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The RheumNow Week in Review – 10 February 2017

Feb 10, 2017 9:58 am

Dr. Jack Cush discusses the news and reports from this week on RheumNow:

  1. Unlike RA, gout pts sustained a 25% excess mortality rate that has NOT changed in the last 20 yrs. Sobering data. https://t.co/oQdNQA5yit
  2. Jo-1+ pts w/ incomplete antisynthetase syndrome are highly likely to evolve to full triad-ILD arthritis & myositis. https://t.co/iqzipQngcm
  3. Clinical review of anti-GMCSF mAb-mavrilimumab. Preclinical, Phase I/II efficacy & safety in #RA; 60-70% ACR20 resp https://t.co/GyvnSWpo1r
  4. Large cohort of autoimmune Dz, few (87) developed myeloid neoplasm; 7x more w/ AZA & 3.5x more w/ CTX (not MTX, MMF) https://t.co/En5oPKnyBA
  5. Fecal calprotectin commonly followed in IBD. 204 AS pts 2/3 had high levels: fell w/ TNFi, not NSAID;1.5% got Crohns https://t.co/mhQC8t4gql
  6. Belimumab RCTs shows promising renal effects. 55% improved renal outcomes, 71% improved proteinura, renal flare=1.7% https://t.co/4VLHmJmIhb
  7. In 839 active #SLE pts, belimumab yielded 13% more responses, 51d delay in flares, 6.3% more pred reductions VS PBO https://t.co/Ganx0liVh0
  8. Among 331 #RA patients only half received vaccine for influenza and 2/3 failed to receive pneumococcal vaccination https://t.co/a2ZtRmTD97
  9. Diabetics have incr risk of #RA (^37%) thats decreased by HCQ (-33%), abatacept (-48%), higher w/ Pred & statins https://t.co/6HlrnbgxC8
  10. Modest Efficacy for Methotrexate in Psoriasis
    http://rheumnow.com/content/modest-efficacy-methotrexate-psoriasis
  11. Novel Peripheral Helper T Cells in RA 
  12. Intra-articular Corticosteroids or Methotrexate for Oligoarticular JIA? 
  13. Cytoplasmic Autoantibodies in the Anti-Synthetase Syndrome 
Disclosures
The author has received compensation as an advisor or consultant on this subject

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