EULAR Recommendations on Large Vessel Vasculitis

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Th European League Against Rheumatism (EULAR) recommendations for the management of large vessel vasculitis (LVV) was originally published in 2009. Since then there have been new randomised clinical trials and cohort analyses leading to an update the original recommendations.

FDA Approves Apremilast for Behcet's Oral Ulcers

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The US Food and Drug Administration (FDA) has approved apremilast (Otezla) for the treatment of oral ulcers associated with Behçet’s Disease, a rare chronic multisystem inflammatory disease that affects about 5 in 100,000 persons in the USA.

RheumNow Podcast – EULAR 2019 Streamin' - (6.14.19)

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Editor's note: July 1 - 5, RheumNow is running the best of the EULAR 2019 meeting. Dr. Jack Cush reports from Madrid on several novel presentations from EULAR 2019, including low-dose steroids in hand OA, ABA vs. ADA in double positive RA patients, psoriasis predictors of PsA, tildrakizumab and more.

Steroids in GCA and PMR Increase Infectious Risk

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A large study of UK family practice patients shows that polymyalgia rheumatica (PMR) or giant cell arteritis (GCA) patients treated with glucocorticoids are at an increased risk of bacterial, viral, parasitic and fungal infection, even at daily doses of less than 5 mg prednisolone.

RheumNow Podcast – EULAR 2019 Streamin' - (6.14.19)

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Dr. Jack Cush reports from Madrid on several novel presentations from EULAR 2019.

1. Genovese Vagal nerve stimulator in RA

Management of Hemophagocytic Lymphohistiocytosis (HLH) in Adults

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Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome induced by activated macrophages and cytotoxic T cells.  HLH manifests recurrent fever, cytopenia, liver dysfunction, and a sepsis-like syndrome that may complicated by multiple organ failure.

RheumNow Podcast – Rituximab Monitoring (5.31.19)

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Dr. Jack Cush presents the news and best of rheumatology and medicine from the past week on RheumNow.com

RheumNow Podcast – Periodontitis in RA Relatives (5.10.19)

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Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com

Calcineurin Inhibitors in Anti-Synthetase Dermatomyositis ILD

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A pilot treatment study of patients with anti-aminoacyl-tRNA synthetase antibody–positive polymyositis/dermatomyositis-associated interstitial lung disease (anti-ARS-PM/DM-ILD) shows therapy with glucocorticoids and calcineurin inhibitors (CNI) to be highly effective. 

High GPA Hospital Readmission Rates

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A national database reveals that patients with granulomatosis with polyangiitis (GPA) have 22.3% risk of hospital readmissions within 30 days of discharge. 

From a total of 9749 hospital admissions with GPA, there were 2173 readmissions within 30 days of discharge.

Ustekinumab Effective in Behcet's Disease

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A small prospective study has shown that ustekinumab is safe and effective in Behçet's disease (BD) with recurrent oral ulcers (OU).

Timing of Shoulder Injections Impacts Surgical Infection Risk

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A study of patients undergoing arthroscopic rotator cuff repair shows that corticosteroid injections in the month prior to surgery are associated with a significantly increased risk of surgical site infection.

GCA Relapse Risk High with Steroids

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Prior to the introduction of tocilizumab to manage giant cell arteritis (GCA), glucocorticoids (GC) have been the mainstay of therapy, but has been limited by relapses in disease.

RheumNow Podcast – Loretta Lynn Arthritis (3.29.19)

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Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com.

Cyclosporin and IVIG Effective in Kawasaki's Disease

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A Lancet study has shown that adding cyclosporin to intravenous immunoglobulin (IVIG) Kawasaki disease patients, who were predicted to be resistant to IVIG, was both safe and effective in averting severe coronary artery outcomes.

Stopping Biologics Before Joint Surgery: Is Earlier Better?

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Withholding intravenous abatacept (Orencia) for longer than a month before hip or knee arthroplasty among patients with rheumatoid arthritis (RA) did not lower the risk for postoperative infection, a retrospective claims-based analysis found.

Noninfectious Proximal Aortitis Needs Serial Follow-ups

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A Cleveland Clinic review of patients undergoing thoracic aortic surgery (1996‐2012) identified 196 patients with histopathology‐proven non‐infectious aortitis.

Ten Contemporary Challenges Facing Lupus Treatment

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A group of French researchers have pooled their interests to identify the challenges ahead in the management of patients with systemic lupus erythematosus (SLE). 

Does Methotrexate Work in Giant Cell Arteritis?

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There seems to be both hope and uncertainty regarding the use of weekly methotrexate (MTX) in giant cell arteritis (GCA) patients whom need to limit their glucocorticoid use.

IL-6 Blocker Succeeds in Real-World Vasculitis

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Tocilizumab (Actemra) was effective for refractory giant cell arteritis (GCA) in real-world practice, although serious infections occurred relatively frequently, Spanish investigators reported.