The RheumNow Week in Review - 23 February 2018 Save

Dr Jack Cush reviews highlights from the past week on RheumNow.com. This week’s video is in two parts; for part Ii, go to https://buff.ly/2BM9MjL

1. Duke Federico of Montefeltro (1422-1482) shown to have #gout based on letters and examination of skeletal remains. Gout was alive and active during the Italian Renaissance. https://t.co/yNnYWZlU5G
2. Gout management by UK Rheums conform to guidelines, yet ~45% reach target SUA<6.0.  Study of 4343 Gout pts; 82% M; 13% crystal-proven. 29% stopped diuretic, 76% on ULT; prophylaxis was co-prescribed for 94%. https://buff.ly/2F0yLlA
3. FDA grants "breakthrough" status to Pfizers Xeljanz (tofacitinib) for phase III trials in atopic dermatitis https://t.co/hzdMTjxmg1
4. Dr. Hyman Zimmerman is famous for drug-induced hepatocellular injury plus jaundice conferring a 10% mortality rate. "Hy's Law" is used by the FDA to judge serious hepatotoxicity and risk of death; Requires evidence of jaundice and ALT/AST >3x ULN https://t.co/qu65fdGscf
5. Australian study shows ACL injuries in children  have increased 148% in 10 yrs (2.74 per 100,000 2005 to 6.79 per 100,000 in 2015). US pediatricians have also reported increases in ACL tears in children/teens. https://t.co/Z5m2vQvlEk
6. PANTS study: Personalized anti-TNF Therapy in Crohn Disease tests real-world eficacy, safety & immunogenicity of infliximab vs biosimilar CT- P13 vs adalimumab. Wk 54 remission rate was 40% INFX, 40% CTP13 & 34% in ADA; immunogenicity was 26%, 28%, 11% https://t.co/irhImH6ipP
7. 3 decade study from Mayo clinic shows the incidence of symptomatic and asymptomatic renal stones increased 14-29% per 5 years in men and women https://t.co/yMmsQkxxHx
8. Dentists are ill at ease providing dental surgery to patients on bisphosphonates. 63% active ask about BP Rx, 85% reluctant to do dental surgery if on BP Rx. https://t.co/pkmuvKGMT3
9. Oral Anticoagulation Effective Following Hip and Knee Replacement Surgery  
10. Are ANA Tests Unreliable 
11. Pediatric Use of TNF inhbitors Does Not Increase Malignancy Risk  
12. HERO Trial - Hydroxychloroquine Fails in Hand Osteoarthritis 
13. Apremilast Continues to Look Good in Behcet's Disease