RheumNow Podcast – Rituximab Monitoring (5.31.19) Save
Dr. Jack Cush presents the news and best of rheumatology and medicine from the past week on RheumNow.com
- Korean National Health Insurance data compared the risk of CV events in 39,640 gout pts starting allopurinol or febuxostat. MACE incidence was 1.89 vs 1.84/100PY (HR 1.09; 0.90, 1.32) Thus, no significant difference in CV risk with these agents in Asians https://buff.ly/2EJobhj
- Risk factors for gouty tophi that ulcerate include: glucocorticoid overuse, tophi duration, and the number of tophi. Based on a chinese study of 105 tophaceous patients of whom 33 developed ulcerations https://t.co/rzYTFCb5jk
- 184 juvenile Fibromyalga pts randomized to PBO or duloxetine (30-->60mg/d) for 13wks. Those on duloxetine failed the primary endpoint - mean 24 hr change in Brief Pain Inventory (BPI), but more Cymbalta pts had 30% and 50% BPI reductions https://t.co/EuyCRqKzN7
- Lyrica is FDA approved for FM, Neuopathy & adjunctive Rx for partial-onset seizures; but recently failed to meet primary endpoint in a phase III RCT to prevent primary gen tonic-clonic seizures.- but is continuing to develop it for pediatric epilepsy. https://t.co/T9T0Kv1wkP
- Japanese study 198 systemic sclerosis pts finds that higher skin thickness scores (modified Rodnan Skin Scores; mRSS) associated with higher risk of interstitial lung disease (P < 0.05), restrictive LDz(P < 0.01), and diffusion impairment (P < 0.05) https://t.co/PY4n6N5Ub9
- Metanalysis suggests leflunomide in psoriatic disease is better at treating arthritis (PsA PsARC 77%) than skin disease (psoriasis PASI50 48% & PASI75 25%). Adverse events in 38% and 15% drop out rate. https://t.co/BIPNtYE6Tr
- Large UK study shows central adiposity (waist circumference) signify increases risk of psoriasis and rheumatoid arthritis; not PsA. a cross-sectional study of the UK Biobank https://t.co/eKDpUodSR1
- Prospective study of 4796 pts in Osteoarthritis Initiative shows metformin use in obese pts (BMI >30) was Assoc with significantly less medial cartilage loss (0.71% vs. 1.57%/yr) & a trend towards fewer knee replacements over 6 yrs (OR 0.30, p = 0.11) https://t.co/LD0jFWtSLM
- Biologic Retention in Ankylosing Spondylitis Patients
- The Cost of Physician Burnout
- Predictors of Serious Infections with Rituximab
ADD THE FIRST COMMENT
Disclosures
The author has received compensation as an advisor or consultant on this subject
If you are a health practitioner, you may Login/Register to comment.
Due to the nature of these comment forums, only health practitioners are allowed to comment at this time.