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COVID 19 Updates from RheumNow

HHS, FDA & CDC Joint Recommendation on COVID Booster

FDA

Today, public health and medical experts from the U.S. Department of Health and Human Services (HHS) released the following statement on the Administration’s plan for COVID-19 booster shots for the American people.

Booster Shots for Rheumatology Patients on Immunosuppressive Medications

ACR Press Release

ATLANTA – The Centers for Disease Control and Prevention’s (CDC) Advisory Committee on Immunization Practices today recommended that rheumatology patients being actively treated with high-dose corticosteroids, alkylating agents, antimetabolites, tumor-necrosis factor (TNF) blockers, and other bio

RheumNow Podcast – Booster Shots for COVID (8.13.2021)

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com.

Anakinra's Effects on COVID-19 Outcomes

Sporadic reports of anakinra use in COVID-19 infection has hinted is potential; now a metanalysis shows that the use of anakinra may reduce the mortality risk in patients admitted to hospital with moderate to severe COVID-19 pneumonia, especially highly elevated ferritin and C-reactive protein (C

COVID Vaccine Booster Effective for Transplant Recipients in Small Trial

MedPage Today

For organ transplant recipients, a third dose of Moderna's COVID-19 vaccine more than tripled the proportion with a sufficient antibody response, a randomized trial showed.

Rare Risk of Serious Adverse Events After COVID Vaccination

CDC/MMWR

The CDC had reported the Advisory Committee on Immunization Practices (ACIP) study of rare serious adverse events after COVID-19 vaccination and assert that the excessive morbidity and mortality from COVID-19 (and the protection afforded by vaccination) far exceeds the risk of rare safety signals

RheumNow Podcast – Psoriatic Arthritis Without Psoriasis (7.30.2021)

Dr Jack Cush reviews rheumatology and COVID news from the past week on RheumNow.com.

CDC Reverses Stance on Masks

Today the Centers for Disease Control and Prevention (CDC) said that masks should be used by those vaccinated against the coronavirus in public indoor spaces in parts of the country where the virus is surging.

DMARD Effects on COVID-19 Outcomes

Sparks and colleagues have published data from the Global Rheumatology Alliance noting that among rheumatoid arthritis (RA) patients afflicted with COVID-19 infection, there was little influence of their baseline biologic or targeted synthetic (b/ts) disease-modifying antirheumatic drugs (DMARDs)

Canakinumab Fails to Improve COVID-19 Survival

JAMA has published the findings of trial wherein the anti–interleukin-1β antibody canakinumab (CAN) failed to improve survival in patients hospitalized with severe COVID-19.

Rare Myocarditis Risk following COVID-19 Vaccine

CDC/MMWR

MMWR review of the risk of myocarditis and pericarditis reports a June 23, 2021 recommendation by the Advisory Committee on Immunization Practices that the benefits of COVID-19 vaccination clearly outweighed the risks of myocarditis after vaccination. 

ICYMI: RheumNow Podcast – Tofacitinib Safety Concerns

Dr. Jack Cush reviews and discusses the news and journal reports from the past week on RheumNow.com.

Social

Can I get the INFLUENZA and COVID Vaccines together? The CDC says: "YES...both vaccines can be given at the same visit, people should follow the recommended schedule for either vaccine.... ideally get a flu vaccine by the end of October." https://t.co/T49zm6Cxyc

Dr. John Cush @RheumNow ( View Tweet )

1 month ago
New study on #COVID19Vaccine in autoimmune cytopenias 🩸7.4% had clinically significant ⬇️ in counts 🩸 All successfully managed w/steroids & transfusion 🩸 Mild ⬇️ in 10% AIHA and 20% ITP ⭐️Vaccination safe with close monitoring⭐️ https://t.co/qGZe6LiPKz

AmericanJournalofHematology @AjHematology ( View Tweet )

1 month ago
Prospective study of 77 RA patients in remission --> vax w/ BNT162b2 (BioNTech-Pfizer) (w/ temp D/C of DMARDs per ACR) found a vaccine-related flare rate of 7/8% (6 pts) w/ 5/6 flares after 2nd dose (2.6 days), resolved w/in 2 wks https://t.co/YOL3YVS2ne

Dr. John Cush @RheumNow ( View Tweet )

1 month ago
MMWR reports real world vax efficacy in 3,689 adults (21 states) found better results w/ Moderna (93%) than Pfizer (88%) than Janssen (71%). 2 dose mRNA vaccines were more effective than 1 dose Janssen COVID vaccine https://t.co/phmPdB9dTW

Dr. John Cush @RheumNow ( View Tweet )

1 month ago
Maker Trade name Generic PFIZER Comirnaty Pfizer-BioNTech COVID-19 Vaccine FDA approved MODERNA Spikevax Moderna COVID-19 Vaccine - EUA currently J&J (pending) Janssen COVID-19 Vaccine- EUA currently https://t.co/MM7XiSCczl

Dr. John Cush @RheumNow ( View Tweet )

1 month 1 week ago
Addendum: Other conditions w/ a 1.2-2 fold higher risk of COVID death (admission) were CKD, hematologic cancer, epilepsy, COPD, CVD, stroke, atrial fibrillation, CHF, thromboembolism, PVD, type 2 diabetes. https://t.co/bbDsb1zLhX

Dr. John Cush @RheumNow ( View Tweet )

1 month 1 week ago
Addendum: COVID deaths increased w/ age, deprivation, male, Indian & Pakistanis. Highest risk w/ Down’s syndr (HR 12.7), renal transplant (8.1), sickle cell (7.7), Nursing home (4.1), chemotherapy (4.3), HIV/AIDS (3.3), liver cirrhosis (3), CNS dz (2.6) https://t.co/bbDsb1zLhX

Dr. John Cush @RheumNow ( View Tweet )

1 month 1 week ago
Breakthrough infections from UK QResarch database: Among 6.95 million vaccinated, 74.1% recv two vaccine doses, there were 2031 covid-19 deaths & 1929 hosp admissions; ~4.0% deaths & admissions were >14 days after 2nd dose https://t.co/bbDsb1zLhX

Dr. John Cush @RheumNow ( View Tweet )

1 month 1 week ago
Analysis of existing #COVID data - as of 7/15/21, 114.9 million adults infected with COVID-19 in US. Overall population immunity (Infx+vax) is 62%, highest in adults >65yrs (77.2%); lowest in children <12 yrs (17.9%) https://t.co/EYiBUaQBLY

Dr. John Cush @RheumNow ( View Tweet )

1 month 1 week ago
ICYMI: American College of OBs & GYNS and the Society for Maternal-Fetal Medicine both enthusiastically endorse COVID Vaccination of pregnant women, given the delta variant, low vax rates in Preg women and poor COVID outcomes in preg. https://t.co/AmP5eOEgr3 #RheumNow https://t.co/wXeT1KDCrJ
Dr. John Cush @RheumNow ( View Tweet )
1 month 1 week ago
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