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SGLT2 Inhibitors in Type 2 Diabetes Lowers Gout Risk

Dec 15, 2021 5:44 pm

A recent study of drugs used in type 2 diabetes (T2DM) shows that SGLT2 inhibitors have a lower risk for gout compared with those receiving DPP4 inhibitors.

The sodium–glucose cotransporter-2 inhibitors (e.g., Invokana, Jardiance, Farxiga) are reported to lower the risk of gout in T2DM patient.  Yet, the use of dipeptidyl peptidase-4 (DPP-4) inhibitors (e.g., Januvia, Trajenta) may cause arthralgia or arthritis, especially over time.

A study of the Taiwan nationwide insurance database showed an 11% risk reduction (HR, 0.89; 95% CI, 0.82-0.96) in the incidence of gout in 47 405 patients with type 2 diabetes who received an SGLT2 inhibitor, compared to a propensity score–matched cohort on DPP-4 inhibitors. 

In T2DM patients SGLT2 inhibitors may be preferred as they have the potential to decrease the incidence of gout .

The author has no conflicts of interest to disclose related to this subject

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