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Canary in a Coal Mine (4.19.2024)
Dr. Jack Cush reviews regulatory reports, news and novel journal articles - this week focusing on Sjogren's, ILD, Gout and Uveitis.
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SGLT2 Inhibitors Lowers Gout Risks in Type 2 Diabetes
A population-based cohort has demonstrated that sodium-glucose cotransporter-2 inhibitors (SGLT2i) use in gout patients is superior to sulfonylurea therapy in lowering the risk of incident gout and recurrent flares among patients with type 2 diabetes (T2D).
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RA-ILD at Higher Risk for Serious Infection and Death
A prospective, multicenter study from Spain has demonstrated higher rates of mortality and serious infection in rheumatoid arthritis–associated interstitial lung disease (RA-ILD) patients.
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Lupus Accelerating Breakthroughs Consortium Partners with FDA
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EurekAlert!
The Lupus Research Alliance (LRA), founder and administrator of the Lupus Accelerating Breakthroughs Consortium (Lupus ABC), announced today at the Consortium’s first anniversary meeting an expanded partnership with the U.S.
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Lupus Accelerating Breakthroughs Consortium Partners with FDA
https://t.co/GW7Zy72oIZ https://t.co/AGYY8WDKcK
Dr. John Cush RheumNow ( View Tweet)
Retrospective study of hand/feet Xrays in early/suspected #RA due to low prevalence of erosions (4.4%) seldom leading to change in Dx (2pts; 0.3%) or prognosis change (0.4%). Seronegative had less erosions; Longer Sxs not assoc w/ erosions https://t.co/YCj04ZlQJq https://t.co/fHf6EvGOyc
Dr. John Cush RheumNow ( View Tweet)
BSR Guideline on Management of Sjogren’s Syndrome
Sjögren disease (SD) is the most common of all autoimmune disease, yet little is know of its etiology and there are insufficent interventions for those affected with mucosal or systemic manifestations.
https://t.co/Y8hNoBmBn3 https://t.co/up5motCwkp
Dr. John Cush RheumNow ( View Tweet)
The lateral foot/ankle anatomy 🥰 https://t.co/yuGt1seUd4
Faraz Sethi farazzledphysio ( View Tweet)
Did you know the first clinical controlled trials were done on sailors with scurvy? They were randomized to: a quart of cider, HCl, 2 spoons of vinegar, pint of sea water, spicy nutmeg paste w/ water vs. 2 oranges and a lemon. Guess which sailors fared best? #RheumGR @UTSWRheum https://t.co/fAeCeIxZ9e
TheDaoIndex KDAO2011 ( View Tweet)
AbbVie announced preliminary positive results from phase 3 SELECT-GCA study showing remission in 46% of #GCA pts Rx w/ upadacitinib for 52wks (vs 29% PBO); RCT included a 26-wk steroid taper regimen https://t.co/lqGVHKw3XF https://t.co/EyLuf8QLZA
Dr. John Cush RheumNow ( View Tweet)
PJP PPx in AAV
@anisha_dua #RNL2024 @RheumNow
919 GPA pts on RTX - only 31% on TMP/SMX
13 pts devel PJP, not on PPx
Overall decreased serious infections (HR 0.5), outpt infections HR 0.7
Adverse effects on TMP/SMX 29.6 vs 13.4
For every serious ifn avoided, 2-3 pts will have AE
Dr. John Cush RheumNow ( View Tweet)
Metrics Used by Rheumatologists in RA https://t.co/Pu40jbqhHR https://t.co/jtMm5odrxU
Dr. John Cush RheumNow ( View Tweet)
GPA Management in 2024
https://t.co/ASmIAS4XrT https://t.co/t4AlNInuzG
Dr. John Cush RheumNow ( View Tweet)
Peripheral dermatomes & key muscles of the most important lumbosacral
nerve roots. However, keep in mind that the muscles also receive contributions from other nerves (e.g., the extensor digitorum longus is innervated mainly by L5, but also from L4 and S1). https://t.co/auXMMddUIh
Dr. OMID BANDARCHI OBandarchi ( View Tweet)
#peritendinous #ultrasoundguidedinjection with #osteniltendon for Tendinopathy of the #tibialisposterior #tendon #mskus #pocus #pocushub #GElogiqE10r3 https://t.co/8qe1G27tAl
Dr Jörg Dünkel SportklinikBern ( View Tweet)
ICYMI: Vasculitis Pearls
https://t.co/7z6b0Wj37X https://t.co/PHlOvFG9qQ
Dr. John Cush RheumNow ( View Tweet)
Biopsy Results in Sjogren's Syndrome Save
A prospective study from the Netherlands analyzed the comparative value of simultaneous labial and parotid salivary gland biopsies performed in patients with sicca complaints and suspected SjD.
https://t.co/meJgf7dI8N https://t.co/zHg6SgiufS
Dr. John Cush RheumNow ( View Tweet)
FDA has approved a ustekinumab biosimilar (ustekinumab-aekn; AKA Selardsi), made by Teva & Alvotech, for the treatment of moderate to severe plaque psoriasis (PsO) and active psoriatic arthritis (PsA) in both adults and pediatric pts.https://t.co/ZXvFjjH7Qt https://t.co/7FJKxSVAgL
Dr. John Cush RheumNow ( View Tweet)
#RNL2024 @philseo: I now give Tociliizumab for nearly all patients with GCA
GiACTA shows we weren't doing well enough w/steroid monotherapy
GiACTA shows dosing frequency does not make big diff in new diagnosis, but makes a diff in relapsing disease https://t.co/khJe0bwKXy
Links:
Dr. John Cush RheumNow ( View Tweet)
GCA pts on Toci mgmt
#RNL2024 @RheumNow
@philseo rec's increase interval to q4w before d/c TCZ
Limited evidence from this from study of 17 patients where weaned off TCZ. Hopes to capture pts with mild flares with tapering dose.
MAGICA trial will study abrupt d/c v wean dose
Dr. John Cush RheumNow ( View Tweet)