High Drug Discontinuations and Nonadherence in Fibromyalgia Save
Compliance and adherence was shown to be quite poor in fibromyalgia (FM) patients, with high rates of drug discontinuation and greater than 60% demonstrated low adherence.
Using claims data from a large, Israeli, health maintenance organization 3922 FM were assessed from 2008 through 2011; specifically looking at the following agents over a 12 month period: pregabalin, antidepressants [selective serotonin reuptake inhibitor (SSRI), serotonin/norepinephrine reuptake inhibitor (SNRI)], and tricyclic antidepressants (TCA).
The proportion of days covered (PDC) was used as a measure of drug adherence. A PDC
Of the 56.1% issued a qualifying prescription, 45.0% were dispensed at least 1 medication in the year following diagnosis, and only 28.8% had prescriptions filled twice within the first year from diagnosis.
The 1-year drug discontinuation was highest for TCA (91.0%) and lowest for SSRI/SNRI antidepressants (73.7%).
Over half of the patients (60.5%) had fewer than 20% of the days covered by any medication during the year and only 9.3% were very adherent (PDC ≥ 80%).
FM management may be confounded and complicated by high drug discontinuations and low adherence.