Recent News
Read ArticleDr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. This week with a focus on fingers and better prescriptive follow through.
Dactylitis is seen in 50% of PsA patients. Dactylitis is frequently associated with more severe PsA phenotype, often representing the initial feature of the disease. Many agents are effective but no b/tsDMARD is distinguished as being superior in dactylitis.… https://t.co/NKOXReiZYd https://t.co/Ake2fixZ40
Dr. John Cush @RheumNow ( View Tweet)
"Vanishing Fingers" Acro-osteolysis in a patient with Scleroderma and renal failure and bilateral hand pain. Causes of AO include Scleroderma, PsA, hypertrophic osteoarthropathy, skeletal dysplasias, frostbite, Hyperparathyroidism, genetic disorders https://t.co/UwXcw3r6LD https://t.co/bnGiY0i0ot
Links:
Dr. John Cush @RheumNow ( View Tweet)
Difficult to treat RA Approach
https://t.co/2rmlv0kspP https://t.co/6yb5xj8jrn
Dr. John Cush @RheumNow ( View Tweet)
RA Experts (Drs. Wells, Troum, Wright, Broadwell) discuss dose response differences in treating RA. Watch this video sponsored by Genentech! https://t.co/NUVgNVuMng https://t.co/oILdbPO7Bk
Dr. John Cush @RheumNow ( View Tweet)
Urticarial Vasculitis Overview
Urticarial vasculitis is rare and the causes often go undiagnosed. A Medscape recent overview highlights key features in the diagnosis and management of this rare disorder.
https://t.co/ATUUcV7MYP https://t.co/3brB4j7nlb
Dr. John Cush @RheumNow ( View Tweet)
Norwegian Registry study compared risk of stroke in 2750 RA vs 158 879 w/o RA pts. 7.3 vs 5% (HR 1.36; 1.13, 1.62). RA pts with atrial fibrillation was also elevated (HR 1.25; 1.05, 1.5). RA pts less likely to Rx w/ oral anticoagulants (adj OR 0.88) than non-RA… https://t.co/s20wTKafR8 https://t.co/FPxc5VP4Xh
Dr. John Cush @RheumNow ( View Tweet)
Study of 4821 pts (age 52 yrs) undergoig EGD - H. pylori infx seen in 2262, w/ long-lasting H Pylori (LLHp) infx in 1043 (21.6%). 6.3% dx w/ aCVD & 4.3% w/ RA. LLHp infection incr risk of aCVS (HR 1.57) & RA (HR 2.63) In RA, LLHp up risk for aCVD (7.89) https://t.co/FNOsEHKVIf https://t.co/dSeJuuuUMQ
Dr. John Cush @RheumNow ( View Tweet)
CAR-T Like Effects with Bispecific Teclistamab
MedPage Today
A new chapter may have begun in the exciting story of "immune reset" therapy for difficult-to-treat autoimmune diseases, with a patient with severe refractory lupus obtaining drug-free remission after treatment with an antibody product normally used in multiple myeloma.
Read Article
Does Rheumatoid Factor Influence Anti-TNF Responses in RA?
Smolen and colleagues have published a subanalysis of the EXXELERATE study that showed while certolizumab pegol [CZP] concentrations and efficacy was unaffected by high titers of rheumatoid factor (RF), patients treated with adalimumab had a blunted response in the face of high RF titers.
Read Article
Is it possible that Helicobacter pylori (Gm neg) can exacerbate or cause RA? Infx of gastric epithelial cell line w/ H. pylori upregulated the expression of PAD4 and increased PAD4 activity, leading to Helicobacter pylori-induced citrullination? https://t.co/QeE3SmWLLp https://t.co/ZG2tYmdJNx
Dr. John Cush @RheumNow ( View Tweet)
Singapore study of Autoimmune (AIRD) risk w/ COVID infx compared 104 179 DELTA + pts vs 666 575 PCR neg controls (~80+% Vax) & 375 903 Omicron+ vs 619 379 controls (~75% boosted). Found no signif incr risk of AIRD w/ COVID infx. https://t.co/gXzWdotzvL https://t.co/UsQpwgsyTD
Dr. John Cush @RheumNow ( View Tweet)
Scleroderma Raynaud's May Worsen in Summer
Episodes of Raynaud's phenomenon, a common feature of systemic sclerosis (SSc, also known as scleroderma), were more severe not only at low temperatures, as one would expect, but also during summertime heat, a multinational study… https://t.co/w7rKuxgtyD https://t.co/G0gO8PffkE
Dr. John Cush @RheumNow ( View Tweet)
Immunomodulatory Prevention of Uveitis Relapse in Behçet's
The results of a randomised, open-label, head-to-head trial shows that adalimumab was superior to ciclosporin in preventing uveitis relapses in patients with severe Behçet's disease.
