assessment toolset.
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Ultrasound Training Escalates in the United States
A recent report cites the frequency of musculoskeletal (MSK) ultrasound (US) education in US residency and fellowship training programs.
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Ultrasound Predicts Inflammatory Arthritis in CCP+ Persons Without Synovitis
A prospective study of 136 people who were CCP+, but who had no clinical evidence of synovitis, examined what factors may predict future development of inflammatory arthritis.
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PML is Very Rare in Lupus
A systematic review of the literature was done to assess the relationship between immunosuppressive therapy, adult systemic lupus erythematosus (SLE) and the onset of progressive multifocal leukoencephalopathy.
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MRI Bone Marrow Lesions Predict Worse Outcomes in Osteoarthritis
Medical Research Council study shows MRI lesions may predict which patients will have more rapidly progressing osteoarthritis.
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Top 5 and Bottom 5 Joints (Best of 2015)
Who knows or ponders the articulations (joints) more so than the rheumatologist or orthopedist? We know their anatomy, their contours, tender sites and how to examine them. Adults have over 200 bones and up to 360 joints. Imagine if you had to do a DAS360?
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Can Gout and Rheumatoid Arthritis Coexist?
German investigators studied 100 RA patients with a uric acid > 6 mg/dl and assessed them for MSU crystal deposit with dual energy computed tomography (DECT) of both feet and hands.
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DRIVE Trial: Denosumab and Methotrexate Prevent Joint Erosions
Joint erosions in RA result from a complex process with multiple contributing mechanisms. One of those mechanisms involves RANK receptor activation by RANKL leading to osteoclast differentiation, activation and survival.
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UCSF Study Shows Weight Loss Protects OA Cartilage
Researchers at the University of California at San Francisco have shown that >10% weight loss may impact the rate of cartilage loss as determined by MRI scanning. They presented their findings yesterday at the annual meeting of the Radiological Society of North America (RSNA).
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Interstitial Lung Disease Not Increased with Biologics
Extraarticular manifestations affect more then half of rheumatoid arthritis (RA) patients, and interstitial lung disease or "RA lung" is one of the more prevalent. The frequency of ILD in patients with RA varies from 5% to 58%.
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Power Doppler Ultrasound Detects Early Synovitis Change in APPRAISE Study
While new recommendations suggest early aggressive management of rheumatoid arthritis, our ability to assess treatment response is limited to clinical and laboratory assessment.
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Biology of Bone Remodeling in Psoriatic Disease
Paine and Ritchlin have reviewed the evidence that new bone formation is centered around enthesial sites and that such findings are evident in psoriatic arthritis as well as psoriasis patients without arthritis.
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Is Baricitinib Really Better Than Adalimumab in RA: Trial Results Reviewed
Dr. Peter Taylor and colleagues presented their results of the 52-week BEAM trial wherein baricitinib (a JAK 1, 2 inhibitor) was compared to adalimumab in both clinical and radiographic outcomes. This was the most viewed abstract online at the ACR website.
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Chondroitin Superior to Celecoxib in Knee OA Cartilage Loss
A study of 194 knee OA patients received either 1200 mg chondroitin sulfate or celecoxib 200 mg daily, and clinical and MRI outcomes were assessed at 1 and 2 years.
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Vertebral Fractures in 10% of Spondyloarthritis Patients
Vertebral fractures are not uncommon in patients with ankylosing spondylitis and spondyloarthritis.
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Diet, Exercise and Glucosamine Fail to Prevent Knee Osteoarthritis
Primary prevention of osteoarthritis is an ideal goal for which there has been little success in clinical trials.
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Is DLCO Predictive in Rheumatoid Interstitial Lung Disease?
Interstitial lung disease (ILD) is a common extra-articular manifestation of rheumatoid arthritis (RA). Its presence may portend grave outcomes for those affected. The prevalence of ILD in RA ranges from 7.7% to 44% depending on the assessment tools used.
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Is Early Use of TNFi in Spondyloarthritis Overkill or a Necessity?
Axial SpA (axSpA) is a chronic inflammatory disease that includes AS and non-radiographic axSpA (nr-axSpA).
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