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FDA Approves Taltz for Psoriasis
Tuesday the FDA approved the IL-17 inhibitor, Taltz (ixekizumab) for adults with moderate to severe plaque psoriasis. (Citation source http://buff.ly/1py10wd)
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Statin-Induced Autoimmune Myopathy
The CDC estimates nearly 71% of adults with cardiovascular disease and 54% of adults with hypercholesterolemia use a cholesterol-lowering
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Differences in Diuretic-Induced Gout
Diuretics are frequently implicated causes of hyperuricemia and gout. And there are gout variants wherein age, renal dysfunction and diuretic use may give rise to gouty attack in the hands of women with nodal osteoarthritis.
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The Week in Review 18 March 2016
See the highlights from the past week that appeared on RheumNow.com, and watch Dr. Jack Cush as he reviews each of them.
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January/February 2016 Top Social Media News
In February 2016, RheumNow published 82 tweets about impactful news, research and teaching points that impact the rheumatology community. These feeds had a reach (impressions) of 80,800 with, 76 mentions, and over 2700 visits to learn on RheumNow.com.
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Sclerostin Inhibition May Worsen Rheumatoid Arthritis
Sclerostin, an inhibitor of the Wnt/β-catenin pathway, negatively regulates osteoblast differentiation and has anti-anabolic effects on bone formation. Thus, inhibition of sclerostin is currently being studied as therapy for postmenopausal osteoporosis.
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TNF Inhibitors Increase Perioperative Infection Risk
The use of tumour necrosis factor α inhibitors (TNFis) at the time of major surgery has been a challenge for surgeons, rheumatologists and those wishing to develop evidence-based guidelines for this clinical scenario.
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IL-6 Inhibition Makes News
Several new interleukin-6 inhibitors made headlines this week. While none of the new IL-6 inhibitors are soon to be approved and available, these studies may redefine the role of other non-TNF biologics in the future.
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Tocilizumab Induces and Maintains Remission in Giant Cell Arteritis
Lancet has reported the results of a randomized, double-blind, placebo-controlled trial of tocilizumab in patients with new-onset giant cell arteritis (GCA).
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Drugs that May Induce Raynaud's
A systematic review by Khouri examined the extent drugs are capable of inducing Raynaud's phenomenon (RP).
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Methotrexate Safety with Chronic Hepatitis B Infection
Chronic liver disease, and in particular hepatitis B infection, is a contraindication to methotrexate (MTX) use.
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TNF Inhibition and Heart Failure
Clinicians often face the issue of using a TNF inhibitor (TNFi) in patients with heart failure or cardiac disease. Here are the facts and data necessary to make a cogent decision to use or avoid TNFi.
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Cell Phone Study Proves Car Crash Risk
In a study published in Proceedings of the National Academy of Sciences, researchers enrolled over 3,500 U.S. drivers, aged 16 to 98 years, and followed them for a three-year period after rigging their vehicles with internal video cameras and devices to track speed and location.
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Curbside Consults - February 2016
The following is a collection of cases presented to me by rheumatology colleagues. Each has a challenging therapeutic or safety issue. Answers are based on experience with references from literature and guidelines.
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Transdermal NSAID Touted as an Advance
Reuters reports that researchers at the University of Warwick have devised a new transdermal drug delivery patch that may change the future of pain management.
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Febuxostat Safe in Gout with Moderate-Severe Renal Impairment
Renal impairment is a risk factor for gout and a barrier to optimal gout management. Many of the drugs used to treat gout require adjustment in those with renal disease.
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Hidradenitis Suppurativa Increases Cardiovascular Event Risk
Hidradenitis suppurativa (HS) is a chronic inflammatory disease affecting exocrine glands with painful abscesses in intertriginous areas.
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RWCS 2016 - Updates in AS, PsA and Lupus
Update on Ankylosing Spondylitis and Spondyloarthritis
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