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CBC Hidden Pearls
CBC…it’s easy as 123! The complete blood count (aka, CBC) is the most routine, but indispensable, of all medical assessments.
Read ArticleLupus Flares After Renal Transplant
Whether lupus activity is ameliorated by end-stage renal disease (ESRD) or transplantation has been debated.
Read ArticleHigh 14-3-3η Levels Have Predictive Value in Early Inflammatory Arthritis
14-3-3η is a new serum assay that has utility in diagnosing and treating patients with rheumatoid arthritis (RA) and early inflammatory arthritis (EIA).
Read ArticleANA Negative Lupus Nephritis - Does it Exist?
A recent report from the Mayo Clinic describes a 49 year-old patient with lupus nephritis who presented with new-onset hypertension, edema, arthritis, serositis and leukocytoclastic vasculitis, and who later developed glomerulonephritis and nephrotic syndrome.
Read ArticleOminous Outcomes for Lupus Nephritis
Hanly and coworkers have reported the results of a large lupus cohort study involving 1827 patients. SLE patients were enrolled early in their disease (0.5 years) and were followed for a mean of 4.6 years.
Read ArticleLesinurad augments uric acid lowering effect in allopurinol non-responders
As the never-ending battle with refractory gout continues, the need for more safe and effective treatments remains. Often, steady remission and target urate levels are not achieved with allopurinol alone.
Read ArticleSeropositivity Increases Risk of Rheumatoid Mortality
Three European registries analyzed their cohorts for outcomes that may be related to seropositivity for anticitrullinated protein antibodies (ACPA), rheumatoid factor (RF) and anticarbamylated protein (anti-CarP) antibodies.
Read ArticleNew Scoring System Predicts 1 year survival in Hip Fracture Patients
A prospective study was conducted in Germany to establish predictors of 1 year survival after a hip fracture in elderly people.
Read ArticleDSB: Managing Methotrexate Toxicity (Best of 2015: #1)
Methotrexate was first introduced in 1955 for leukemia and in 1986 became FDA approved for the treatment of adults with severe, active, rheumatoid arthritis or children with active polyarticular-course juvenile RA.
Read ArticleCan Gout and Rheumatoid Arthritis Coexist?
German investigators studied 100 RA patients with a uric acid > 6 mg/dl and assessed them for MSU crystal deposit with dual energy computed tomography (DECT) of both feet and hands.
Read ArticlePlasmacytoid Dendritic Cells Influences Early, But Not Established Lupus
The Journal of Immunology has published the findings of Virginia Tech researchers who have studied plasmacytoid dendritic cells and their ability to induce type I alpha interferon (IFN-α) in lupus. (Citation source: http://buff.ly/1MceeCl)
Read ArticleSkin Cancer Risk in ANCA+ Vasculitis
Previously, granulomatous polyangitis (GPA or Wegener's) was known to have an increase risk of cancer, especially bladder cancer, presumeably due to cyclophosphamide (CTX) exposure.
Read ArticleMicrovesicles May Ameliorate Arthritis Damage
Microvesicles are emerging as a new mechanism of intercellular communication by transferring cellular lipid and protein components to target cells, yet their function in disease is only now being explored.
Read ArticleAzathioprine Adverse Events Associated with TPMT Polymorphisms
Azathioprine (AZA) is widely used in the treatment of several autoimmune diseases. Its use and optimal dosing may be limited by adverse drug reactions (ADRs). Thiopurine S-methyltransferase (TPMT) is an important enzyme involved in AZA metabolism.
Read ArticleRituximab's Efficacy May Be Correlated with CD4 T Cell Counts
Rituximab (RTX) is highly effective at B cell depletion and this may be one of several hypothetical ways in which the drug works. B cell numbers (measured as CD19+ B cells) plummet rapidly after the first infusion and stay down for 6-12 months.
Read ArticleReduced Uric Acid from Weight Loss Tied to Triglycerides
Weight loss is one of several nonpharmaceutical interventions to reduce serum urate (SUA) levels and control gout. French researchers examined the role of xanthine oxidase (XO), low-grade inflammation, and weight loss on SUA levels in obese patients.
Read ArticleDiffuse Alveolar Hemorrhage in Lupus Reviewed
Diffuse alveolar hemorrhage (DAH) is a rare but catastrophic complication of systemic lupus erythematosus. Presentations are usually acute and the potential for significant morbidity and mortality risk mandates early diagnosis and aggressive interventions.
Read ArticleAngiogenic Biomarkers Predict Adverse Outcomes Pregnancies in Lupus
The PROMISSE (Predictors of Pregnancy Outcome: Biomarkers in Antiphospholipid Antibody Syndrome and Systemic Lupus Erythematosus) study has revealed several important lessons in lupus care.
Read ArticleDiastolic Dysfunction in Rheumatoid Arthritis
Poor cardiovascular outcomes have been linked to inflammation and rheumatoid arthritis (RA). This includes higher rates of MI and heart failure (HF).
Read ArticleFunding for Rheumatology Research in Decline
The Rheumatology Research Foundation and Rheumatology News report that research projects funded by the National Institutes of Health (NIH) dropped by 52% from 2010 to 2014, while the number funded by private foundations fell by 29% over that period.
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