B Cell Depleters (2.21.2025)

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.

  1. NRMP Publishes 2025 Match Results. Rheumatology Stats: - Ped Rheum #5 in # U.S. DO grads (30%) - Adult Rheum #5 in Intl Med school grads (34%) - Adult: 3/132 progr. went unfilled (Ped: 20/36 unfilled) https://t.co/AsfOZMydMK
  2. TULIP Extension trial shows #SLE Rx w/ anifrolumab + SOC had less organ damage after 208wks. 354 on ANIF (+SOC) vs 561 on SOC alone = ANIF was 59.9% lower SDI (SLE damage index) (HR 0.40) vs those on SOC alone at wk 208. https://buff.ly/4kaiVWk
  3. Lupus flares after ESRD? Metanalysis of 34 studies (29 on HD/PD; 5 post transplant/KT) - extra-renal flares seen in 36% of ESRD pts & were significantly higher w/ PD/HD vs KT (OR: 4.36; 1.66-11.47, p=0.0028). Recurrence of LN after KT was 3.4% https://t.co/tXlyxsfvXd
  4. Three B-cell targeting anti-CD20 mAbs in clinical use: - Rituximab (1997) for RA, GPA, CLL, NHL, Pemphigus Vulgaris - Ofatumumab (2020) for relapsing MS - Obinutuzumab (2013) for Follicular lymphoma & CLL OFA & OBIN may be better than RTX in membranous GN pts w/ anti-RTX Abs https://buff.ly/434Qh2L
  5. Korean insurance claims data shows #RA pts have a higher risk of renal cancer (vs gen. population), unrelated to serostatus. The renal CA risk (aHR 1.34;1.04–1.78) was higher in women (aHR 1.57); but RA was not assoc w/ risk of CA of bladder, prostate or testes… https://t.co/owSeqibcPu
  6. Australian population study of 14,041 RA pts (68% F; age 65 yrs) vs 33,785 controls, preexisting cancer (CA) in RA was less prevalent (7.6% vs 14.2%). Cancer incid. rates lower in RA (CIR 19.68 vs 24.77) & stable over 3 decades. RA CIR higher for lung (CIR 1.17) & heme CA (CIR 1.21), but lower for most other CA https://buff.ly/4k5SX6a
  7. JAMA Review on Dx & Rx of Monoclonal Gammopathy of Undetermined Significance. MGUS has NO Sxs or organ damage. MGUS & Dz associations (OP, Autoimmune) were likely overestimated; M protein testing should be done if malignancy or MGCS is suspected. Risk of progression to malignancy… https://t.co/Jikc5q3BJL
  8. 8 fold risk of incident ILD in #RA pts. Data from Korean National Health Insurance, 52,325 RA pts & 261,625 controls & 4.4 yrs F/U - ILD in 3.7% of RA vs 0.5% controls (adjHR 7.84); higher in seropositive RA (aHR= 9) vs seronegative RA (aHR=4.8) https://t.co/iIoZOwFYEN
  9. Japanese study of 781 RA pts (78 dx w/ ILD; most UIP pattern). Mortality higher in RA-ILD (SMR 2.09) vs RA (1.16) vs gen population. Mortality increased w/ ILD (adj HR 2.97), advanced age (1.08/per yr) , and low BMI (3.07) https://t.co/EYKfHotZPr
  10. Prevalence of Systemic sclerosis–associated interstitial lung disease (SSc-ILD) was 49.8% - Chinese study of 223 SSc (F/U 8.1 yrs). Among SSc-ILD, 64% had progressive disease w/ elevated CRP at Dx as predictor. Overall mortality rate = 24.2% (pneumonia) w/ predictors of age smoking & CRP https://t.co/Lb98KziPOj
  11. Survey on Corticosteroid (CS) use in PFAPA syndrome included 144 MDs (67% pedi-Rheums); 92% use CS in PFAPA flares. 42% expected a response w/in 12 hrs. 31% use CS ‘routinely. Med literature cites Prednisone as most preferred CS (48%). Response to CS ~ 95% https://t.co/V1wkhNaNAP 
  12. Targeting PD-1 in Rheumatoid Arthritis  
  13. Growing Physician Enthusiasm for AI in Healthcare 
  14. Obinutuzumab Efficacy in Active Lupus Nephritis  

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Disclosures
The author has no conflicts of interest to disclose related to this subject
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