Hospital Mortality in Dermatomyositis Save
A cohort study shows that hospitalized patients with dermatomyositis have higher in-hospital mortality in the presence of active rash, interstitial lung disease, and elevated neutrophil to lymphocyte ratio at admission.
Dermatomyositis (DM) has significiant morbidity and mortality risks; but is this altered with DM patients who are hospitalized?
This single center cohort study included adults with DM admitted for any cause at a single tertiary referral center between 2013 and 2024. A total of 153 DM patients (113 females; mean 56.5 yrs of age) were included. Death during hospitalization was seen in 16 (10.5%). In-hospital mortality was significantly increased with:
- Active rash (81% vs 34%) (OR 12.13)
- ILD (87% vs 42% (OR 6.43)
- Elevated NLR (mean 12.5 vs 4.9) (OR per 1-unit increase, 1.29)
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Outcomes were not associated with myositis subtypes, myositis-specific autoantibody status or use of intravenous immunoglobulin.
Recognizing these high-risk features may guide inpatient management and support future risk stratification strategies.
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Disclosures
The author has no conflicts of interest to disclose related to this subject
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