The RheumNow Week in Review - 8 December 2017 Save

Dr. Jack Cush covers the news and journal articles published on RheumNow.comin the past week.

1. Systematic review of ULT discontinuation - 5 studies shows that ULT D/C has good short term outcomes (esp if SUA is low) but delayed relapse rates occcuring 1-4.5 yrs later - more in gout (36-81%), less w/ urolithiasis (15%). https://t.co/RTIwuH154S
2. Prospective study of 133 IBD pts (64% CD, 36% UC) switched from Remicade to biosimilar Inflectra. After 12 mos. no differences in drug levels, disease activity between innovator and biosimilar. https://t.co/QEH3lUaXD4
3. FDA grants orphan drug designation to SER-287 a microbiome drug to treat dysbiosis of pediatric ulcerative colitis. Will microbiome targeted therapies be the next (safe) best thing? https://t.co/PmOLeyLyy3     
4. Patients with autoimmune connective tissue diseases (CTDs) undergoing abdominoplasty are at higher risk for certain complications (hematomas, venous thromboembolism, need for transfustions and longer hospital stays) https://t.co/AXLKNg0ag2
5. Coffee consumption (3-4cups/day) assoc w/ 17% reduction in all cause mortality, 19% for CV mortality, 18% lower Cancer risk; but in pregnancy, high versus low/no consumption was associated with 30% increase in low birth weight and pregnancy loss (OR 1.46). https://buff.ly/2iNa7M0
6. TWO simple tests to diagnose #Fibromyalgia in primary care: 1) for tenderness to digital pressure at 10 body sites; 2)  single question, “I have a persistent deepaching over most of my body” (0–10)  https://buff.ly/2iIx03s
7. 2005-20014 - prevalence of one comorbidity assoc w/ pregnancy & delivery increased 50% (66.9 to 91.8 per 1,000 delivery hosp.) in the USA. The frequency of multiple chronic conditions doubled ( 4.7 to 8.1/1000 delivery) during this sameperiod. https://buff.ly/2iNuDMx
8. Infliximab Does Not Increase Perioperative Infection 
9. Ixekizumab (Taltz) FDA Approved for Psoriatic Arthritis 
10. Do JAK Inhibitors Increase the Risk of Venous Thromboembolic Events? 
11. Why TNF Inhibitors May Work in Some Autoinflammatory Patients