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Elevated Uric Acid Is Associated With New‐Onset Atrial Fibrillation

Jan 16, 2023 5:21 pm

A Longitudinal Swedish study has shown that elevated serum uric acid (SUA) levels has cardiovascular implications and may predict the development of atrial fibrillation (AFib). 

Adults (30 to 60 years) in the Swedish AMORIS (Apolipoprotein‐Mortality Risk) study, initially without any CV disease.  After a mean follow‐up of 25.9 years, 46 516 incident AFib cases occurred in a total cohort of 339,604 persons. Those in the upper 3 quartiles of SUA were found to have increased risk of AF, with significantly rising adjusted hazard ratios of 1.09, 1.19, and 1.45 ; suggesting a dose response related risk.

The results were unaffected by hypertension, diabetes, heart failure, or coronary heart disease.

Increased uric acid increased risk of AF, in those with cardiovascular disease and cardiovascular risk factors and also among those without.


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The author has no conflicts of interest to disclose related to this subject