Microvascular CV Disease with Severe Psoriasis Save
While comorbidities, including an increased cardiovascular (CV) risk, are associated with severe psoriasis, less is known about subclinical CV disease and when it occurs in patients with psoriasis.
Coronary microvascular dysfunction (CMD) has been shown to be predictive of future cardiovascular outcomes and was studied in a cohort of 448 psoriasis patients, who underwent transthoracic Doppler echocardiography to evaluate coronary microcirculation.
From this population, 32% showed CMD that was shown to be correlated with PASI scores, longer disease duration, the presence of psoriatic arthritis, and hypertension - all independently associated with CMD.
An increase of 1 point of PASI and 1 year of psoriasis duration were associated with a 5.8% and 4.6% increased risk of CMD.
This study shows that coronary microvascular dysfunction (from Doppler ECHO) was linked to the severity and duration of psoriasis, supporting the role of systemic inflammation in CMD.
Patients with psoriasis and Psoriatic arthritis should should be evaluated for CMD, especially with severe disease.