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Hydroxychloroquine Shows No Benefit in Hospitalized COVID-19 Patients

Oct 09, 2020 11:46 am

The NEJM reports on a controlled clinical trial showing patients hospitalized with Covid-19 given hydroxychloroquine (HCQ) do not have a lower incidence of death compared to those receiving routine care.

A total of 4716 patients who were hospitalized with Covid-19 were randomly to receive HCQ (1561 patients) or usual care (3155). The primary endpoint was 28-day mortality.

Death rates at 28 days were:

  • HCQ: 421 patients (27.0%)
  • Usual care: 790 (25.0%) (rate ratio, 1.09; 95% confidence interval [CI], 0.97 to 1.23; P=0.15).

Hospital discharge within 28 days was the same between groups (59.6% vs. 62.9%).

These findings confirm earlier uncontrolled and controlled reports showing hydroxychloroquine to have no protective effects in treating Covid-19 patients. 

The author has no conflicts of interest to disclose related to this subject

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