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Secondary Sjogren’s Ups Rheumatoid Arthritis Severity
A Swiss observational study has shown that rheumatoid arthritis (RA) patients with concomitant Sjögren’s disease (SjD) are more likely to have a severe RA phenotype, and be less responsive to treatment.
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Naysayers & Disrupters (3.22.2024)
Dr. Jack Cush reviews the news and journal reports from the past week - including a few contrary reports on infection, seropositivity and plasmapheresis.
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CV Risk Early with Rheumatic Disease Diagnosis
A Finnish populaton study shows that the temporal relationship between cardiovascular (CV) comorbidities in rheumatic diseases (RMD) is seen early after the RMD diagnosis.
Research on SGLT2 inhibitors in #gout is needed. They have been shown to reduce uric acid & gout flares, and may be uricosuric or be antiinflammatory. Also decreased incident gout (by half) among at-risk patients with type 2 diabetes (HR 0.54) https://t.co/ZEmhwqyDOv https://t.co/58YKD6pFyt
Dr. John Cush RheumNow ( View Tweet)
Marketing research suggests that the global rheumatoid arthritis drug market was valued at USD $17.87 billion in 2023 and is projected to reach around USD 25.67 billion by 2032 https://t.co/w4ErmjtFNV https://t.co/5bmcVJ7zh4
Dr. John Cush RheumNow ( View Tweet)
Marketing research estimates there were 1,389,116 prevalent cases of Ankylosing Spondylitis in 2017 https://t.co/bn4QHBNxEd https://t.co/BN1aNvgebS
Dr. John Cush RheumNow ( View Tweet)
Chronic MSK Pain and Earlier Retirement
Frequent musculoskeletal pain is linked with an increased risk of exiting work and retiring earlier, according to a new study published in the journal PLOS ONE.
https://t.co/wRKYjmtaAX https://t.co/n5HzbDNmGz
Dr. John Cush RheumNow ( View Tweet)
post hoc of the PEXIVAS study 704 participants w/ severe ANCA vasculitis: 92% achieved remission & 23% had relapses (rate 10.3/100PYs)-- Neither plasma exchange nor glucocorticoid tapering regimen impacted relapse risk. https://t.co/LKaqptWbxZ https://t.co/nOvE6BqYOl
Dr. John Cush RheumNow ( View Tweet)
Infection and Rituximab-linked Immunoglobulin Deficiency
A recent cohort analysis suggests that RTX-induced Ig deficiency was not associated with an increased risk of severe infection in IMID patients.
https://t.co/bNmYyYi2Vs https://t.co/MXKRbrrIJS
Dr. John Cush RheumNow ( View Tweet)
Series of Chronic Cutaneous Lupus responding to anifrolumab. 6 pts (4 DLE, 2 CCLE) betw 37-66 yrs old w/ Dz duration 10.5 yrs, 4 w/ SLE, all refractory to multiple therapies Rx w/ ANIF w/ Skin benefit. 1 developed herpes, 1 had worsening of nephritis https://t.co/6imLq3TDMu https://t.co/BMoIQhRtYs
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Dr. John Cush RheumNow ( View Tweet)
Biden signs executive order on womens health research ($200 million to NIH interdisc. women res), focus on:
- integrate Women’s Health Across Federal Research prgs
- fund Research on Women’s Midlife Health
- double funding Office Womens Health Research
https://t.co/28u9lLdboL https://t.co/sld0BxsSB8
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Dr. John Cush RheumNow ( View Tweet)
Join our experts, Drs Liebowitz and Mehta, as they provide insights on the differential diagnosis and management concepts in autoinflammatory diseases. Sponsored by Novartis Pharmaceutical Corporation.
https://t.co/doSRuW0nLq https://t.co/w65jVHienh
Dr. John Cush RheumNow ( View Tweet)
4873 gout pts w/ High SUA renally typed: UA overproduct. (ROA 9%); underexcreter (RUE 61%); combined (23%) or normal (7%)
ROL: older, lower SUA, tophi & DM
RUE: lower BMI, No DM
Combined: younger, HighBMI/SUA/eGFR & smoking
Normal: older, Low SUA/eGFR https://t.co/sfcIoR0YTN https://t.co/ulqP6XyKMa
Dr. John Cush RheumNow ( View Tweet)
Post-COVID POTS? Neurology cohort study of 16 pts - 81%F, mean age 36. Common Sxs:
- Palpitations & Fatuge in 2/3
- in <1/3: migraines, IBS, Raynaud’s
- Variable tilt test but High autonomic Sxs
No insights on Rx... https://t.co/I7MLjHAUDb https://t.co/hWnfJ9WWPX
Dr. John Cush RheumNow ( View Tweet)
We're gearing up for Tuesday Night Rheumatology all April long. Register today!
Our first TNR takes place 4/2 at 6:30pm ET and will focus on Success in Rheumatoid Arthritis.
https://t.co/FeeOdxOiRQ https://t.co/FNoCi6goQS
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Dr. John Cush RheumNow ( View Tweet)
FDA grants orphan drug designation to CAR T-cell therapy for systemic sclerosis https://t.co/KZKSy2sbNk https://t.co/5abz8MeYGK
Dr. John Cush RheumNow ( View Tweet)
Expert Panel Guidance on Managing Psoriatic Arthritis and Comorbidities
An expert panel has published their consensus guidelines for the management of psoriatic arthritis (PsA) and it's comorbidities in the journal Rheumatology.
https://t.co/pZjnW4dPxj https://t.co/Si9Gl3WgUx
Dr. John Cush RheumNow ( View Tweet)
Chronic MSK Pain and Earlier Retirement
Frequent musculoskeletal pain is linked with an increased risk of exiting work and retiring earlier, according to a new study published in the journal PLOS ONE.
https://t.co/f2skRvd6Dl https://t.co/K8bJjcGOSF
Dr. John Cush RheumNow ( View Tweet)
1st trimester exposure to Plaquenil is not assoc. w/ risk of congential malformations (MCM). Swedish registry data on 1007 births (453 exposed) & 2500 births (144 exposed) in SLE & RA, respectively. MCM risks in SLE &RA were 3.4-5.7%, no diff betw groups https://t.co/lzbd7AQqy1 https://t.co/AsFYYBQQtm
Dr. John Cush RheumNow ( View Tweet)
post hoc of the PEXIVAS study 704 participants w/ severe ANCA vasculitis: 92% achieved remission & 23% had relapses (rate 10.3/100PYs)-- Neither plasma exchange nor glucocorticoid tapering regimen impacted relapse risk. https://t.co/UN6RujwZKc https://t.co/MsXKPwp9km
Dr. John Cush RheumNow ( View Tweet)