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Early RA Journey - Patient Perspectives and Uncertainties
Canadian early RA (ERA) patients were interviewd to depict their perspectives from onset and diagnosis to referral and care. This report highlights the importance of patient pain and primary care physician (PCP) intake and referral. PCP and HCP delays in referral to a specialist still exist.
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Biosimilar Slow Growth in USA
A recent Forbes article, "Biosimilars Are Making Inroads In U.S., But It’s Still A Bumpy Ride", reviews the current state and reasons for slowish uptake of these significant cost-savings alternatives to biologic therapy in treating cancer and autoimmune disorders. The following are takeaway bullets from this informative article.
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Dr. Quotes (11.8.2024)
Dr. Jack Cush reviews the news and journal reports from this past week from RheumNow.com.
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Gut microbiome changes linked to onset of RA
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EurekAlert!
Changes in the make-up of the gut microbiome are linked to the onset of clinically evident rheumatoid arthritis in those at risk of the disease because of genetic, environmental, or immunological factors, suggests research published online in the
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COVID-19 and Long-Term Risk of Autoimmune and Autoinflammatory Disorders
A Korean population based study found that people infected with COVID-19, especially severe COVID-19, had an increased risk of autoimmune and autoinflammatory connective tissue disorders.… https://t.co/zlJrusJDM4 https://t.co/cuumClbN6b
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Genes Linking RA and Osteoporosis
People with rheumatoid arthritis often develop osteoporosis, a more serious condition, as a result of the bone damage caused by immune cells and as a side effect of certain medications.
https://t.co/hEJc77gcln https://t.co/bmsV70riUc
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VA #RA registry study of 263 RA-ILD pts (mean 69 yrs, 95% male, 73% W, 85% smokers), finds the MUC5B promoter variant in 33.5%. While the MUC5B variant is assoc w/ RA-ILD risk, it does not predict survival or mortality. Other genetic & nongenetic factor must be responsible… https://t.co/sr1AtAZRDT https://t.co/KKD7RLnIqR
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Taiwan claims data study of 135 230 patients who received antineoplastic medications, found that immune checkpoint inhibitors use was associated with a 2-fold increased risk of developing psoriasis (HR 2.43).
https://t.co/m5eGT56W12 https://t.co/h5FjQpHOpF
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Memory B cells are dysfunctional in #SLE. They are anergic B cell receptor signalling, but responsiveness to Toll-like receptor (TLR) and type I interferon signalling. BCR hyporesponsiveness of memory B cells may explain failure non-depleting B cell Rx in SLE… https://t.co/naBYtgLBGd https://t.co/5sJibS9esn
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Full read JAMA ILD Review article. ILD= 33% idiopathic (IPF) + 15% hypersensitivity pneumonitis + 25% from CTD.
30% of ILD has cough
Chest CT 91% sensitive, 71% specific
5% decr in FVC/12 mos assoc w/ 2-fold incr in mortality
Rx options nintedanib or pirfenidone, TCZ, MMF, RTX… https://t.co/9pET497zjC https://t.co/P8XVlVmmLd
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Overview of Uveitis management of adult & pediatric rheumatology.
- Uveitis accounts for 10% of visual impairment globally
- TNF inhib are effective; w/ IL-6 inhib as 2nd line options https://t.co/CmGuA7W4Ag https://t.co/p5aEQlV7p6
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211 SSc patients, men and younger women, have lower BMD than the population (Osteopenia in 52% & 16.5% osteoporosis; P=0.001). Low BMD in women assoc w/ Finger ulcers, diffuse involvement, older age, & being post-menopausal https://t.co/qyvEJoIbKH https://t.co/zj2Fn1oU5n
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Virtual Yoga Effective in Chronic Low Back Pain
A randomized trial of 140 adults with chronic low back pain (CLBP) demonstrated that virtual yoga instruction resulted in significant improvements in CLBP patients compared to the wait-list control group.
https://t.co/BuYWb1wCXG https://t.co/tQawiZFIJv
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New download available!
Substitute Inflammatory Measures
https://t.co/FiZSvvl5DA https://t.co/QwVefFLcHO
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Serial MRI study of SI & lumbar (LS) joints in 24 early axSpA (Sxs < 5.5yrs) over 3 yrs, showed:
- SIJ developed bone marrow edema, sclerosis & erosion.
- LS: fat lesions decreased & erosions increased.
- Facet joint inflammation (in t0) significantly influenced yr 3. LS bony… https://t.co/COlFAXVE1x https://t.co/4Xs9ngJN4w
Dr. John Cush RheumNow ( View Tweet)
Save the date! RheumNow will be covering #ACR24 from 11/14-11/19. Get ready for daily recaps, live streaming and much, much, more! https://t.co/rDMFH3wlbc
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Overlap Syndrome with ILD
https://t.co/4CG6CU4g2r https://t.co/EFjRrblepN
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Long Covid Defined
While COVID-19 has infected over 7 million worldwide, it is estimated that 7% of adults (and >1% of children) or 15 to 20 million Americans have developed long COVID, a chronic condition with systemic and often disabling symptoms.
https://t.co/9njt8Kqe7P https://t.co/2V5OVlUrfQ
Dr. John Cush RheumNow ( View Tweet)
Advances in the treatment of autoimmune hepatitis
Autoimmune hepatitis (AIH) is a chronic, progressive liver disease caused by immune system dysregulation that targets the liver. If untreated, AIH can lead to severe complications, including cirrhosis and liver failure.… https://t.co/6GtWZ8tDDv https://t.co/YuJrcOyaGP
Dr. John Cush RheumNow ( View Tweet)
Literature review of the treatment of IgA Vasculitis (Henoch–Schönlein Purpura) suggests:
- Glucocorticoids are 1st -line therapy, esp if severe
- For minor HSP: colchicine, dapsone, & methotrexate may be useful
- Also studied cyclosporine A, tacrolimus, MMF… https://t.co/ZoZX3kyHvo https://t.co/dS82ekuEkv
Dr. John Cush RheumNow ( View Tweet)