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ACR Best Abstracts - Day 1

Jack Cush, MD

The RheumNow faculty reporters have been glued to their monitors all day, viewing video, reading and listening to abstract presentations and I charged them to earmark those presentations were the “Best” they saw today. Below is the list of most often noted #ACRbest abstracts from Day 1.

Janet Pope Tweet
Janetbirdope
Do pts with RA take their meds & can adherence intervention work? Yes & No. Pts starting new bDMARD RCT of electronic monitoring feedback vs usual care, adherence>80%. Neg RCT Maybe chronic users with poor adherence is group to study abstr#0799 #ACR2020 @RheumNow https://t.co/FyWoBjYnvs
Janet Pope Tweet
Janetbirdope

Which Adalimumab biosimilar to use (if any)? The race is on to have 1st Ada or 2nd reimbursed/preferentially listed in US reimbursement plans & dare I say it mandatory switching like in Europe. Abstr#0798 #ACR2020 compares Abrilada & Humira in RA @RheumNow @CRASCRRheum https://t.co/AUcVZnc6Gj

sheila Tweet
RHEUMarampa
What is your initial csDMARD of choice in pts w/ elderly-onset RA? @RheumNow #ACR20
Eric Dein Tweet
ejdein1
Serial RF titers? Abst#0754 from Japan: Pts with RF>45, tracked RF at month 0/4/12 after starting b/tsDMARD. 46/130 had RF decrease titers, had better radiographic remission/DAS28-ESR. Limits: varied Rx, More aggressive Rx w RF decrease grp @RheumNow. #ACR20
Eric Dein Tweet
ejdein1
#ACR20 @RheumNow. We think of dichotomy of erosive vs. non-erosive but Abst#0748 shows joint space narrowing precedes erosive disease and requires more attention for early recognition. https://t.co/JLd3xVTlXM
Eric Dein Tweet
ejdein1
Will we start getting fine-specificity ACPAs to drive treatment of RA? Abst#0743 shows fs-ACPA (anti-fibrinogen B) predict greater response to ABA+MTX vs MTX alone. #ACR20 @RheumNow. Role of RA antibodies will continue to evolve and guide Rx. https://t.co/pY4mm19Jc7
sheila Tweet
RHEUMarampa

Year in review by @JYazdanyMD ENTRACTE trial: CV safety of TCZ vs. ETN >similar CV events >TCZ grp slightly more infections & GI perforations @RheumNow #ACR20 https://t.co/yBDeHBDB3Z

Meral K. El Ramahi, MD Tweet
MeralElRamahiMD
Abst#0194 at #ACR20 showed that significant symptoms of depression in RA are more frequent than depression diagnosed clinically, suggesting that depression may go undiagnosed and that symptoms of depression predicted mortality in RA patients! @RheumNow https://t.co/GqwXNB45y2
sheila Tweet
RHEUMarampa
ACPA+ and subclinical synovitis does not automatically mean developing to RA. Interesting work by Cleo Rogier et al. Something to consider in pts w/arthralgias & when to start csDMARDs @RheumNow #ACR20 Abstr#481 #ACRbest https://t.co/q3vIITmtq2
David Liew Tweet
drdavidliew
Scoring hand x-rays for Sharp scores is painfully tedious and not always perfectly consistent. Why not get a computer to do it? Turns out you can - a deep adaptive machine learning model does as well as a human, each x-ray in literally one second. #ACR20 ABST0493 @RheumNow https://t.co/SvqkaFy8XZ
sheila Tweet
RHEUMarampa
Zonulin levels ⬆ in pre-RA/RA pts; activation of zonulin signalling leads to ⬆ intestinal permeability. Leaky gut - potential therapeutic target for RA? @RheumNow #ACR20 abs#492 https://t.co/C4TVrWwcYG
David Liew Tweet
drdavidliew
UK Biobank data: RA is associated with not just restrictive but also *obstructive* patterns on spirometry/PFTs (independent of smoking). Consistent observation; direction of causality? The lung in RA continues to fascinate. Prisco @jeffsparks et al #ACR20 ABST0491 @RheumNow https://t.co/LcjtAefnVF
Bella Mehta Tweet
bella_mehta
Shoutout to @SattuiSEMD and @NavarroMillanMD showing #dementia is lower in #RA pts on bDMARDs compared to csDMARDs using CMS data #ACR20 ABS#0488 @RADoctor @RheumNow https://t.co/1XOV2zqKko
Eric Dein Tweet
ejdein1
How do you treat ACPA+, subclinical synovitis (US/MRI+)? Abst#0481 reviews 3 cohorts for progression to clinical inflam arthritis. 44-68% did not progress to IA in 1 year, is DMARD over treating? #ACR20 #ACRBest @RheumNow
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