RheumNow Podcast – Modern Treatment of RA Pregnancy (6.25.2021) Save

Dr. Jack Cush reviews this week’s news and journal reports featured on RheumNow.com.

1. The FDA has informed Abbvie that their supplemental application for new indications (PsA and AS) for upadacitinib (Rinvoq) has been delayed; the FDA citing its ongoing review of tofacitinibs safety concerns stemming from the ORAL Surveillance RA study https://bit.ly/3zXB1DN
2. FDA has granted emergency use authorization (EUA) for Actemra (tocilizumab) us in treating hospitalized COVID-19 (adults and kids) patients on steroids and who require, supplemental oxygen, mechanical ventilation, or ECMO https://bit.ly/3xVqWFq
3. Tofacitinib Efficacy in COVID-19 Pneumonia
4. Danish population study shows that all cause mortality in GCA is increased 49%,(RR 1.49; CI1.36-1.64) after 1 year but less so at 10 years (RR 1.03: 1.00-1.05). Deaths usually due to infectious, endocrine, cardiovascular, GI diseases https://t.co/p36zDskf6y
5. The Swedish Rheumatology Quality Register looked at risk of ant. uveitis (AU). From 4851 starting secukinumab (456) or TNFinhibitor (4395), there was higher AU risk w/ SEC (adj HR 2.32; 1.16-4.63) & ETN (1.82;1.13-2.93) (ADA as referent) https://t.co/j06MtKedYU
6. Metanalysis shows no clear association between allopurinol use and a lowered all-cause mortality in gout patients, but the number of studies was small https://t.co/MM0nIjZPbV
7. Italian survey foud 82% of MSK healthcare workers willing to receive COVID-19 vaccine, but only 55% of their rheumatic Dz patients were as willing, even if they perceived they were at risk. Not out of fear or distrust. more education needed https://t.co/nPhhME2dnC
8. French Vasculitis registry studied 354 GPA patients- 25% had hypereosinophilia (HE) ≥ 500; mostly male (73%) w/ most skin dz (49%) peripheral neuropathy (32%) & higher BVAS (21 vs 18, p= 0.01): severe HE had more baseline renal dysfunction https://t.co/G4s3CEavL9
9. Mouse model of psoriasis; 10 week exposure of western diet (high sugar & fat) induced dysbiosis and increased skin psoriasis & PsA , with increased IL-17A γδ T cells and helper type 17 cytokines. Treatment w/ Abx reduced IL-23 mediated dz. https://t.co/fTCnYiQ3wL
10. Progression from Psoriasis to Psoriatic Arthritis
11. Better Outcomes with Modern T2T in Pregnancy