Skip to main content

Chronic Digital Ulcers in Systemic Sclerosis Portends More Complications

Nov 29, 2015 11:30 pm

A prospective, international observational study of systemic sclerosis patients enrolled in the Digital Ulcers Outcome (DUO) Registry: Patients were required to have ≥3 follow-up visits over at least a 2 year observation period between 2008-2013. Incident digital ulcerations (DU) were identified along with their associated complications.

From the 1459 patients enrolled, patients could be categorized as having either: 1) no-DU (33.2%); 2) episodic (9.4%); 3) recurrent (46.2%); and 4) chronic ( 11.2%) DU. Limited SS was seen in 51-59% of groups 1-3, but only 44% of group 4 - chronic DU patients. Thus those with chronic DU were more likely to have diffuse than limited SS (46 vs 44%).

The highest rate of incident complications was seen in the chronic DU group. Pain medication (72%), hospitalization (52%), infection (61%) and amputatoin 16%) were greatest in the chronic DU group. Risk factors associated with incident complications included gastrointestinal manifestations (OR 3.73, p=0.03) and previous soft tissue infection (OR 5.86, p=0.01).

These categories may be instrumental in identifying which SS patients may need more aggressive treatment interventions.

Disclosures
The author has no conflicts of interest to disclose related to this subject

Add new comment

If you are a health practitioner, you may to comment.

Due to the nature of these comment forums, only health practitioners are allowed to comment at this time.

×