Location, Location, Location (7.26.2024)

Jack Cush, MD

Jul 26, 2024 8:49 am

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. Location matters; Geo-rheumatology?

Metformin Protects? TrinetX retrospective propensity matching study compared SLE pts on metformin (n 9,178) vs NOT (78,983). SLE NOT on metformin had signif higher risk of lupus nephritis (RR 1.70), CKD (1.27), & MACEs (1.21) & persited for 5yrs https://buff.ly/3WnsBlf
DBRPCT of Krill oil (4 g/d;KOC) vs PBO in 78 #SLE pts for 24 wks. KOC Rx pts had signif increase in Omega-3 Index 4.3% to 7.17% (4wks) to 8.05% (24wks) w/ no change SLEDAI-2K. But 9pts w/ hi activity (SLEDAI≥9) showed signif Dz activity improvements https://buff.ly/4cT1HIM
Cross-sectional study of 154 adult DLE pts in the Philadelphia area assessed DLE Dz severity (by CLASI) & geoghraphic distribution to ID area deprivation (ADI). ADI > 5 (geospatial disadvantaged) was assoc w/ signif (4X) higher risk of mod-Severe Damage https://t.co/dgeGwzNTKm https://t.co/B3hmUE1G9U
Geography of Arthritis-attributable Pain in the USA The journal Pain highlights geographic differences in arthritis pain and outcomes, mainly in the Deep South and Appalachia. Severe arthritis pain is more prevalent in the SW, PNW, GA, FL, and ME regions. https://t.co/e4VuUDWoQt
2001-2004 NHANES population study shows 28% report hx of erectile dysfunction (ED) & 19% w/ arthritis. Having arthritis was assoc w/ 4 fold higher ED risk; mostly in #OA (OR=1.11), RA (OR=1.03). https://t.co/L2LhEPH9DY
Inpatient study 5495 Adult Stills Dz (AOSD) hospitalizations (2016–2019). Pts w/ HLH (6.2%) had higher mortality (9% vs 1.5%). Deatjs Independent predictors: DIC (OR 6.1), liver failure (7.2), Infx (3.7), resp failure (6.9), thrombotic microangiopathy (14) https://t.co/BQsbVnw2Ir
UK study of pneumococcal vaccination in UK, shows IMID pts had suboptimal vax against pneumococcus. In 32 277 pts (RA 14151, IBD 13631, SpA 3804, SLE 691) saw 57% vaccinated; lower if <45 yrs (32%), IBD (42%). Vax not associated w/ IMID flare https://t.co/y5JHYaEpA9
From LG cohort of myeloid neoplasms (861 MDS, 640 AML, 112 MDS/MPN, 89 MPN) autoimmune Rheum Dz (AIRD) found in 7.7% (lit suggests 8-30%), less in AML (4.7% vs 9.5% others). Common: RA (42%), CTD(18%), PMR (14%), vasculitis (12%), AxSpA (7%). https://t.co/ZXxOrZBunZ
3 yr German laboratory study of 71,597 laboratory tests, found 238 positive tests for 13 myositis autoAbs in 209 patients. Pos. results due to Idiopathic inflammatory myopathy in 37 (18%), other inflammatory rheum Dz 90 (43%) or NO Rheum Dx 82 (39%) https://t.co/KKg0X1AyU1
JAMA Patient Education Handout on Polymyalgia Rheumatica (PMR) https://t.co/J1rpcRltM3
RA & OA: Nearly 40% have Anxiety, Depression or Fibromyalgia
Bad News Coronary Artery Calcium in Rheumatic Patients