Hematologic Malignancies Increased in Systemic Sclerosis Save
Swedish national study found that among a cohort of systemic sclerosis (SSc) patients a two-fold increase risk of hematological malignancies was seen.
Data included Swedish patients seen between 2004–2019 and compared 1720 individuals with incident SSc, matched agains general population (n=16 983).
SSc patients had a higher risk of hematological malignancies (HR 2.2, 95% CI 1.4 to 3.1), especially B-cell malignancies (HR 3.0, 95% CI 1.7 to 4.8). This risk was highest in men (HR, 3.1; 95% CI, 1.4-5.7) and in individuals aged 18–49 years at SSc diagnosis.
Cancer presentation varied, with myeloid malignancies presenting a median 0.1 (IQR 8.2) years after SSc diagnosis, while lymphoid malignancies presented a few years later (median 3.1 yrs).
SSc patients should be screened for hematological malignancies, especially around the time of diagnosis and especially in men.
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