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Infection or Disease Flare: What Tools Can Help Differentiate?
Differentiation between a flare of disease and infection in patients with autoinflammatory (AI) conditions, where fever is the hallmark, can be extremely difficult. Few studies have evaluated potential differentiators; and having such tools would meet a huge unmet need.
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Opening Day Report
The opening of ACR2 Convergence was a hit for all who signed up and viewed in. The day included the presidential address by outgoing president Dr. David Karp (UT Southwestern) and a keynote talk and interview with Dr. Seema Yasmin (Stanford).
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AxSpA: Geographic Prevalence Association with HLA-B27: Dr. Rachel Tate ( @uptoTate )
Dr. Rachel Tate discusses abstract #0368 presented at the #ACR21 annual meeting.
https://t.co/CnIjlWuKjZ https://t.co/vytIdK9CCo
Links:
Dr. John Cush RheumNow ( View Tweet)
Knowledge Bowl at #ACR21
⭐️In a suspected PAN case, you order a peripheral smear to look for this potential etiology,
➡️Hairy cells
@RheumNow
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Dr Stewart @TonyMerriman2 report in 16,000 patients that repeat serum urate testing not superior to single measure in predicting incident gout over 9 years. Makes sense in general, maybe different in those with medication changes etc? Abstr#1449 #ACR21 @RheumNow https://t.co/69NofMNuB8
Richard Conway RichardPAConway ( View Tweet)
Guselkumab treatment of PsA improved Hgb levels and ⬇️ incidence of anemia
⭐️Anemia resolution associated with improved clinical status
#ACR21
#ACRBest
Abs#1331
@RheumNow
https://t.co/nbG7DpMDaR https://t.co/rxWsVfNqed
Robert B Chao, MD doctorRBC ( View Tweet)
Knowledge Bowl at #ACR21
⭐️Which HLA allele confers an increased risk for anterior uveitis and inflammatory sacroillitis?
➡️HLA-B27
@RheumNow
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Knowledge Bowl at #ACR21
⭐️This HLA allele can be seen in a certain vasculitis where panuveitis is a possibility and has a venulitis predilection
➡️HLA B51
@RheumNow
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Peripheral and axSpA pts with low Vitamin D levels (<30) had worse disease activity and functional impairment (BASDAI, ASDAS, BASFI) compared to pts with normal Vit D levels.
Abs#1316
#ACR21 @RheumNow
https://t.co/ulIqOAnWtp https://t.co/aMQaTpduJK
Robert B Chao, MD doctorRBC ( View Tweet)
#ACR21 Abs#1225: B/L Extracell Matrix Biomarkers predict ABA response in MTX-naive, +ACPA early RA
⭐️ECM biomarkers predict SDAI remission or DAS28 w ABA+MTX vs PBO+MTX.
⭐️⬆️CTX1 biomarker predicts efficacy endpts for ABA+MTX
https://t.co/7wHQefb5D4 @Rheumnow
Links:
Eric Dein ericdeinmd ( View Tweet)
#ACR21 #Abstr1011 Can we differentiate NEMO-deleted exon 5 autoinflammatory syndrome (NEMO-NDAS) vs CANDLE? Bioinformatics to mask the IKBKG pseudogene is promising and identified IL-6, 8,18, IFN-I and TNF-induced cell death as future targets @RheumNow https://t.co/tR2PNymMVn https://t.co/yCKHQx6R3E
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Abst 0789
Baker & colleagues examined adipokine levels in association with disease activity in RA patients
- Patients with high levels of adipokines less likely to achieve low disease activity & remission
- These patients more likely to escalate to b/tsDMARDs
#ACR21 @RheumNow https://t.co/1xlO4W9q9v
Akhil Sood MD AkhilSoodMD ( View Tweet)
#ACR21 #pedsrheum
juvenile localized scleroderma
Polypositive profile
3 or more autos correlated with more severe skin score, more activity https://t.co/vVXV4jjLvG
Dr. Laura Lewandowski LauraLewMad11 ( View Tweet)
TOFA Post hoc analysis on 2000pts:
⬆️ Paraoxonase PON1 activity associated w/
⬇ risk of malignancies (not NMSC) in RA pts treated w/ TOFA, Adj on RA duration, age, and smoking.
A promising biomarker! #Abst980 @RheumNow #ACR21 https://t.co/fOILnAyDN9
Aurelie Najm AurelieRheumo ( View Tweet)
Awesome presentation today from Dr. Cristina Ruiz-Romero on lipidomic profiles in RA vs PsA. Using mass spectrometry, found differences in both synovial bx and fluid. Potentially useful lipid markers, more studies to follow.
#ACR21 #ACRBest Abst#0946 @RheumNow https://t.co/KmWCPKijSx
Pedro Castillo _Castillo_Pedro ( View Tweet)
Getting closer to personalised medicine in AS, ECM-mediated biomarkers may help predict response to Adalimumab in AS. The biomarkers C1M, C6M and
PRO-C4 were lower in responders to adalimumab treatment after 24 weeks @RheumNow #ACR21 Abst#0915 https://t.co/K2YxPvUAwu https://t.co/w9kcBSFeG9
Dr. Antoni Chan synovialjoints ( View Tweet)
Soluble urinary ALCAM previously shown as potential biomarker for LN. Further study showing urinary ALCAM trended with changes in renal-SLEDAI and UPCr.
#ACR21 Abst#3053 @RheumNow https://t.co/IqVJej7yda
Links:
Pedro Castillo _Castillo_Pedro ( View Tweet)
Abst#0788 #ACR21. Forgot to measure vitamin D?
▶️ Red cell distribution width (RDW) inversely correlates w vit D 25(OH) levels prior to MTX
⭐️ RDW ⬆️ after starting MTX, no longer correlates
https://t.co/b5EPDmGE18 @Rheumnow https://t.co/cNN14ErOmF
Links:
Eric Dein ericdeinmd ( View Tweet)
#ACR21 Abst#0449:
Ever wish you had a tool to help you predict which PsA pts will progress to radiographic damage?
➡️Proteomic approaches identified 103 candidate biomarker peptides related to 69 proteins that can potentially do so!
@Rheumnow @uptoTate
https://t.co/uUsZlBLTWC
Links:
Meral K. El Ramahi, MD MeralElRamahiMD ( View Tweet)
Are we getting closer to personalised medicine in #psoriaticarthritis Predicting progressors vs non-progressors using proteomics identified 103 candidate biomarker peptides that will discriminate the two groups @RheumNow #ACR21 #ACRBest Abst#0449 https://t.co/obDXTz3i5N
Dr. Antoni Chan synovialjoints ( View Tweet)
