Dr. Quotes (11.8.2024) Save

Dr. Jack Cush reviews the news and journal reports from this past week from RheumNow.com.

1. Study of at-risk & early RA Synovium suggests an early pathogenic myeloid signature CD40-expressing CD206⁺CD163⁺ macrophage population before disease onset. These display heightened CD40 expression, capable of shaping stromal cell responses https://buff.ly/3UIbx9c\\\
2. Memory B cells are dysfunctional in #SLE. They are anergic B cell receptor signalling, but responsiveness to Toll-like receptor (TLR) and type I interferon signalling. BCR hyporesponsiveness of memory B cells may explain failure non-depleting B cell Rx in SLE… https://t.co/YFWmIe4kGK
3. Taiwan claims data study of 135 230 patients who received antineoplastic medications, found that immune checkpoint inhibitors use was associated with a 2-fold increased risk of developing psoriasis (HR 2.43). https://buff.ly/4hI1JGr
4. Susac syndrome is a rare disease of young women characterised by microvessel occlusive Dz limited to the brain, retina, and inner ear. Rx is steroids, but Lancet Rheumatol Review of Rx shows no benefit of immunosuppressive Rx https://t.co/FvJa9OZLWLz
5. EULAR Review of Lifestyle Improvements for Rheumatic Patients A EULAR taskforce evaluated lifestyle behaviors' effects on rheumatic and musculoskeletal diseases (RMDs), finding moderate evidence for minor benefits from certain dietary components. However, high-level evidence on… https://t.co/maaz8W5IUT
6. Full read JAMA ILD Review article. ILD= 33% idiopathic (IPF) + 15% hypersensitivity pneumonitis + 25% from CTD. 30% of ILD has cough Chest CT 91% sensitive, 71% specific 5% decr in FVC/12 mos assoc w/ 2-fold incr in mortality Rx options nintedanib or pirfenidone, TCZ, MMF, RTX… https://t.co/mxyg6PUOXw
7. Survey of UK Rheumatology pts (n 876 found 55% take daily supplements costing £10 to £200 per month (most common: vit D, C, B complex, MVI Omega 3/6). 82% take Prescription, OTC, or non-prescription pain meds, 13% sleep aids. Half of NSAID pts also take OTC supplements… https://t.co/VpMG9SiE1E
8. 211 SSc patients, men and younger women, have lower BMD than the population (Osteopenia in 52% & 16.5% osteoporosis; P=0.001). Low BMD in women assoc w/ Finger ulcers, diffuse involvement, older age, & being post-menopausal https://t.co/E743uu0NgX
9. Nationwide Readmissions Database (NRD) study of 133,187 #RA pts found that 48% were "frail". Hospital readmissions were significantly higher in the RA frail pts (57% vs 31%), & hospitalized, frail patients also had significantly higher mortality (3.36% vs 0.39%) & longer LOS… https://t.co/6lF4wrC87B
10. ACIP now recommends a pneumococcal conjugate vaccine (PCV) for all PCV-naive adults >50 yrs. Single dose of PCV (PCV15, PCV20, or PCV21) in adults >50 yrs. Pt 19-64 yrs w/ underlying conditions (prev. recommended) could recv the newly approved PCV21. https://t.co/es4KUuiYqy
11. In an RCT of colchicine vs PBO in #gout for 6 months shows that colchicine prophylaxis when initiating ULT did not increase the odds of achieving gout remission. https://t.co/kgNzw0UUIq
12. Cross-sectional study of 176 CASPAR+ PsA patients correlated Dz activity (cDAPSA) w/ SAA, IL-8, IP10 (IFNg/CXCL10), M-CSF, SCGF-β, SDF-1α) (AUC 0.802- 0.835). The panel was significantly better than CRP (AUC = 0.727, p = 0.022). https://t.co/AZq81S6NH0
13. Over a 16 yr span & 988 LBP referrals - 366 (37%) Dx w/ axSpA, w/ increase in # women w/ axSpA. Mean time to Dx decreased 9.8 yrs (2008) to 1 yr (2023). Greatest delay was LBP onset to GP eval. (3.2 yrs). Referral time improved by organizational change https://t.co/bEmaspJWG4
14. 3 yrs study Serial MRI study of SI & lumbar (LS) joints in 24 early axSpA (Sxs < 5.5yrs) over 3 yrs, showed: - SIJ developed bone marrow edema, sclerosis & erosion. - LS: fat lesions decreased & erosions increased. - Facet joint inflammation (in t0) significantly influenced yr 3. LS bony… https://t.co/czBPVXYHYa
15. An 11 yr study of 2187 #RA pts Rx w/ 3068 treatment courses of biologics or JAki, found 275 new cases of #CKD . Compared w/ CTLA4-Ig, TNFi significantly lower CKD rates (HR 0.67), whiile JAKi higher CKD rates (HR 2.16). https://t.co/2Y5BuDzJRs&nbsp;
16. Virtual Yoga Effective in Chronic Low Back Pain 
17. COVID-19 and Long-Term Risk of Autoimmune and Autoinflammatory Disorders
18. Rheumnow Live in Dallas on Feb 8,9 2025

“Nothing is going to change, unless someone does something soon.”   -Dr. Seuss