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Mycophenolate in New-Onset SLE
How aggressively do you treat newly diagnosed new-onset systemic lupus erythematosus (SLE), or should you wait for organ involvement?
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TREAT EARLIER - Methotrexate in Clinically Suspect Arthralgia Patients
Lancet Rheumatology has published the results of the TREAT EARLIER trial, showing the prevention of rheumatoid arthritis may be enhanced by risk stratification, particularly in anti-citrullinated protein antibody (ACPA)-negative people with clinically suspect arthralgia.
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Antidepressants for Pain are Weakly Effective
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EurekAlert!
University of Sydney research has found people over 65 are being prescribed antidepressants as pain treatment based on international guidelines that use limited evidence. The study found that in the last 40 years there have been only 15 trials globally focusing on the benefit of antidepressants for pain in older people. This study fills a much-needed gap in research by bringing together the information from these trials to look at the efficacy and harms of antidepressants for acute and chronic non-cancer pain in those over 65 years old.
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FOREMOST: Apremilast in Early Oligoarticular Psoriatic Arthritis
A controlled trial has shown that apremilast is effective in patients with early, oligoarticular psoriatic arthritis (PsA).
IMPORTANT: Cost effectiveness analysis of the TREAT EARLIER RCT shows 88% probability that 1 yr of MTX in 236 pts w/ clinically suspect arthralgia was cost-effective. Results shows MTX Rx increased quality adjusted life years & reduced costs https://t.co/1BVxs77vo8 https://t.co/uQSQL5Eww9
Dr. John Cush RheumNow ( View Tweet)
Study of 115 systemic sclerosis (SSc) pts followed 4 yrs. modified Rodnan skin score @ 4 yrs correlated w/ baseline mRSS & finger-to-palm distance (length from the distal tip of the fourth finger to the distal palmar crease) https://t.co/TwMy5Mh68r https://t.co/4qhhBS9yOH
Dr. John Cush RheumNow ( View Tweet)
Study extended - People with #lupus #SLE: We'd love to hear about your experiences. Either use the link below or scan the QR code with another device. https://t.co/gbmn8PWbwd https://t.co/MHLbDdCGbf
Links:
Julia Simard, ScD RheumEpi ( View Tweet)
Cancer presenting as Inflammatory low back pain? 34 Cases presenting as SpA over 10 yrs often w/ higher ESR/CRP/LDH levels. CA included myeloma, leukemia, lymphoma, CA of breast/lung/prostate & bone tumors. https://t.co/YYKYx39tbD https://t.co/m9uCbJBsnU
Dr. John Cush RheumNow ( View Tweet)
Voclosporin and Steroids in Lupus Nephritis
Dr. Jack Cush reports on abstract OP0059 presented at Eular 2024 in Vienna, Austria.
https://t.co/4CilABzEjm https://t.co/hgyDqG1fPR
Dr. John Cush RheumNow ( View Tweet)
So You've Got RA and Want to Get Pregnant?
Dr. David Liew reviews abstract POS0436 presented at Eular 2024 in Vienna, Austria.
https://t.co/vG9l7kOReq https://t.co/xhumOCisOM
Dr. John Cush RheumNow ( View Tweet)
Congrats to 2024 recipients of the Lupus Research Alliance Diversity in Lupus Research Awards:
- Carlos Castrillon PhD, Emory
- Paul Hoover MD, PhD, Brigham
- Renita Horton PhD, U Houston
- Rodrigo Cervantes-Díaz PhD, Boston Childrens
- Jonathan Lagos Orellana MD PhD, Seattle… https://t.co/gtvT4kt7Lt https://t.co/MOdxH2cPM1
Dr. John Cush RheumNow ( View Tweet)
2612 BSRBR-RA Registry pts on tocilizumab - increasing Body weight was associated with reduced DAS28 response to SC tocilizumab. But the DAS28 difference was small, and did not change drug persistence https://t.co/eR7kmjRaEE https://t.co/vFKYC1I3pV
Dr. John Cush RheumNow ( View Tweet)
Chinese study of 62 Systemic JIA pts Rx w/ IV Tocilizumab (34 12 mg/kg; 28 8 mg/kg). Wk12 87% responded (JIA ACR 30w/ no fever); Week 52 results were similar. No deaths or macrophage activation syndrome occurred. https://t.co/qGgMCt597x https://t.co/lFDxAgDHfW
Dr. John Cush RheumNow ( View Tweet)
Swedish population/registry study of incidence of Psoriatic arthritis was estimated at 21.8/100 000 person-years (15.78-28.83/100 000 PY); slightly higher in females, lower w/ higher education, peaks 50-59y. 71% were on DMARD w/in 2 yrs (22% b/ts DMARDs) https://t.co/YTNBHczZ7X https://t.co/KNscF08fKG
Dr. John Cush RheumNow ( View Tweet)
Retrospective Taiwan's Health claims: studied 6408 RA pts, half HCQ users vs non-users. No higher risk of osteoporosis in HCQ users vs non-users (aHR=0.99; 95% CI: 0.82–1.196). Why study this? HCQ may suppress both bone formation/resorption https://t.co/xShLXMElnH https://t.co/lkvihaYuAd
Dr. John Cush RheumNow ( View Tweet)
Different Autoantibody Phenotypes in Juvenile and Adult Myositis
A Kyoto University study compared juvenile-idiopathic inflammatory myopathy (IIM) and adult-IIM patients, demonstrating different autoantibody profiles and a more favorable outcome for n juvenile-IIM patients.… https://t.co/fHL14rXAQ6 https://t.co/ZagRU62joJ
Dr. John Cush RheumNow ( View Tweet)
Systemic Sclerosis Insights (9.13.2024)
https://t.co/fRbKdSAqxG https://t.co/PMbYDXPHMd
Dr. John Cush RheumNow ( View Tweet)
Congratulations to UCF Associate Professor Justine Tigno-Aranjuez for receiving prestigious U.S. National Science Foundation CAREER Award on her research into NOD2 receptor signaling of lipid mediators contributing to inflammation https://t.co/AkUZbdTSqF https://t.co/usTe2bzyXE
Dr. John Cush RheumNow ( View Tweet)
24 wk RCT of 683 chronic neck pain pts -acupuncture was more effective in reducing neck pain than sham or waiting (observation), but the magnitude of benefit was below the minimal clinically important change. https://t.co/sqNV8XFYRl https://t.co/hI5Y3z6JiK
Dr. John Cush RheumNow ( View Tweet)
“Big doors swing on little hinges.”
- W. Clement Stone https://t.co/wLfKpwUxzc
Dr. John Cush RheumNow ( View Tweet)