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RheumThoughts: CNS Lupus (NPSLE) Save
29 yr. old woman with SLE and transverse myelitis. Is this NPSLE; how to diagnose?
Features Dr. Jack Cush
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sir you said that BBB disrubtion is due to infection but in book 2025 dupbos lupus page 591 said that BBB disrubtion is due to NPSLE DIFFUSE OR FOCAL OOOOH WHAT IS THE CORRECT
Sorry for the delay in response. In my study and experience, less than 50% of SLE pts w/ NP-SLE will have BBB disruption - as measured by the Q albumin. But heres the point to remember. An intact BBB has a Q albumin under 9. Over 9 there is some disruption; In NP-SLE the Q albumin abnormalities indicate mildly affected BBB with a Q albumin of 9-15 (in <50%). This is very different from CNS infection (meningitis, encephalomyelitis) or vascular event/vasculitis where the Q albumin values are very very high, often 50-200. I hope this rectifies the difference between what I said and what Dubois Textbook claims
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