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COVID 19 Updates from RheumNow

Does Fibromyalgia Need B12? (9.9.2022)

Can we predict the bad outcomes? Like when ITP evolves into SLE; or when psoriasis will develop arthritis; or if Sjogren's will develop lymphoma? Let's dive in and review these journal reports and this past week's news from RheumNow.com.

Goofy But True

Dr. Jack Cush discusses declining survival rates in the USA, FDA approvals of new COVID subvariant boosters and other odd and possibly true new research reports from the past week on RheumNow.com.

FDA Approves BA.4 and BA.5 Omicron COVID Booster Vaccines

Today the FDA authorized the updated Omicron subvariant (BA.4 and BA.5) COVID-19 booster shots manufactured by Pfizer and Moderna; with an anticipated ship/start date of early September 2022. The BA.5 subvariant accounts for more than 88% of U.S. infections.

Influenza Vaccination Recommendations

CDC

The CDC has published an update to the recommendations from the Advisory Committee on Immunization Practices (ACIP) on the use of seasonal influenza vaccines in the United States for the 2022-23 season.

Hit Parade Review (8.12.2022)

We've got a lot to discuss this week: psoriasis; fatigue; sleep; sural nerve biopsies; uveitis and SpA; diet and RA; tofacitinib and the ORAL surveillance study; what not to take with mycophenolate - and more. In what order should these items be discussed?

The Great Unknowns (8.5.2022)

Dr. Jack Cush reviews the news, FDA approvals, journal articles from the past week on RheumNow; plus viewer questions. This week great hopes for vitamin D, the great unknows of CSA and the great big mess that is the gout.

ACR Updated Guideline on Vaccinations for Rheumatic Patients

The ACR has posted a new ACR Clinical Practice Guideline Summary providing recommendations on the use of vaccinations for children and adults with rheumatic and musculoskeletal diseases (RMDs).

ICYMI: 2021 Rheumatology Year in Review

Editor's note: This podcast originally appeared January 8, 2022. 

“One faces the future with one’s past” – Pearl S. Buck

2021 was the year we waited for the other shoe to drop; with the pandemic stone in your shoe, you waited for:

What Worries You, Masters You (7.1.2022)

Dr. Jack Cush reviews recent news, regulatory and guideline updates from the past week on RheumNow.com.  Studies on methotrexate use, COVID vaccination, Supplements and vitamins, and arthrocentesis despite anticoagulation are discussed.

Two Week Methotrexate Hold with COVID-19 Vaccination

A cohort study of rheumatoid arthritis (RA) patients evaluated immunogenicity of COVID vaccination with and without holding methotrexate (MTX) for and 2-weeks and showed better immunogenicity, but more RA flares with the second MTX withdrawal. 

COVID-19 Death is Dependent on Age and Type I IFN Autoantibodies

A study in PNAS of has shown that autoantibodies against type I interferons (IFNs) are strong predictors of death from COVID-19.

What Happened to Kawasaki Disease During COVID-19?

During the COVID-19 pandemic, a new COVID-related syndrome in children, the "Multisystem inflammatory syndrome in children" (MIS), was described as being similar to but distinctly different than

Social

Industry Payments to Rheums Dropped During COVID Having their clinics shut down and patients staying away during the COVID-19 pandemic was bad enough for physicians' finances, but now a new study finds that payments from industry dried up as well. https://t.co/jsxw23tTyY https://t.co/5PiaRpiSa4
Dr. John Cush @RheumNow ( View Tweet )
1 year ago

Anakinra Phase 2/3 study in severe hosp. COVID-19 pts (5/20-3/21) w/ pneumonia & hyperinflammation (incr levels IL-6, ferritin, CRP, LDH). 179 pt Rx w/ ANA or SOC - d15 need for Mech ventilation was 77% ANAK v 86% SoC (NS; RR 0.90; 0.77-1.04) https://t.co/CFcI1qTsU2 https://t.co/wAj4pHN5Dh

Dr. John Cush @RheumNow ( View Tweet )
1 year ago
Paxlovid (Nirmatrelvir-Ritonavir) should be used w/in 5d of COVID Sxs onset. Drug interactions include: steroids, anticoagulants (Eliquis, Xarelto, warfarin), Flomax, Calcium channel blockers, benzodiazepines. https://t.co/VZpS1z3OGR https://t.co/hR6JAJ3BBO
Dr. John Cush @RheumNow ( View Tweet )
1 year ago
Autoimmune-Rheum Dz (AIRD) flares occur in 10% w/ COVID vaccination, esp in pts w/ comorbidities, autoimmune morbidities & mental health disorders & Moderna vaccine. 3453 AIRD pts who recv Vax 9.5-11.3% had clinical flares (Arthritis 62% & fatigue 59%) https://t.co/C0WA2Znixl https://t.co/vXzL8XR7kd
Dr. John Cush @RheumNow ( View Tweet )
1 year ago
Autoimmune-Rheum Dz (AIRD) flares occur in 10% w/ COVID vaccination, esp in pts w/ comorbidities, autoimmune morbidities & mental health disorders & Moderna vaccine. 3453 AIRD pts who recv Vax 9.5-11.3% had clinical flares (Arthritis 62% & fatigue 59%) https://t.co/RCtQnA9vc9 https://t.co/G5cXukkpUB
Dr. John Cush @RheumNow ( View Tweet )
1 year ago
Great #RNL2023 Plenary with "Miracle Larry" after 128 days in hospital for COVID-19, on 3-year anniversary of going into coma "I am the expert on what this virus can do. I don't want the world to ever forget" @RheumNow https://t.co/kTuDXDhTtQ
1 year ago
Tremendously emotional (and unfiltered) first person account of his fight with COVID-19 by Miracle Larry who thanked our Dr. Cush @RheumNow for his ingenuity in fighting COVID-19, thanking healthcare workers for all they do, and reminding us to be empathic. #RNL2023 https://t.co/i0D7r8dR8n
Robert B Chao, MD @doctorRBC ( View Tweet )
1 year ago
Lancet metanalysis shows pts infected w/ SARS-CoV2 are conferred very high degree of re-infx from pre-omicron variants, even after 40 weeks. Protection was lower for omicron BA.1 & declined over time. Protection from severe Dz was high for all variants. https://t.co/RNgYVWQfNo https://t.co/J8U37NYXPP
Dr. John Cush @RheumNow ( View Tweet )
1 year ago
CDC: Nursing home residents not up to date w/COVID-19 vaccines have 30%–50% higher risk for COVID infx vs those up to date. Betw 2022-23 Those vax had COVID rate of 7.2-15.6/1000pts vs 9.5-18.8/1000 pt in those unvaccinated. https://t.co/Eem2H5AMoN https://t.co/o2ZyPVswZp
Dr. John Cush @RheumNow ( View Tweet )
1 year 2 months ago
UK Database 1,955 breakthrough COVID-19 infxs in 54,576 #gout pts compared to 52,468 w/o gout saw more in gout (adj HR 1.24), also w/ more #COVID hospitalizations (adj HR 1.30) & death (1.36), more so in women. Same for unvaccinated https://t.co/596KvupZxi https://t.co/BJJguQBdin
Dr. John Cush @RheumNow ( View Tweet )
1 year 3 months ago