https://t.co/12fpuIZFmA https://t.co/iDJJq29JMA
Dr. John Cush @RheumNow ( View Tweet)
EMA Updated overview of leflunomide (Arava) https://t.co/rr0YIuf6uR https://t.co/oR02J2VouO
Dr. John Cush @RheumNow ( View Tweet)
Study of 4370 RA pts (26534 PYs) saw 362 MACE (CV) events. RA activity & inflammatory markers assoc w/ MACE risk in bDMARD non-users (not those on bDMARDs). 515 bDMARD vs 3855 non-users (n=3855). Each DAS28-CRP unit incr MACE risk (HR 1.21)https://t.co/lRaHxTHzqe https://t.co/usEiJctVYk
Dr. John Cush @RheumNow ( View Tweet)
Urticarial Vasculitis Overview
Urticarial vasculitis is rare and the causes often go undiagnosed. A Medscape recent overview highlights key features in the diagnosis and management of this rare disorder.
Read Article
Claims analysis, shows <0.5% of IBD or RA pts developed an invasive fungal infx within 1 year of TNF therapy initiation (. Histoplasmosis was the most common
IBD = 3.3 IFI/100PY
RA = 2.8 IFF/100PY https://t.co/ER9YCxecJT https://t.co/T0UNgB4h6R
Dr. John Cush @RheumNow ( View Tweet)
Prospective Nurses' Health Study (n 204,175) included 212 w/ incident SLE; ultraprocessed food intake was assoc w/ >50% increased SLE risk & doubled risk for anti-dsDNA Abs. Sugar-/artificially sweetened drinks assoc w/ lupus risk (HR 1.45) https://t.co/jesfsgNvUY https://t.co/KQupBkEcKg
Dr. John Cush @RheumNow ( View Tweet)
Metanalysis of Social determinants of health and lupus nephritis (31 studies) showed poor LN outcomes were 1.47-fold higher w/ any adverse SDoH. Also multiplicative impact of having two or more adverse SDoH on LN outcomes. https://t.co/4oEuAEgBx1 https://t.co/OkeRzrCXzQ
Dr. John Cush @RheumNow ( View Tweet)
Good Clinical Practice Recommendations on Glucocorticoid Withdrawal and Adrenal Insufficiency
The European Society of Endocrinology and Endocrine Society have jointly published a clinical guideline on the diagnosis and treatment of glucocorticoid-induced adrenal insufficiency,… https://t.co/hGg8s2ml3c https://t.co/HMbqhn8jhw
Dr. John Cush @RheumNow ( View Tweet)
From the blog
Podcasts
Linger On The Fingers (9.6.2024)
Earlier treatment with biologics to reduce the risk of organ damage-
Running With Data (8.30.2024)
-
All In The Family (8.23.2024)
Therapeutic Updates
Earlier treatment with biologics to reduce the risk of organ damage in systemic lupus erythematosus (SLE)
Sponsored by GSK US Medical Affairs
Learn about the importance of reducing organ damage and corticosteroid-associated toxicity in SLE, and how biologics may help to change the course of
the disease by targeting its underlying mechanisms.
Read Post
Are your patients with moderate to severe RA getting the appropriate dose?
Sponsored by Genentech, Inc
Hear experts’ roundtable discussion with Dr. Alvin Wells, Dr. Orrin Troum, Dr. Grace Wright, and Dr. Aaron Broadwell in this video sponsored by Genentech.
Read Post
