Pfizer Features Xeljanz Presentations at ACR 2016 Save

At this years 2016 ACR/ARHP Annual Meeting Pfizer will presen 20 abstracts, mostly centering around its JAK inhibitor tofacitinib (Xeljanz). They will also present the results of their Phase 3 OPAL studies of tofacitinib in patients with psoriatic arthritis.

Their listing of presentations includes:

XELJANZ in RA

Oral Presentations

• Major Adverse Cardiovascular Events: Risk Factors in Patients with RA Treated with Tofacitinib [#3024, Session: Rheumatoid Arthritis – Small Molecules, Biologics and Gene Therapy III: Small Molecules and Early Intervention, Nov. 15, 2016, 2:30-4p.m.]
• Inflammation Detected with Modern Sensitive MRI Analysis Demonstrates that Therapeutic Response as Early as One Month Predicts 12-Month Radiographic Progression: Data from a Study Using Tofacitinib and Methotrexate in
• Early RA [#3090, Session: Rheumatoid Arthritis – Small Molecules, Biologics and Gene Therapy IV: Biomarkers, Nov. 15, 2016, 4:30-6p.m.]

Poster Presentations

• Magnitude and Duration of Early Response with Tofacitinib: Post-Hoc Analysis of Two Phase 3, Placebo-Controlled Studies [#1595, Session: Rheumatoid Arthritis – Small Molecules, Biologics and Gene Therapy - Poster II, Nov. 14, 2016, 9-11a.m.]
• Persistence of Tofacitinib in the Treatment of Rheumatoid Arthritis in Open-Label, Long-Term Extension Studies up to 8 Years [#1602, Session: Rheumatoid Arthritis – Small Molecules, Biologics and Gene Therapy - Poster II, Nov. 14, 2016, 9-11a.m.]
• Efficacy of Tofacitinib in Patients who are Inadequate Responders to Disease-Modifying Antirheumatic Drugs According to Early Versus Late Duration of Rheumatoid Arthritis: Post-Hoc Analysis of Data from Phase 3 trials [#1609, Session: Rheumatoid Arthritis – Small Molecules, Biologics and Gene Therapy - Poster II, Nov. 14, 2016, 9-11a.m.]
• Tofacitinib: Treatment Outcomes in Seropositive Versus Seronegative Patients in a Phase 3 RA Population [#1643, Session: Rheumatoid Arthritis – Small Molecules, Biologics and Gene Therapy - Poster II, Nov. 14, 2016, 9-11a.m.]
• Discontinuation of Methotrexate or Glucocorticoids in Patients with Rheumatoid Arthritis Treated with Tofacitinib: Clinical Efficacy Data from Long-Term Extension Studies [#1646, Session: Rheumatoid Arthritis – Small Molecules,Biologics and Gene Therapy - Poster II, Nov. 14, 2016, 9-11a.m.]
• Tofacitinib, an Oral Janus Kinase Inhibitor, in the Treatment of Rheumatoid Arthritis: Safety and Efficacy in Open-Label, Long-Term Extension Studies over 8 Years [#1647, Session: Rheumatoid Arthritis – Small Molecules, Biologics and Gene Therapy - Poster II, Nov. 14, 2016, 9-11a.m.]
• Long-Term Clinical, Radiographic and Patient-Reported Outcomes Based on RAPID3 Responses with Tofacitinib at 6 Months [#1648, Session: Rheumatoid Arthritis – Small Molecules, Biologics and Gene Therapy - Poster II, Nov. 14, 2016, 9-11a.m.]
• Evaluation of Disease Activity in Patients with Rheumatoid Arthritis Treated with Tofacitinib by RAPID3: An Analysis of Data from 6 Phase 3 Studies [#1600, Session: Rheumatoid Arthritis – Small Molecules, Biologics and Gene Therapy - Poster II, Nov. 14, 2016, 9-11a.m.]
• Lack of Early Change in Disease Activity Score Predicts the Likelihood of Achieving Low Disease Activity at Month 6: Tofacitinib Monotherapy versus Methotrexate in Methotrexate-Naïve Patients with Rheumatoid Arthritis [#1608, Session: Rheumatoid Arthritis – Small Molecules, Biologics and Gene Therapy - Poster II, Nov. 14, 2016, 9-11a.m.]
• Real World Results from a Post-Approval Safety Surveillance of Tofacitinib (Xeljanz): Over 3 Year Results from an Ongoing US-Based Rheumatoid Arthritis Registry [#2595, Session: Rheumatoid Arthritis – Small Molecules, Biologics and Gene Therapy - Poster III, Nov. 15, 2016, 9-11a.m.]
• Effect of Glucocorticoids on Clinical and Radiographic Efficacy Outcomes in Methotrexate-Naïve Patients with RA Receiving Tofacitinib or Methotrexate Monotherapy: Analysis of Data from a Phase 3 Trial [#2606, Session: Rheumatoid Arthritis – Small Molecules, Biologics and Gene Therapy - Poster III, Nov. 15, 2016, 9-11a.m.]
• The Effectiveness of Zoster Vaccine in RA Patients Subsequently Treated up to 19 Months with Tofacitinib [#2609, Session: Rheumatoid Arthritis – Small Molecules, Biologics and Gene Therapy - Poster III, Nov. 15, 2016, 9-11a.m.]

XELJANZ Investigational Research Areas

Oral Presentations

• Treatment with Tofacitinib is Associated with Clinically Meaningful Reductions in Axial MRI Inflammation in Patients with Ankylosing Spondylitis [#1044, Session: Spondylarthropathies and Psoriatic Arthritis – Clinical Aspects and Treatment II: Axial Spondyloarthritis – Treatment, Nov. 13, 2016, 4:30-6p.m.]
• Efficacy and Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, or Adalimumab in Patients With Active Psoriatic Arthritis and An Inadequate Response to Conventional Synthetic DMARDs: A Randomized, Placebo controlled, Phase 3 Trial [#2983, Session: Plenary Session III: Discovery 2016, Nov. 15, 2016, 11a.m.-12:30p.m.]

Poster Presentations

• Efficacy and Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Patients with Active Psoriatic Arthritis and an Inadequate Response to Tumor Necrosis Factor Inhibitors: OPAL Beyond, a Randomized, Double Blind, Placebo-Controlled, Phase 3 Trial [#10L, Late-breaking Abstract Poster Session, Nov. 13, 2016, 9-11a.m.]
• Pharmacokinetics, safety, and tolerability of tofacitinib in pediatric patients from two to less than eighteen years of age with juvenile idiopathic arthritis [#388, Session: Pediatric Rheumatology – Clinical and Therapeutic Aspects - Poster I: Juvenile Idiopathic Arthritis, Uveitis, Nov. 13, 2016, 9-11a.m.]

Additional Pfizer-Sponsored Abstracts

Poster Presentations

• Understanding the Importance of a Patient’s Role in the Management of RA: Physician- and Patient-Based Survey [#81, Session: Health Services Research - Poster I, Nov. 13, 2016, 9-11a.m.]
• Treatment Patterns, Unmet Need, and Impact of Psoriatic Arthritis on Patient-Reported Outcomes in the United States [#2729, Session: Spondylarthropathies and Psoriatic Arthritis – Clinical Aspects and Treatment - Poster III, Nov. 15, 2016, 9-11a.m.]