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RheumNow Week in Review – 27 May 2016
Dr. Cush reviews highlights from this week on RheumNow.com.
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Tocilizumab Effective in PMR
Polymyalgia rheumatica (PMR) should be easy and responsive, but it can be a challenge and requires long-term steroid therapy. Problems often begin when steroid–induced side effects take their toll on a patient, especially in elderly adults.
Read ArticleRheumNow Week in Review - 19 May 2016
Dr. Jack Cush reviews this week's news and research highlights from RheumNow.com.
Read ArticleGWAS Reveals Shared Susceptibility Locus Between RA and SLE
While the phenotypes of RA and SLE are quite different, genome-wide association studies (GWAS) performed in the past have shown a genetic overlap between both.
Read ArticleNetrin-1 May Promote Lung Fibrosis in Scleroderma
Mechanisms underlying the pulmonary fibrosis of systemic sclerosis are poorly understood, yet are the focus of both research and new drug development.
Read ArticleVasculitis Associated with Biologic Use
The widespread use of existing biologics has sometimes been associated with the paradoxical development of biologic-induced autoimmune phenomena, including vasculitis. A recent review of more than 200 vasculitis cases associated with biologic use has profiled the range of these unsual and rare events.
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Scleroderma Digital Ulcers Fail to Respond to Endothelin Antagonist
Khanna and coworkers have published the results of the DUAL-1 and DUAL-2 clinical trials (sponsored by Actelion Pharmaceuticals) testing the efficacy macitentan in reducing the number of new digital ulcers in patients with systemic sclerosis.
Read ArticlefaSScinate Study Shows Tocilizumab to be Effective in Systemic Sclerosis
The results of the faSScinate trial were published in Lancet showing that treatment with Actemra (tocilizumab) resulted in a reduction in skin thickness and an improvement in lung function in patients with systemic sclerosis (SSc).
Read ArticlePoor Outcomes for Dermato/Polymyositis Admitted to ICU
Idiopathic inflammatory myopathies (IIMs) may be complicated with life-threatening conditions requiring intensive care unit (ICU) admission. The outcomes of such complications may be dire, but there are few series addressing the outcomes of those admitted to the ICU.
Read ArticleCan Rituximab Change the Course of Interstitial Lung Disease?
Like other extraarticular manifestations, rheumatoid (RA) or connective tissue disease (CTD) related interstitial lung disease (ILD) is difficult to identify early and equally challenging to treat.
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Posterior Reversible Encephalopathy in Lupus
Posterior reversible encephalopathy syndrome (PRES) is a rare neurological disorder with many associations or causative factors that rarely includes autoimmune disorders and lupus.
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CV Events Strike Early in Lupus
Patients with systemic lupus erythematosus are at risk of cardiovascular events early in the course of disease -- and even before their lupus is diagnosed, an international study found.
Read ArticleRheumNow Week in Review - 15 April 2016
Video recap of highlights from this week at RheumNow.com.
Read ArticleBiosimilar Reports - April 2016
Major advances in biosimilars have occurred in the last three months, beginning with the FDA Arthritis Advisory Committee voting 21-3 to approve Celltrion’s Inflectra (CT-P13) and ending with the recent approval of Inflectra (generically referred to as infliximab dyyb).
Read ArticleLupus Patients Genomically Stratified to Explain Treatment Responses
Systemic lupus is a clinically heterogeneous disorder, unified by requisite clinical features and exuberant humoral response to unknown triggers. While the diagnosis is easy, the disease course and management can be complicated and challenging.
Read ArticleRheumNow Week in Review - 8 April 2016
Dr. Jack Cush reviews the rheumatology highlights from the news, media, and journals from this past week:
Read ArticleAltering the Microbiome May Benefit Lupus Patients
Lopez and colleagues from Spain have studied the gut microbiome of l
Read ArticleChoosing ANA Tests Wisely - Education Fosters Smarter Use
It is estimated that 21% of laboratory tests are requested inappropriately. Researchers have explored the impact of educational programs for rheumatologists working at three rheumatology departments in secondary and tertiary care centers in The Netherlands.
Read ArticleEUSTAR Analysis Yields Predictors of Skin Improvement in Diffuse Systemic Sclerosis
Systemic sclerosis is one of the most challenging of rheumatic diseases, often complicated by significant morbidity and leads to irreversible disability in many cases.
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