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Tic-Borne Disorders Causing Chronic Arthritis?
Findings from a population based cross-sectional study suggests that while up to 20% of patients have antibodies to tick-borne exposures, only a minority reported musculoskeletal symptoms.
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2023 EULAR Non-pharmacological Management of Hip and Knee Osteoarthritis: 2023 update
EULAR has published the 2023 updated recommendations for the optimal non-pharmacological management of hip and knee osteoarthritis (OA).
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Sodium Channels, Carbemazepine and Osteoarthritis Progression
A study published in Nature suggests that therapies affecting sodium channels could be employed to treat osteoarthritis.
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SLE: A Mutated Gene and TLR7 Overexpression
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EurekAlert!
A group of researchers lead by Min Ae Lee-Kirsch from the Department of Pediatrics, Medical Faculty, TUD Dresden University of Technology (Germany), studied four patients from two families who developed symptoms of SLE in the first years of life.
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While NSAID use has been assoc w/ lower risk of cancers (CNS, breast, esophageal, gastric, head & neck, hepatocellular, cholangiocarcinoma, colorectal, endometrial, lung, ovary, prostate, pancreatic); NSAIDs should not be used to prevent cancers https://t.co/YcsU7x7iy0 https://t.co/QJjHqjnuEo
Dr. John Cush RheumNow ( View Tweet)
Retrospective study of 170 #RA on TNFi (Inflx 53%, ADA 28%, CZP 19%). RF, CCP, Drug levels, anti-Drug Abs done.@6 mos HI baseline RF linked to lower drug levels for IFX & ADA; but not CZP. IFX/ADA Hi-RF pts had more dropouts vs CZP (80%/75%/33%, p=0.002) https://t.co/AIgJNkzcWu https://t.co/pQmfmLoFwe
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Hepatitis B Virus Reactivation is possible w/ immunosuppression- most (>10%) w/ w/ Rituximab & stem cell transplants. If HBsAg positive, pts should recv anti-viral prophylaxis; HBsAg− individuals should be evaluated on a case-by-case basis https://t.co/05M28fRXNc https://t.co/38IBMK4gYh
Dr. John Cush RheumNow ( View Tweet)
European ustekinumab (Stelara) biosimilar Uzpruvo® (AVT04) was granted marketing authorisation by European Commission & will be available in July 2024. US FDA approved Wezlana (ustekinumab-auub) in 11/2023. https://t.co/Wv2Z7P5xAu https://t.co/PdGEUpyRU6
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SLE: A Mutated Gene and TLR7 Overexpression
A group of researchers studied four patients from two families who developed symptoms of SLE in the first years of life.
https://t.co/ggr1nMQnh0 https://t.co/c6IoJlgida
Dr. John Cush RheumNow ( View Tweet)
2023 Rheumatology Year in Review
Dr. Jack Cush reviews highlights, advances and hot topics in rheumatology from 2023 and the RheumNow website
https://t.co/5Y9ezzS5zC https://t.co/pqpMR8jDlk
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Real-world data of 5070 RA pts (1816 Rx w/ b/tsDMARDs) showed the use of tsDMARD considerably increased from 2012 to 2021. All b/tsDMARDs pts improved Dz activity & function/ 10 yr effiicacy best for IL6Ri in switch pts and ABA in bNAIVE pts https://t.co/h9j8Pk03if https://t.co/gC7Wloujm0
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Metanlysis of 49 studies, 10 RCTs examined the relationship between RA and non-surgical Rx of periodontitis (NSRT) and in general short term studies show that NSPT benefits RA patients; and DMARD therapy benefits periodontitis https://t.co/HeBA6xtw2O https://t.co/J2QUYVk3gE
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Heritability of Osteoarthritis
A Swedish study examine the genetic contribution to various rheumatic/musculoskeletal diseases (RMDs) and showed that osteoarthritis (OA) had a large heritability compared with other RMDs.
https://t.co/KbQDQ1mB53 https://t.co/opLrlRit2W
Dr. John Cush RheumNow ( View Tweet)
Bidirectional relationship betw Autoimmune disease (AD) & perinatal depression (PND); 1:10 case control study of 1.3 milion pregnancies & 55,299 incident PND found AD preg w/ a 30% (OR 1.3) higher risk of PND & PND had a 30% ^ risk (OR 1.3) of AD https://t.co/zkwIo6liC7 https://t.co/Sy1HPLLeva
Dr. John Cush RheumNow ( View Tweet)
Experience the Future of Rheumatology at RheumNow Live 2024, just two weeks away!
Don't miss out – secure your spot today for an unforgettable journey into the latest advancements and insights.
https://t.co/bbnb97MOHO https://t.co/QXO34ZmP2i
Links:
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QD Clinic - ANA Positivity in RA
Considering an ANA+ Seropositive RA Patient
https://t.co/q0g0JsSWGu https://t.co/nXcEZbbEXG
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Enthesitis, Synovitis, and Tenosynovitis in Psoriatic Arthritis
An ultrasound study suggests that enthesitis is associated with both synovitis and tenosynovitis in patients with Psoriatic arthritis (PsA).
https://t.co/c9z0nsABe0 https://t.co/Ez4i8qCcJ8
Dr. John Cush RheumNow ( View Tweet)
Curcumin therapy for knee osteoarthritis
Curcumin is widely used in traditional Chinese medicine to treat arthritis and is presumed to have analgesic and antiinflammatory effects that may benefit those with osteoarthritis, particularly KOA.
https://t.co/a8JscOOhmz https://t.co/j1htFQkfnD
Dr. John Cush RheumNow ( View Tweet)
Hydroxychloroquine Overview (full read)
History, PK/PD, MOA, Clinical Benefits, dosing, Adverse events covered.
https://t.co/oJcM5ewOBh https://t.co/UaUiH7rpfM
Dr. John Cush RheumNow ( View Tweet)
2023 Rheumatology Year in Review
Check out my top 10 list (in no particular order) of 2023 advances, game-changers, and developments that changed, or will soon change, rheumatologic practices.
https://t.co/UaaAd8pcpM https://t.co/8EIkMeunyZ
Dr. John Cush RheumNow ( View Tweet)