RheumNow Podcast - Despite Corona (3.6.20)

Jack Cush, MD

Mar 06, 2020 3:00 am

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.

Risk factors for severe cranial ischaemic complications (sCIC) in GCA studied in 295 pts - 61 developed sCIC. Vision complications increased with age & jaw claudication (OR 3.43); decreased with PMR Sxs & higher CRP. Afib independent predictor of stroke. https://t.co/8VoZoVGVIp
ANA positivity very common with liver diseases - 91% in syst autoimmune dz, 93% in PBC, 49% Autoimmune hepatitis, 19% in HBV, 14% in HCV, 23.5% in Hepatocellular carcinoma; but few had ANA ≥ 1:320 (5 HCC, 2.5%HBV, 1.6% HCV). Patterns also varied. https://t.co/1wnr9sHjye
NICE cost analysis of combination DMARDs vs Biologic/MTX in 205 RA pts shows combo DMARDS achieve similar clinical benefits more cheaply than high-cost biologics https://t.co/vEjQFPNHYx
Study of 199 pts shows increased prevalence of obstructive sleep apnea (OSA) in rheumatoid arthritis pts (based on polysomnography) with moderate-to-severe OSA (AHI ≥ 15) in 23% https://t.co/tGGa8dGyrG
35,248 rheumatic patients with 16 years follow-up finds an increase in all cause mortality in fibromyalgia & widespread pain (RR 1.19-1.38), and also for RA (RR 1.52). FM deaths included accidents, diabetes, suicide and HTN disorders https://t.co/VP0DkvSJoY
Johnston County OA Project (1999–2015) found 327/800 with Xray hand OA (rHOA) - they were older, more often white and female. Women were more likely than men to have incident HOA, particularly for DIP rOA. HOA more frequent in whites vs AA https://t.co/wdXlrNqsIG
EPOSA - 5 european OA cohorts studied showing 27% had 1 or falls; 10% fell twice or more (recurrent faller). Risk was associated with knee OA (RR-1.55). Opioids and analgesics mediated the associations between clinical OA and (recurrent) falls. https://t.co/9g87cZSvRK
Serum aldolase serves as a useful marker for diagnosis and assessment of disease activity in patients with adult-onset Still's disease. https://t.co/K1Z8uqLwML
Vitamin D deficiency is associated with lumbar disc disease and LBP in postmenopausal women; moresoe w/ very low vitamin D concentration < 10 ng/mL - study of 232 postmenopausal women https://t.co/Kmu8nMOaf7
U.S. FDA Accepts Regulatory Submission for Tanezumab, an NGF inhibitor, for Treatment for Patients with Chronic Pain Due to Moderate-to-Severe Osteoarthritis https://t.co/9NsESTnn4S
Venom Peptide-Steroid Conjugate Effective in Collagen Induced Arthritis
Airway Inflammation Drives Rheumatoid Risk